Inhalation efficacy of RFI-641 in an African green monkey model of RSV infection

Journal of Medical Primatology

Volumn 32, Issue 2, 2003, Pages 82-88

  Weiss, W J ^a   Murphy, T ^a   Lynch, M E ^b   Frye, J ^b   Buklan, A ^a   Gray, B ^a   Lenoy, E ^a   Mitelman, S ^a   O'Connell, J ^a   Quartuccio, S ^a   Huntley, C ^a  

^a WYETH RESEARCH   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

Primate efficacy; Respiratory syncytial; Viral pneumonia

Indexed keywords

4,4' BIS 4,6 BIS[3 (BISCARBAMOYLMETHYLSULFAMOYL)PHENYLAMINO][1,3,5]TRIAZIN 2 YLAMINOBIPHENYL 2,2' DISULFONIC ACID; ANTIVIRUS AGENT; RFI 641; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CERCOPITHECIDAE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG EXPOSURE; DRUG POTENCY; DRUG STRUCTURE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LONG TERM EXPOSURE; LUNG LAVAGE; MALE; NEBULIZER; NONHUMAN; NOSE; PRIMATE; PRIORITY JOURNAL; PROPHYLAXIS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT INFECTION; SAMPLING; STATISTICAL SIGNIFICANCE; THROAT CULTURE; VIRUS INFECTION; VIRUS INHIBITION; VIRUS LOAD;

ANIMALIA; CERCOPITHECIDAE; CERCOPITHECUS AETHIOPS; HUMAN RESPIRATORY SYNCYTIAL VIRUS; PRIMATES; RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS; SYNCYTIAL VIRUS;

EID: 0038147423     PISSN: 00472565     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0684.2003.00014.x     Document Type: Article

References (22)

1. AULABAUGH A, DING W, ELLESTAD G, GAZUMYAN A, HESS C, KRISHNAMURTHY G, MITSNER B, ZACARDI J: Inhibition of respiratory syncytial virus by a new class of chemotherapeutic agents. Drugs of the Future 25:287-294, 2000.
2. DING W, MITSNER, B, KRISHNAMURTHY G, AULABAUGH A, HESS C, ZACCARDI J, CUTLER M, FELD B, GAZUMYAN A, RAIFELD Y, NIKITENKO A, LANG S, GLUZMAN Y, O'HARA B, ELLESTAD G: Novel and specific respiratory syncytial virus inhibitors that target virus fusion. J Med Chem 41:2671-2675, 1998.
3. DOWELL S, ANDERSON L, GRAY H, ERDMAN D, PLOUFFE J, FILE T, MARSTON B, BREIMAN R: Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. J Infect Disease 174:456-462, 1996.
4. FALSEY A, WALSH E: Respiratory syncytial virus infection in adults. Clin Microbiol Reviews 13:371-384, 2000.
5. HALL C: Respiratory syncytial virus: a continuing culprit and conundrum. J Pediatr 135:S2-S7, 1999.
6. HUNTLEY C: Abstr 40th Intersci Conf Antimicrob Agents Chemother, abstr. 187, p. 262, 2000
7. KIMPEN J: Experimental models for respiratory syncytial virus infections. Rev Med Microbiol 7:115-122, 1996.
8. KNIGHT V, GILBERT B: Aerosol treatment of respiratory viral disease. Lung Suppl 168:406-413, 1990.
9. KOFF W, CAPLAN F, CASE S, HALSTEAD B: Cell-mediated immune response to respiratory syncytial virus infection in owl monkeys. Clin Exp Immunol 53:272-280, 1983.
10. LA VIA W, MARKS M, STUTMAN H: Respiratory syncytial virus puzzle: clinical features, pathophysiology, treatment and prevention. J Pediatr 121:503-510, 1992.
11. LA VIA W, GRANT S, STUTMAN H, MARKS M: Clinical profile of pediatric patients hospitalized with respiratory syncytial virus infection. Clin Pediatr 450-454, 1993.
12. MCINTOSH K: Respiratory syncytial virus. In: Viral Infections of Humans, 4th edn. EVANS & KASLOW (eds). New York: Plenum Medical Book Co. 691-705, 1997.
13. O'RIORDAN T, FARIS M: Inhaled antimicrobial therapy. Respir Care Clin N Am 5:4:617-631, 1999.
14. PRINCE G, JENSON B, HORSWOOD R, CAMAPGO E, CHANOCK R: The pathogenesis of respiratory syncytial virus infection in cotton rats. Am J Pathol 93:771-783, 1978.
15. SHEERAN P, JAFRI H, CARUBELLI C, SAAVEDRA J, JOHNSON C, KISHER K, SANCHEZ P, RAMILLO O: Elevated cytokine concentrations in the nasopharyngeal and tracheal secretions of children with respiratory syncytial virus disease. Pediatr Infect Dis J 18:115-122, 1999.
16. SHIGETA, S: Recent progress in antiviral chemotherapy for respiratory syncytial virus infections. Exp Opin Invest Drugs 9:221-235, 2000.
17. SUDO K, WANTANABE W, MORI S, KONNO K, SHIGETA S, YOKOTA T: Mouse model of respiratory syncytial virus infection to evaluate antiviral activity in vivo. Antiviral Chem Chemother 10:135-139, 1999.
18. WEISS W: Abstr 40th Intersci Conf Antimicrob Agents Chemother, abstr. 186, p. 261, 2000.
19. WONG D, ROSENBAND, M, HOVEY K, OGRA P: Respiratory syncytial virus infection in immunosuppressed animals. J Med Virol 17:359-370, 1985.
20. WYDE P: Respiratory syncytial virus (RSV) disease and prospects for its control. Antiviral Res 39:63-79, 1998.
21. WYDE P, MOORE-POVEDA D, O'HARA B, DING W, MITSNER B, GILBERT B: CL387626 exhibits marked and unusual antiviral activity against respiratory syncytial virus in tissue culture and in cotton rats. Antiviral Res 38:31-42, 1998.
22. ZOLNAI A, TOTH E, WILSON R, FRENYO V: Comparison of 3-H-thymidine incorporation and Celltiter 96 aqueous colorimetric assays in cell proliferation of bovine mono-nuclear cells. Acta Vet Hung 46:191-197, 1988.