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3
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0021675152
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(b) . Antimicrobial: González A.G., Estrada D.M., Martin J.D., Martin V.S., Perez C., Perez R. Tetrahedron. 40:1984;4109
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(1984)
Tetrahedron
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González, A.G.1
Estrada, D.M.2
Martin, J.D.3
Martin, V.S.4
Perez, C.5
Perez, R.6
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5
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0029888835
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Antifungal: Antimicrobial: Antiviral: Antitumor:
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(d) Antitumor: Miyamoto T., Sakamoto K., Arao K., Komori T., Higuchi R., Sasaki T. Tetrahedron. 52:1996;8187.
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(1996)
Tetrahedron
, vol.52
, pp. 8187
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Miyamoto, T.1
Sakamoto, K.2
Arao, K.3
Komori, T.4
Higuchi, R.5
Sasaki, T.6
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8
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0036178793
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Betancur-Galvis L., Zuluaga C., Arnó M., González M.A., Zaragozá R.J. J. Nat. Prod. 65:2002;189.
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(2002)
J. Nat. Prod.
, vol.65
, pp. 189
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Betancur-Galvis, L.1
Zuluaga, C.2
Arnó, M.3
González, M.A.4
Zaragozá, R.J.5
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9
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37049076659
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Compounds 8-10 were available from this work
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Abad A., Arnó M., Marín M.L., Zaragozá R.J. J. Chem. Soc., Perkin Trans. 1. 1993;1861. Compounds 8-10 were available from this work.
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(1993)
J. Chem. Soc., Perkin Trans. 1
, pp. 1861
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Abad, A.1
Arnó, M.2
Marín, M.L.3
Zaragozá, R.J.4
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11
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0001587313
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2O/pyridine) of pentacyclic spongianes usually leads to mixtures of products containing the corresponding pentacyclic acetate as well as products arising from opening of the hemiacetal system and acylation, see: Karuso P., Taylor W.C. Aust. J. Chem. 39:1986;1629
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(1986)
Aust. J. Chem.
, vol.39
, pp. 1629
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Karuso, P.1
Taylor, W.C.2
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14
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0003273340
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2O/pyridine) of pentacyclic spongianes usually leads to mixtures of products containing the corresponding pentacyclic acetate as well as products arising from opening of the hemiacetal system and acylation, see: Recently, DMAP-catalyzed benzoylation of aplyroseol-1 10 showed an improved yield of the corresponding opened hemiacetal benzoate, see: For our acetylation reactions, however, we used 4-pyrrolidinopyridine (4-PP) as catalyst
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(d) Recently, DMAP-catalyzed benzoylation of aplyroseol-1 10 showed an improved yield of the corresponding opened hemiacetal benzoate, see: Hambley T.W., Taylor W.C., Toth S. Aust. J. Chem. 50:1997;391. For our acetylation reactions, however, we used 4-pyrrolidinopyridine (4-PP) as catalyst.
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(1997)
Aust. J. Chem.
, vol.50
, pp. 391
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Hambley, T.W.1
Taylor, W.C.2
Toth, S.3
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17
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0033159403
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(c) Betancur-Galvis L.A., Saez J., Granados H., Salazar A., Ossa J.E. Mem. Inst. Oswaldo Cruz. 94:1999;531.
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(1999)
Mem. Inst. Oswaldo Cruz.
, vol.94
, pp. 531
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Betancur-Galvis, L.A.1
Saez, J.2
Granados, H.3
Salazar, A.4
Ossa, J.E.5
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18
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85031151280
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We believe that pure compound 6 is in fact even more active assuming that the 25% impurity present in 6 is an acetylated pentacyclic compound which would not be active, since we have demonstrated that acetylation of the hydroxyl group of the hemiacetal system in pentacyclic spongianes leads to a remarkable loss of cytotoxicity. Unfortunately, a pure sample of 6 was not available to confirm this statement.
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21
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85031155641
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Compounds 1, 2, 5, 6, 7 and 10 were tested in in vitro translation systems derived from both mammalian cells (Krebs cells) and bacterial cells (Escherichia coli) for inhibition of eukaryotic protein synthesis (at 50 μM final concentration). None of the compounds tested showed a significant effect of protein synthesis (greater than 2-fold) in either system, indicating that they are not active on this process.
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