Lack of effect of fluticasone propionate aqueous nasal spray on the hypothalamic-pituitary-adrenal axis in 2- and 3-year-old patients

Pediatrics

Volumn 112, Issue 1 I, 2003, Pages 96-100

  Galant, Stanley P ^a   Melamed, Isaac R ^b   Nayak, Anjuli S ^c   Blake, Kathryn V ^d   Prillaman, Barbara A ^e   Reed, Kenneth D ^e   Cook, Cindy K ^e   Philpot, Edward E ^e   Rickard, Kathleen A ^e  

^a Clinical Trials of Orange County   (United States)

^b Child First Pediatrics   (United States)

^c Allerg and Clin Immunol Assoc   (United States)

^d NEMOURS CHILDREN S CLINIC   (United States)

^e GLAXOSMITHKLINE   (United States)

Author keywords

Allergic rhinitis; Children <4 years old; FP200 QD nasal spray; HPA axis

Indexed keywords

FLUTICASONE PROPIONATE; HYDROCORTISONE; PLACEBO;

ALLERGIC RHINITIS; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; COMMON COLD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; CREATININE URINE LEVEL; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG TOLERABILITY; EPISTAXIS; FEMALE; FEVER; HEADACHE; HUMAN; HYDROCORTISONE URINE LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NOSE CONGESTION; OTITIS MEDIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINORRHEA; STOMACH PAIN; TOOTH PAIN; UPPER RESPIRATORY TRACT INFECTION; VOMITING; WHEEZING;

ADMINISTRATION, INTRANASAL; ANDROSTADIENES; ANTI-ALLERGIC AGENTS; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL;

EID: 0038080946     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: 10.1542/peds.112.1.96     Document Type: Article

References (27)

1. Dykewicz MS, Fineman S. Executive summary of Joint Task Force Practice Parameters on Diagnosis and Management of Rhinitis. Ann Allergy Asthma Immunol. 1998;81:463-468
2. Van Cauwenberge P, Bachert C, Passalacqua G, et al. Consensus statement on the treatment of allergic rhinitis. Allergy. 2000;55:116-134
3. International Rhinitis Management Working Group. International Consensus Report on the diagnosis and management of rhinitis. Allergy. 1994;49(suppl 19):1-34
4. Schimmer BP, Parker KL. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Hardman JG, Limbird LE, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill; 1996:1459-1485
5. Allen DB. Systemic effects of intranasal steroids: an endocrinologist's perspective. J Allergy Clin Immunol. 2000;106:S179-S190.
6. Grossman J, Banov C, Bronsky EA, et al. Fluticasone propionate aqueous nasal spray is safe and effective for children with seasonal allergic rhinitis. Pediatrics. 1993;92:594-599
7. Fluticasone Propionate Collaborative Pediatric Working Group. Treatment of seasonal allergic rhinitis with once-daily intranasal fluticasone propionate therapy in children. J Pediatr. 1994;125:628-634
8. Richards DH, Milson CM. Fluticasone propionate: a well-tolerated and effective treatment for perennial rhinitis in children aged 4-11 years. Pediatr Allergy Immunol. 1996;7:35-43
9. Ngamphaiboon J, Thepchatri A, Chatchatee P, et al. Fluticasone propionate aqueous nasal spray for perennial allergic rhinitis in children. Ann Allergy Asthma Immunol. 1997;78:479-484
10. Ratner PH, Paull BR, Findlay SR, et al. Fluticasone propionate given once daily is as effective for seasonal allergic rhinitis as beclomethasone dipropionate given twice daily. J Allergy Clin Immunol. 1992;90:285-291
11. Howland WC. Fluticasone propionate: topical or systemic effects? Clin Exper Allergy. 1996;26:18-22
12. van As A, Bronsky EA, Dockhorn RJ, et al. Once-daily fluticasone propionate is as effective for perennial allergic rhinitis as twice daily beclomethasone dipropionate. J Allergy Clin Immunol. 1993;91:1146-1154
13. LaForce CF, Dockhorn RJ, Findlay SR, et al. Fluticasone propionate: an effective alternative treatment for seasonal allergic rhinitis in adults and adolescents. J Fam Pract. 1994;38:145-152
14. Nathan RA, Bronsky EA, Fireman P, et al. Once daily fluticasone propionate aqueous nasal spray is an effective treatment for seasonal allergic rhinitis. Ann Allergy. 1991;67:332-338
15. Munk ZM, Pearlman D, Graft D, et al. Intranasal fluticasone propionate is effective and well-tolerated in adolescents with seasonal allergic rhinitis. Pediatr Asthma Allergy Immunol. 1994;8:39-46
16. Dockhom RJ, Paull BR, Meltzer EO, et al. Once- versus twice-daily fluticasone propionate aqueous nasal spray for seasonal allergic rhinitis. Am J Rhinology. 1993;7:77-83
17. Banov CH, Woehler TR, LaForce CF, et al. Once daily intranasal fluticasone propionate is effective for perennial allergic rhinitis. Ann Allergy. 1994;73:240-246
18. Bronsky E, Dockhom R, Meltzer E, et al. Fluticasone propionate aqueous nasal spray compared with terfenadine tablets in the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol. 1996;97:915-921
19. van Bavel J, Findlay SR, Hampel FC, et al. Intranasal fluticasone propionate is more effective than terfenadine tablets for seasonal allergic rhinitis. Arch Intern Med. 1994;154:2699-2704
20. Stricker W, Klimas J, Mendelson L, et al. Intranasal fluticasone propionate is more effective than astemizole for seasonal allergic rhinitis. Ann Allergy. 1994;72:86
21. Vargas R, Dockhorn RJ, Findlay R, et al. Effect of fluticasone propionate aqueous nasal spray on the hypothalamic-pituitary axis. J Allergy Clin Immunol. 1998;102:191-197
22. Flonase (fluticasone propionate) Nasal Spray [package insert]. Research Triangle Park, NC: Glaxo Wellcome Inc; 2000
23. Wilson AM, McFarlane LC, Lipworth BJ. Effects of repeated once daily dosing of three intranasal corticosteroids on basal and dynamic measures of hypothalamic-pituitary-adrenal-axis activity. J Allergy Clin Immunol. 1998;101:470-474
24. Knutsson U, Stierna P, Marcus C, et al. Effects of intranasal glucocorticoids on endogenous glucocorticoid peripheral and central function. J Endocrinol. 1995;144:301-310
25. Bachert C. Safety of intranasal steroids. J Allergy Clin Immunol. 1999;103:353-354
26. Bachert C, Lukat K-F, Lange B. Short-term use of intranasal corticosteroids: lack of systemic effect. J Allergy Clin Immunol. 2002;109:573-574
27. Brannan MD, Herron JM, Affrime MB. Safety and tolerability of once-daily mometasone furoate aqueous nasal spray in children. Clin Ther. 1997;19:1330-1339