Testing and modelling the interaction of alfentanil and propofol on the EEG

European Journal of Anaesthesiology

Volumn 20, Issue 5, 2003, Pages 363-372

  Schwilden, Helmut ^a   Fechner, J ^a   Albrecht, S ^a   Hering, W ^a   Ihmsen, H ^a   Schuttler J ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Anaesthesia, intravenous; Anaesthetics, intravenous, propofol; Chemical and pharmacological phenomena, drug interactions, drug synergism; Narcotics, alfentanil

Indexed keywords

ALFENTANIL; ANESTHETIC AGENT; HYPNOTIC SEDATIVE AGENT; INTRAVENOUS ANESTHETIC AGENT; MIDAZOLAM; PROPOFOL;

ABDOMEN; ABDOMINAL SURGERY; ADULT; ANESTHESIA INDUCTION; ARTERIAL BLOOD; ARTICLE; ARTIFICIAL VENTILATION; BIOLOGICAL MODEL; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONSCIOUSNESS; CONSCIOUSNESS DISORDER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG POTENTIATION; ELECTROENCEPHALOGRAM; ELECTROENCEPHALOGRAPHY; EYELID CLOSURE; FEEDBACK SYSTEM; FEMALE; HUMAN; INTRAVENOUS ANESTHESIA; MALE; PREMEDICATION; RANDOMIZED CONTROLLED TRIAL;

ABDOMEN; ADULT; ALFENTANIL; ANESTHETICS, COMBINED; ANESTHETICS, INTRAVENOUS; CONSCIOUSNESS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PROPOFOL;

EID: 0038137599     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0265021503000553     Document Type: Article

References (22)

1. Iselin-Chaves IA, Flaishon R, Sebel PS, et al. The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index. Anesth Analg 1998; 87: 949-955.
2. Kazama T, Ikeda K, Morita K, Katoh T, Kikura M. Propofol concentration required for endotracheal intubation with a laryngoscope or fiberscope and its interaction with fentanyl. Anesth Analg 1998; 86: 872-879.
3. Smith C, McEwan AI, Jhaveri R, et al. The interaction of fentanyl on the Cp50 of propofol for loss of consciousness and skin incision. Anesthesiology 1994; 81: 820-828.
4. Vuyk J, Lim T, Engbers FH, Burm AG, Vletter AA, Bovill JG. The pharmacodynamic interaction of propofol and alfentanil during lower abdominal surgery in women. Anesthesiology 1995; 83: 8-22.
5. Vuyk J, Engbers FH, Burm AGL, et al. Pharmacodynamic interaction between propofol and alfentanil when given for induction of anesthesia. Anesthesiology 1996; 84: 288-299.
6. Vuyk J. Pharmacokinetic and pharmacodynamic interactions between opioids and propofol. J Clin Anesth 1997; 9: 23S-26S.
7. Vuyk J, Mertens MJ, Olofsen E, Burm AG, Bovill JG. Propofol anesthesia and rational opioid selection: determination of optimal EC50-EC95 propofol-opioid concentrations that assure adequate anesthesia and a rapid return of consciousness. Anesthesiology 1997; 87: 1549-1562.
8. Maitre PO, Vozeh S, Heykants J, Thomson DA, Stanski DR. Population pharmacokinetics of alfentanil: the average dose-plasma concentration relationship and interindividual variability in patients. Anesthesiology 1987; 66: 3-12.
9. Schwilden H, Schuttler J, Stoeckel H. Closed-loop feedback control of methohexital anesthesia by quantitative EEG analysis in humans. Anesthesiology 1987; 67: 341-347.
10. Schwilden H, Stoeckel H, Schuttler J. Closed-loop feedback control of propofol anaesthesia by quantitative EEG analysis in humans. Br J Anaesth 1989; 62: 290-296.
11. Ihmsen H, Tzabazis A, Schywalski M, Schwilden H. Propofol in rats: testing for nonlinear pharmacokinetics and modelling acute tolerance to EEG effects. Eur J Anaesthesiol 2002; 19: 177-188.
12. Schraag S, Mohl U, Bothner U, Georgieff M. Interaction modeling of propofol and sufentanil on loss of consciousness. J Clin Anesth 1999; 11: 391-396.
13. Scott JC, Ponganis KV, Stanski DR. EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil. Anesthesiology 1985; 62: 234-241.
14. Eger EI. Does 1 + 1 = 2? Anesth Analg 1989; 68: 551-552.
15. Berenbaum MC. What is synergy? Pharmacol Rev 1989; 41: 93-141.
16. Ihmsen H, Albrecht S, Fechner J, Hering W, Schüttler J. The elimination of alfentanil is decreased by propofol. Anesthesiology 2000; 93: A531.
17. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993; 52: 259-285.
18. Katz J, Kavanagh BP, Sandier AN, et al. Preemptive analgesia. Clinical evidence of neuroplasticity contributing to postoperative pain. Anesthesiology 1992; 77: 439-446.
19. Celerier E, Rivat C, Jun Y, et al. Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. Anesthesiology 2000; 92: 465-472.
20. Eisenach JC. Preemptive hyperalgesia, not analgesia? Anesthesiology 2000; 92: 308-309.
21. Guignard B, Bossard AE, Coste C, et al. Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology 2000; 93: 409-417.
22. Dierkcx P. Curve and Surface Fitting with Splines. New York, USA: Oxford University Press, 1993.