Eustachian tube goblet cell density during and after acute otitis media caused by Streptococcus pneumoniae: A morphometric analysis

Otology and Neurotology

Volumn 24, Issue 3, 2003, Pages 365-370

  Cayé Thomasen, Per ^a   Tos, Mirko ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Histopathology; Infection; Middle ear; Mucus

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY TUBE; CELL DENSITY; CONTROLLED STUDY; EXPERIMENTAL INFECTION; GOBLET CELL; HISTOPATHOLOGY; MALE; MIDDLE EAR MUCOSA; MORPHOMETRICS; MUCUS GLAND; MUCUS SECRETION; NONHUMAN; OTITIS MEDIA; PRIORITY JOURNAL; RAT; STREPTOCOCCUS PNEUMONIAE;

ACUTE DISEASE; ANIMALS; CELL COUNT; EPITHELIUM; EUSTACHIAN TUBE; GOBLET CELLS; MALE; OTITIS MEDIA, SUPPURATIVE; RATS; RATS, SPRAGUE-DAWLEY; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; TIME FACTORS;

EID: 0038137071     PISSN: 15317129     EISSN: None     Source Type: Journal    
DOI: 10.1097/00129492-200305000-00003     Document Type: Article

References (47)

1. Rogers DF. Airway goblet cells: responsive and adaptable frontline defenders. Eur Respir J 1994;7:1690-6.
2. Carlsson B, Ohlsson K. Localization of antileukoprotease in middle ear mucosa. Acta Otolaryngol (Stockh) 1983;95:111-6.
3. Lim DJ, Liu YS, Birck H. Secretory lysozyme of the human middle ear mucosa: immunocytochemical localization. Ann Otol Rhinol Laryngol 1976;85:50-60.
4. Hanamure Y, Lim DJ. Normal distribution of lysozyme- and lactoferrin-secreting cells in the chinchilla tubotympanum. Am J Otolaryngol 1986;4:410-25.
5. Forseni M. Inflammatory mediators and immunocompetent cells in the middle ear with particular regards to otitis media and tympanosclerosis. Stockholm, Sweden, Department of Otorhinolaryngology, Karolinska Hospital, 2000 (dissertation).
6. Tachibana M, Morioka H, Tanimura F, et al. Experimental immune complex otitis media: localization of IgG by protein A-gold technique. Auris Nasus Larynx 1985;12(Suppl 1):S86-8.
7. Hentzer E. Histologic studies of the normal mucosa in the middle ear mastoid cavities and eustachian tube. Ann Otol Rhinol Laryngol 1970;79:825-34.
8. Lim DJ. Normal and pathologic mucosa of the middle ear and eustachian tube. Clin Otolaryngol 1979;4:213-34.
9. Tos M, Bak-Pedersen K. Goblet cell population in the normal middle ear and eustachian tube of children and adults. Ann Otol Rhinol Laryngol 1976;85(Suppl 25):44-50.
10. Tos M, Bak-Pedersen K. Goblet cell population in the pathologic middle ear and eustachian tube of children and adults. Ann Otol Rhinol Laryngol 1977;86:209-18.
11. Matsune A, Sando I, Takahashi H. Distribution of eustachian tube goblet cells and glands in children with and without otitis media. Ann Otol Rhinol Laryngol 1992;101:750-4.
12. Albiin N, Hellstrom S, Salen B, et al. The anatomy of the eustachian tube in the rat: a macro- and microscopical study. Anat Rec 1983;207;513-21.
13. Mulder JJS. Morphological and functional aspects of the Eustachian tube of the rat. Emmen, The Netherlands, Proefschrift Katholieke Universiteit Nijmegen, 1999 (dissertation).
14. Sade J, Luntz M, Berger G. The eustachian tube profile in children: a quantitative histopathologic study of the ET lumen and mucosal lining involvement in acute and secretory otitis media. Adv Otorhinolaryngol 1988;39:18-36.
15. Giebink GS, Ripley ML, Wright PF: Eustachian tube histopathology during experimental influenza A virus infection in the chinchilla. Ann Otol Rhinol Laryngol 1987;96:199-206.
16. Caye-Thomasen P. Histopathology of experimental acute otitis media caused by various bacteria: an investigation on goblet cell density, polyp- and adhesion formation, bone modeling dynamics and the effect of antibiotic treatment. APMIS Suppl 2001;104:1-35.
17. Stangerup SE, Tos M. The etiologic role of acute suppurative otitis media in chronic secretory otitis. Am J Otol 1985;6:126-31.
18. Alho OP, Oja H, Koivu M, et al. Risk factors for chronic otitis media with effusion in infancy: each acute otitis media episode induces a high but transient risk. Arch Otolaryngol Head Neck Surg 1995;121:839-43.
19. Hermansson A, Emgard P, Prellner K, et al. A rat model for pneumococcal otitis media. Am J Otolaryngol 1988;9:97-101.
20. Lim DJ, Klainer A. Cellular reactions in acute otitis media: scanning and transmission electron microscopy. Laryngoscope 1971;81:1772-86.
21. Coles SJ, Reid LR. Glycoprotein secretion in vitro by human airway: normal and chronic bronchitis. Exp Mol Pathol 1978;29:326-41.
22. Jeffery PK, Ayers MM, Rogers DF. The mechanisms in control of bronchial mucus cell hyperplasia. In: Chantler EN, Elder JB, Elstein M, eds. Mucus in health and disease. New York: Plenum, 1982:300-409.
23. Ayers MM, Jeffery PK. Proliferation and differentiation in mammalian airway epithelium. Eur Respir J 1988;1:58-80.
