Disposition and functions of clarithromycin in human THP-1 monocytes during stimulated and unstimulated conditions

Research Communications in Molecular Pathology and Pharmacology

Volumn 110, Issue 3-4, 2001, Pages 183-208

  Ives, Timothy J ^a   Schwab, Ute E ^b   Ward, E Stacy ^c   Butts, John D ^a,b   Hall, Iris H ^c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF NORTH CAROLINA HOSPITALS   (United States)

Author keywords

Clarithromycin; Macrolide antibiotics; Monocytes; Phagocytosis; Protein kinase C; THP 1

Indexed keywords

CATHEPSIN D; CLARITHROMYCIN; ENZYME PRECURSOR; HYDROGEN PEROXIDE; INTERLEUKIN 1; ION CHANNEL; MACROLIDE; NITRIC OXIDE; PROTEIN KINASE C; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG DISPOSITION; DRUG MECHANISM; DRUG TRANSPORT; ENERGY; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; INFLAMMATION; LIPID PEROXIDATION; LYSOSOME; MACROPHAGE; MEDIATOR RELEASE; MONOCYTE; NEUTROPHIL; PH; PHAGOCYTE; PHAGOSOME; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE;

CLARITHROMYCIN; ENZYME PRECURSORS; HUMANS; MONOCYTES; PHAGOCYTOSIS; PROTEIN KINASE C; STAPHYLOCOCCUS AUREUS; TUMOR CELLS, CULTURED;

