Urinary profile of androgen metabolites in a population of sportswomen during the menstrual cycle

International Journal of Sports Medicine

Volumn 24, Issue 3, 2003, Pages 197-202

  Bricout, V A ^a   Wright, F ^b   Lagoguey, M ^b  

^a UNIVERSITY OF AVIGNON   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

Epitestosterone glucuronide; Exercise; Female; Testosterone glucuronide

Indexed keywords

ANDROGEN; ANDROSTANEDIOL; ANDROSTANOLONE; CREATININE; EPITESTOSTERONE; EPITESTOSTERONE GLUCURONIDE; ESTRADIOL; HYDROCORTISONE; PROGESTERONE; TESTOSTERONE; TESTOSTERONE GLUCURONIDE; UNCLASSIFIED DRUG;

ADULT; ANDROGEN METABOLISM; ARTICLE; ATHLETE; CONTROLLED STUDY; EXERCISE; FEMALE; FOLLICULAR PHASE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE URINE LEVEL; LIFESTYLE; LUTEAL PHASE; MENSTRUAL CYCLE; METABOLITE; NORMAL HUMAN; PHYSICAL ACTIVITY; RADIOIMMUNOASSAY; STATISTICAL SIGNIFICANCE; STEROID URINE LEVEL; TRAINING; URINALYSIS;

ADULT; ANDROGENS; ANDROSTANE-3,17-DIOL; CREATININE; ESTRADIOL; EXERCISE; FEMALE; HUMANS; LIFE STYLE; MENSTRUAL CYCLE; PROGESTERONE; SPORTS; TESTOSTERONE;

EID: 0038146885     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-39090     Document Type: Article

References (34)