24. Basbaum C, Gallup M, Gum J, et al. Modification of mucin gene expression in the airways of rats exposed to sulfur dioxide. Biorheology 1990;27:485-9.
25. Jany B, Gallup M, Tsuda T, Basbaum C. Mucin gene expression in rat airways after infection and irritation. Biochem Biophys Res Commun 1991;181:1-8.
26. Harkema JR, Hotchkiss J. In vivo effects of endotoxin on intraepithelial mucosubstances in rat pulmonary airways: quantitative histochemistry. Am J Pathol 1992;141:307-17.
27. Steiger D, Hotchkiss J, Bajaj L, et al. Concurrent increases in the storage and release of mucin-like molecules by rat airway epithelial cells in response to bacterial endotoxin. Am J Respir Cell Mol Biol 1995;12:307-14.
28. Rose AS, Prazma J, Randell SH, et al. Nitric oxide mediates mucin secretion in endotoxin-induced otitis media with effusion. Otolaryngol Head Neck Surg 1997;116:308-16.
29. Dabbagh K, Takeyama K, Lee HM, et al. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol 1999;162:6233-7.
30. Hunter SE, Singla AK, Prazma J, et al. Mucin production in the middle ear in response to lipopolysaccharides. Otolaryngol Head Neck Surg 1999;120:884-8.
31. Leth N, Tos M. Middle ear ventilation after acute otitis media. ORL J Otorhinolaryngol Relat Spec 1977;39:278-84.
32. Ohashi Y, Nakai Y, Ikeoka H, et al. Functional disorder of eustachian tube in experimental otitis media with effusion after inoculation of bacterial endotoxin. Ann Otol Rhinol Laryngol 1988;97:422-6.
33. Rhee CK, Jang YJ, Jeong PS, et al. The effects of leukotriene and its inhibitor on the mucociliary clearance of the eustachian tube in guinea pigs. In: Tos M, Thomsen J, Balle V, eds. Otitis media today. The Hague, The Netherlands: Kugler Publications, 1999:199-203.
34. Majima Y, Sakakura Y, Hamaguchi Y, et al. Rheological properties of middle ear effusion and their role on mucociliary clearance. Auris Nasus Larynx 1985;12(Suppl 1):S129-31.
35. Sade J, Luntz M. Eustachian tube lumen: comparison between normal and inflamed specimens. Ann Otol Rhinol Laryngol 1989;98:630-4.
36. Larsen PL, Lundgren JD, Egeberg J. The whole-mount method as a technique for measuring experimental changes in airway goblet cell number. APMIS 1989;97:1141-5.
37. Rogers DF, Jeffery PK. Inhibition of cigarette smoke-induced airway secretory cell hyperplasia by indomethacin, dexamethasone, prednisolone or hydrocortisone in the rat. Exp Lung Res 1986;10:285-98.
38. Ahlstedt S, Enander I. Immune regulation of goblet cell development. Int Arch Allergy Appl Immunol 1987;82:357-60.
39. Christensen TG, Breuer R, Haddad CE, et al. Quantitative ultrastructural analysis of the relationship between cell growth, shape change, and mucosecretory differentiation in cultured hamster tracheal epithelial cells exposed to retinoic acid. Am J Respir Cell Mol Biol 1993;9:287-94.
40. Lin J, Kim Y, Lees C, et al. Effect of platelet-activating factor on secretion of mucous glycoprotein from chinchilla middle ear epithelial cells in vitro. Eur Arch Otorhinolaryngol 1995;252:92-6.
41. Lin J, Kim Y, Lees C, et al. Effect of lipoxygenase inhibition on mucous glycoprotein secretion from chinchilla middle ear epithelial cells in vitro. Ann Otol Rhinol Laryngol 1996;105:916-21.
42. Linder TE, Lim DJ, Demaria TF. Changes in the structure of the cell surface carbohydrates of the chinchilla tubotympanum after Streptococcus pneumoniae-induced otitis media. Microb Pathog 1992;13:293-303.
43. Reddy MS, Murphy TF, Faden H, et al. Middle ear mucin glycoprotein: purification and interaction with non-typeable Haemophilus influenzae and Moraxella catarrhalis. In: Lim D, Bluestone C, Casselbrandt ML, Klein JO, Ogra P, eds. Recent advances in otitis media. Ontario, Canada: BC Decker, 1996:307-10.
44. Jin CS, Majima Y, Hamaguchi Y, et al. Quantitative histochemical study of secretory cells after short term tubal obstruction in the cat. Acta Otolaryngol (Stockh) 1991;111:515-23.
45. Takeuchi K, Hamaguchi Y, Majima Y, et al. Contribution of biochemical components to the viscoelasticity of middle ear effusions in experimental otitis media. In: Mogi G, Honjo I, Ishii T, Takasaka T, eds. Recent advances in otitis media. Amsterdam, The Netherlands: Kugler Publications, 1994:683-6.
46. Haruna S, Schachern P, Paparella M, et al. Glycoconjugates in cats and chinchillas after eustachian tube obstruction. In: Lim D, Bluestone C, Casselbrandt ML, Klein JO, Ogra P, eds. Recent advances in otitis media. Ontario, Canada: BC Decker, 1996:545-8.
47. Hirano T, Kurono Y, Ichimiya I, et al. Influenza A virus infection and changes of lectin binding patterns in the nasopharyngeal mucosa in mice. In: Lim DJ, Bluestone C, Casselbrandt ML, Klein JO, Ogra P, eds. Recent advances in otitis media. Ontario, Canada: BC Decker, 1996:434-6.