Acute psychotic reaction caused by topical cyclopentolate use for cycloplegic refraction before refractive surgery: Case report and review of the literature

Journal of Cataract and Refractive Surgery

Volumn 29, Issue 5, 2003, Pages 1026-1030

  Mirshahi, Alireza ^b   Kohnen, Thomas ^a  

^a GOETHE UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPENTOLATE; PILOCARPINE;

ACCOMMODATION PARALYSIS; ACUTE PSYCHOSIS; ADULT; ARTICLE; CASE REPORT; DROWSINESS; DRUG INDUCED DISEASE; EYE REFRACTION; EYE SURGERY; FATIGUE; FEMALE; HUMAN; HYPERMETROPIA; NAUSEA; PARESTHESIA; PRIORITY JOURNAL; VERTIGO;

EID: 0038102584     PISSN: 08863350     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0886-3350(02)01651-6     Document Type: Article

References (32)

1. Sugar A, Rapuano CJ, Culbertson WW, et al. Laser in situ keratomileusis for myopia and astigmatism: safety and efficacy; a report by the American Academy of Ophthalmology. Ophthalmology 2002; 109:175-187
2. Gordon DM, Ehrenberg MH. Cyclopentolate hydrochloride: a new mydriatic and cycloplegic agent; a pharmacologic and clinical evaluation. Am J Ophthalmol 1954; 38:831-838
3. Binkhorst RD, Weinstein GW, Baretz RM, Clahane AC. Psychotic reaction induced by cyclopentolate (cyclogyl); results of a pilot study and a double-blind study. Am J Ophthalmol 1963; 55:1243-1245
4. Lovasik JV. Pharmacokinetics of topically applied cyclopentolate HCl and tropicamide. Am J Optom Physiol Opt 1986; 63:787-803
5. Huismans H. Intoxikationspsychose nach Cyclopentolat-HCL (Zyklolat). Klin Monatsbl Augenheilkd 1979; 175:100-102
6. Kellner U, Esser J. Akute Psychose durch Intoxikation mit Cyclopentolat. Klin Monatsbl Augenheilkd 1989; 194:458-461
7. Simcoe CW. Cyclopentolate (Cyclogyl) toxicity; report of a case. Arch Ophthalmol 1962; 67:406-408
8. Beswick JA. Psychosis from cyclopentolate [letter]. Am J Ophthalmol 1962; 53:879-880
9. Mark HH. Psychotogenic properties of cyclopentolate. JAMA 1963; 186:430-431
10. Praeger DL, Miller SN. Toxic effects of cyclopentolate (cyclogel); report of a case. Am J Ophthalmol 1964; 58: 1060-1061
11. Carpenter WT Jr. Precipitous mental deterioration following cycloplegia with 0.2% cyclopentolate HCl. Arch Ophthalmol 1967; 78:445-447
12. Schmidt I. Two patients with unusual reaction to drugs used in optometric practice. Am J Optom Arch Am Acad Optom 1970; 47:312-315
13. Adcock EW 3rd. Cyclopentolate (Cyclogyl) toxicity in pediatric patients. J Pediatr 1971; 79:127-129
14. Kennerdell JS, Wucher FP. Cyclopentolate associated with two cases of grand mal seizure. Arch Ophthalmol 1972; 87:634-635
15. Ostler HB. Cycloplegics and mydriatics; tolerance, habituation, and addiction to topical administration. Arch Ophthalmol 1975; 93:432-433
16. Awan KJ. Systemic toxicity of cyclopentolate hydrochloride in adults following topical ocular instillation. Ann Ophthalmol 1976; 8:803-806
17. Shihab ZM. Psychotic reaction in an adult after topical cyclopentolate. Ophthalmologica 1980; 181:228-230
18. Khurana AK, Ahluwalia BK, Rajan C, Vohra AK. Acute psychosis associated with topical cyclopentolate hydrochloride [letter]. Am J Ophthalmol 1988; 105:91
19. Fitzgerald DA, Hanson RM, West C, et al. Seizures associated with 1% cyclopentolate eyedrops. J Pediatr Child Health 1990; 26:106-107
20. Sato EH, de Freitas D, Foster CS. Abuse of cyclopentolate hydrochloride (Cyclogyl) drops [letter]. N Engl J Med 1992; 326:1363-1364
21. Mwanza J-CK. Cyclopentolate and grand mal seizure. Bull Soc Belge Ophtalmol 1999; 273:17-18
22. Bhatia SS, Vidyashankar C, Sharma RK, Dubey AK. Systemic toxicity with cyclopentolate eye drops. Indian Pediatr 2000; 37:329-331
23. Kaila T, Huupponen R, Salminen L, Iisalo E. Systemic absorption of ophthalmic cyclopentolate [letter]. Am J Ophthalmol 1989; 107:562-564
24. Haaga M, Kaila T, Salminen L, Ylitalo P. Systemic and ocular absorption and antagonist activity of topically applied cyclopentolate in man. Pharmacol Toxicol 1998; 82:19-22
25. Salminen L. Review: systemic absorption of topically applied ocular drugs in humans. J Ocul Pharmacol 1990; 6:243-249
26. Lahdes K, Huupponen R, Kaila T, et al. Systemic absorption of ocular cyclopentolate in children. Ger J Ophthalmol 1992; 1:16-18
27. Lahdes K, Huupponen R, Kaila T, et al. Plasma concentrations and ocular effects of cyclopentolate after ocular application of three formulations. Br J Clin Pharmacol 1993; 35:479-483
28. Lahdes KK, Huupponen RK, Kaila TJ. Ocular effects and systemic absorption of cyclopentolate eyedrops after canthal and conventional application. Acta Ophthalmol (Copenh) 1994; 72:698-702
29. Gilman AG, Rall TW, Nies AS, Taylor P, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed. New York, NY, Pergamon Press, 1990
30. Awan KJ. Adverse systemic reactions of topical cyclopentolate hydrochloride. Ann Ophthalmol 1976; 8:695-698
31. Egashira SM, Kish LL, Twelker JD, et al. Comparison of cyclopentolate versus tropicamide cycloplegia in children. Optom Vis Sci 1993; 70:1019-1026
32. Twelker JD, Mutti DO. Retinoscopy in infants using a near noncycloplegic technique, cycloplegia with tropicamide 1%, and cycloplegia with cyclopentolate 1%. Optom Vis Sci 2001; 78:215-222