1. Abraham GE, Maroulis GB, Marshall JB. Evaluation of ovulation and corpus luteum functioning using measurements of plasma progesterone. Obstet Gynecol 1974; 44: 522-525
2. Aguilera R, Becchi M, Casabianca H, Hatton CK, Catlin DH, Starcevic B, Pope H. Improved method of detection of testosterone abuse by gas chromatography/combustion/isotope ratio mass spectrometry analysis of urinary steroids. J Mass Spectrum 1996; 31: 169-176
3. Bowers L, Bowers S. Direct measurement of steroid sulfate and glucuronide conjugates with high-performance liquid chromatography-mass spectrometry. J Chromatogr 1996; B 687: 61-68
4. Combie J, Blake JW, Nugent TE, Tobin T. Morphine glucuronide hydrolysis: superiority of beta-glucuronidase from patella vulgata. Clin Chem 1982; 28: 83-86
5. Dehennin L, Jondet M, Scholler R. Androgen and 19-norsteroids profiles in human preovulatory follicles from stimulated cycles: an isotope dilution-mass spectrometric study. J Steroid Biochem 1987; 26: 399-405
6. Dehennin L. Secretion by the human testis of epitestosterone with its sulfoconjugate and precursor androgen 5-androstene 3β,17α-diol. J Steroid Biochem Molec Biol 1993; 44: 171-177
7. Dehennin L, Delgado A, Peres G. Urinary profile of androgen metabolites at different stage of pubertal development in a population of sporting male subjects. Eur J Endoc 1994; 130: 53-59
8. Dennerstein L, Browne JB, Gotts G, Morse CA, Farley TMM, Pinol A. Menstrual cycle hormonal profiles of women with and without premenstrual syndrome. J Psych Obst Gynecol 1993; 14: 259-268
9. Donike M, Bärwald KR, Klosterman K, Schänzer W, Zimmermann J. Nachweis von exogenem testosterone. Heck H, Holmann H, Liesen H, Rost R (Eds). In: Sport leistung und Gesundheit. Deutsche Ärzte-Verlag, Köln: 1983: 293-300
10. Donike M, Zimmermann J. Detection of exogenous testosterone by GC/MS in routine dope analysis. Summaries of papers of 2nd symposium on the analysis of steroids. Szeged, Hungary; 1984: C10-C11
11. Dorfman RI, Shipley RA. In: Androgens. Wiley J & sons. New York; 1956: 124-156
12. Dorfman RI, de Nicolas A, Gottfried H, Forchielli E. Testosterone and epitestosterone in human urine. In: Tamm J (Ed). Testosterone. Georg Thieme Verlag, Stuttgart: 1968: 216-219
13. Dray F, Ledru MJ. Métabolisme de l'épitestostérone. C R Acad Sci Paris 1966; Série C262: 679-681
14. Guezennec CY, Lafargue JP, Bricout VA, Merino D, Serrurier BD. Effect of competition stress on tests used assess testosterone administration in athletes. Int J Sports Med 1995; 16: 368-372
15. Graef V, Furuya E, Nishikaze O. Hydrolysis of steroid glucuronides with beta-glucuronidase preparations from bovine liver, Helix promatia, and E. Coli. Clin Chem 1977; 23: 532-535
16. Hakim RB, Gray RH, Zacur HA. Is there a need for creatinine adjustment of urinary steroid hormone levels in studies of early fetal loss? Clin Chem Acta 1994; 230: 209-214
17. Häkkinen K, Pakarinen A. Acute hormonal responses to heavy resistance exercise in men and women at different ages. Int J Sports Med 1995; 16: 507-513
18. Hall Moran V, Leathard HL, Coley J. Urinary hormone levels during the natural menstrual cycle: the effects of age. J Endoc 2001; 170: 157-164
19. Huff RW, Pauerstein CJ. Human reproduction. In: Physiology and pathophysiology. Wiley J & sons. New-York; 1979: 235-256
20. Kawasaki T, Itoh K, Uezono K, Sasaki H. A simple method for estimating 24 h urinary sodium and potassium excretion from second morning voiding urine specimen in adults. Clin Exp Pharmacol Physiol 1993; 20: 7-14
21. Kicmann AT, Brooks RV, Collyer SC, Cowan DA, Nanjee MN, Southan GJ, Wheeler MJ. Criteria to indicate testosterone administration. Br J Sp Med 1990; 24: 253-264
22. Kicmann AT, Coutts SB, Cowan DA, Handelsman DJ, Howe CJ, Burring S, Wu FCW. Adrenal and gonadal contributions to urinary excretion and plasma concentration of epitestosterone in men - effect of adrenal stimulation and implications for detection of testosterone abuse. Clin Endoc 1999; 50: 661-668
23. Kuttenn F, Rigaud C, Wright F. Treatment of hirsutism by oral cyproterone acetate and percutaneous estradiol. J Clin Endocrinol Metab 1980; 51: 1107-1111
24. Lagoguey M, Dray F, Chauffournier JM, Reinberg A. Circadian and circannual rhythms of urinary testosterone and epitestosterone glucuronides in healthy adult men. Int J Chronobiol 1973; 1: 91-93
25. Longhino N, Tajic M, Vedris M, Jankovic D, Drobnjac P. Urinary excretion of androstenedione, testosterone, epitestosterone, dehydroepian-drosterone during the normal menstrual cycle. Acta Endoc 1968; 59: 644-651
26. Mandelbaum J. Exploration de l'axe hypothalamo-hypophyso-ovarien. In: Mauvais-Jarvis P, Médecine de la reproduction. Flammarion Médecine Science Editions. Paris; 1986: 219-244
27. Nuck BA, Lucky AW. Epitestosterone: a potential new antiandrogen. J Invest Dermato 1987; 89: 209-211
28. Shackleton CH. Profiling steroid hormones and urinary steroids. J Chromatogr 1986; 379: 91-156
29. Starkà L, Bicikova M, Hampl R. Epitestosterone: an endogenous antiandrogen ? J Steroid Biochem 1989; 33: 1019-1021
30. Ukkola O, Gagnon J, Rankinen T, Thompson PA, Hong Y, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Age, body mass index, race, and other determinants of steroid hormone variability: the heritage family study. Eur J Endocrinol 2001; 145: 1-9
31. van de Kerkhof DH, de Boer D, Thijssen JH, Maes RA. Evaluation of testosterone/epitestosterone ratio influential factors as determined in doping analysis. J Anal Toxicol 2000; 24: 102-115
32. Wright F. Urinary 5α-androstane-3 α, 17β, diol radioimmunoassay: a new clinical evaluation. J Clin Endocrinol Metab 1978; 47: 850-854
33. Zacur H, Kaufman SC, Smith B, Westhoff C, Helbig D, Lee YJ, Gentile G. Does creatinine adjustment of urinary pregnanediol glucuronide reduce or introduce measurement errors? J Gynecol Endoc 1997; 11: 29-33
34. Zietz B, Hrach S, Schölmerich J, Straub RH. Differential age related changes in hypothalamus-pituitary-axis hormones in heathly women and men. Role of interleukin 6. Exp Clin Endocrinol Diabetes 2001; 109: 93-101