EID: 0038137622     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Allen L-A. H., Aderem A. (1996) Mechanism of phagocytosis. Curr Opin Immunol. 8, 36-40.
2. Anderson R., Joonme G., Van Rensburg C.E.J. (1988) An in vitro evaluation of the cellular uptake and intraphagocytic bioactivity of clarithromycin (A-56268, TE-031), a new macrolide antimicrobial agent. J. Antimicrob. Chemother 22, 923-933.
3. Anderson R., Theron A.J., Feldman C. (1996) Membrane-stabilizing, anti-inflammatory interactions of macrolides with human neutrophils. Inflammation 20, 693-705.
4. Babior B. M. (2000) Phagocytes and oxidative stress. Amer J Med. 109, 33-44.
5. 2-dependent bactericidal mechanisms. Chemotherapy 45, 268-276.
6. Clements M. O., Foster S.J. (1999) Stress resistance in Staphylococcus aureus. Trends Microbiol. 7, 458-462.
7. Delic J. J., Coppey H., Magdelenat M., Coppey-Moisan M. (1991) Impossibilities of acridine orange intercalation in nuclear DNA of living cells. Expt. Cell Res. 194, 147-153.
8. Fernandes P. B., Hardy D.J., McDaniel D., Hanson C.W., Swanson R.N. (1989) In vitro and in vivo activities of clarithromycin against Mycobacterium avium. Antimicrob. Agents Chemother. 33, 1531-1534.
9. Fietta A., Mrtlini C., Gialdroni Grassi G. (1997) Inhibition of intracellular growth of Staphylococcus aureus by exposure of infected human monocytes to clarithromycin and azithromycin. J Chemotherapy 9, 17-22.
10. 4, polymorphonuclear leukocytes and inflammatory exudates in the rat. Prostaglandins 28, 13-27.
11. nd ed. Apotekarsocieteten, Stockholm, Sweden.
12. Gladue R. P., Bright G.M., Isaacon R.E., Newborg M.F. (1989) In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob Agent Chemother. 33:277-82.
13. Golder M., Farkas-Himsley H., Kormendy A. (1983) Bacterial phagocytosis monitored by fluoresence and extracellular quenching: ingestion and intracellular killing. Lab. Medicine 14, 291-294.
14. Gorzynski E. A., Gutman S.I., Allen W. (1989) Comparative antimycobacterial activities of difloxacin, temafloxacin, enoxacin, pefloxacin, reference fluroquinolones and a new macrolide clarithromycin. Antimicrob. Agents Chemother. 33, 591-592.
15. Hall I. H., Wong O.T., Simlot S., Miller M.C. III, Izydore R.A. (1992) Antineoplastic activities and cytotoxicity of 1-acyl and 1,2-diacyl-1,2,4-triazolidine-3,5-diones in murine and human tissue culture cells. Anti Cancer Res. 12, 1355-1362.
16. Hand, W. L., King-Thompson N.L. (1989) The entry of antibiotics into human monocytes. J Antimicrob Ther. 23, 681-689.
17. Heifets, L. B., Lindholm-Levy P.J., Comstock R.D. (1992) Clarithromycin minimal inhibitory and bactericidal concentration. Antimicrob. Agents Chemother. 145, 856-8.
18. Ishiguro, M., Koga H., Kohon S., Hayashi T., Yamaguchi K., Hirota M. (1989) Penetration of macrolides into human polymorphonuclear leukocytes. J Antimicrob Chemother. 24, 719-729.
19. Kadir, T., F. V. Izzetin, Cevikbas A., Johansson C.B., Clark P. (2000) In vitro effects of clarithromycin on human polymorphonuclear leukocytes functions. Chemother. 46:198-302.
20. Klempner, M. S., Styrt B. (1981) Clindamycin uptake in human neutrophils. J Infect Dis. 144, 472-479.
21. Levert, H., Gressier B., Moutard I., Brunet C., Dinie T., Luyckx M., Cazin M., Cazin J.C. (1998) Azithromycin impact on neutrophil oxidative metabolism depends on exposure time. Inflammation 22, 91-201.
22. Mills, S. D., Finlay B.B. (1998) Isolation and characterization of Salmonella typhimurium and Yersinia pseudotuberculosis containing phagosomes from infected mouse macrophages; Y. pseudotuberculosis traffics to terminal lysosomes where they are degenerated. Eur J Cell Biol. 77, 35-47.
23. Mor, N., Heifets L. (1993) MICs and MBCs of clarithromycin against Mycobacterium avium with human macrophages. Antimicrob. Agents Chemother. 37, 111-4.
24. Patel, K. B., Xuan D., Tessier P.R., Russamanno J.H., Quintiliani R., Nightingale C. H. (1996). Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. Antimicrob. Agents Chemother. 40, 2375-9.
25. Perronne C., Gikas A., Truffot-Pernot C., Grosset J., Pocidalo J., Vilde J.L. (1990) Activities of clarithromycin, sulfisoxazole, and rifabutin against Mycobacterium avium complex within human macrophages. Antimicrob. Agents Chemother. 34, 1356-1359.
26. Rodvold K.A., Gotfried M.H., Danziger L.H., Servi R.J. (1997) Intrapulmonary steady-state concentrations of clarithromycin and azithromycin in normal healthy adult volunteers. Antimicrob. Agents Chemother. 41, 1399-1402.
27. Russell D.G. (1995) Of microbes and macrophages: entry, survival, and persistence. Curr Opin Immunol. 7, 479-484.
28. Steinberg T.H., Hand W.L. (1984) Effects of phagocytosis on antibiotic and nucleoside uptake in human polymorphonuclear leukocytes. J Infect Dis. 149, 397-403.
29. Scaglione F., Dugnani D.G, Fraschini F. (1993) A new model examining intracellular and extracellular activity of amoxicillin, azithromycin and clarithromycin in infected cells. Chemotherapy 39, 416-423.
30. Styrt B., Klempner M.S. (1986) Inhibition of neutrophil oxidation metabolism by lysosomotropic weak bases. Blood. 67, 334-342.
31. Truffot-Pernot C., Ji B., Grosset J. (1991) Effect of pH on the in vitro potency of clarithromycin against Mycobacterium avium complex. Antimicrob. Agents Chemother. 35,:1677-1678.
32. Yajko D. M., Nassos P.T., Sanders C.A., Gonzalez P.C., Hadley W.K. (1992) Comparison of the intracellular activities of clarithromycin and erythromycin against Mycobacterium avium complex strains in J774 cells and in alveolar macrophages from human immunodeficiency virus type-1 infected individuals. Antimicrob. Agents Chemother. 36, 1163-5.