Transcriptional activities of cholecystokinin promoter haplotypes and their relevance to panic disorder susceptibility

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 118 B, Issue 1, 2003, Pages 32-35

  Ebihara, Mitsuru ^a   Ohba, Hisako ^a   Hattori, Eiji ^a   Yamada, Kazuo ^a   Yoshikawa, Takeo ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Luciferase assay; Microsatellite; Protective factor; Repressor; Synergism

Indexed keywords

CHOLECYSTOKININ; HYBRID PROTEIN; LUCIFERASE;

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE FREQUENCY; GENE FUNCTION; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; PANIC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPRESSOR GENE; TANDEM REPEAT; TRANSCRIPTION REGULATION; ALLELE; CELL CULTURE; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; GENOTYPE; METABOLISM; TRANSACTIVATION;

ALLELES; CHOLECYSTOKININ; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; LUCIFERASES; PANIC DISORDER; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; TANDEM REPEAT SEQUENCES; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0038078531     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.10058     Document Type: Article

References (17)

1. Bowen T, Norton N, Jacobsen NJO, Guy C, Daniels JK, Sanders RD, et al. 1998. Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder. Mol Psychiatry 3:67-71.
2. Bradwejn J, Koszycki D, Meterissian G. 1990. Cholecystokinin-tetrapeptide induces panic attacks in patients with panic disorder. Can J Psychiatry 35:83-85.
3. Bradwejn J, Koszycki D, Shriqui C. 1991. Enhanced sensitivity to cholecystokinin tetrapeptide in panic disorder. Clinical and behavioral findings. Arch Gen Psychiatry 48:603-610.
4. Costa GL, Bauer JC, McGowan B, Angert M, Weiner MP. 1996. Site-directed mutagenesis using a rapid PCR-based method. Methods Mol Biol 57: 239-248.
5. Croager EJ, Gout AM, Abraham LJ. 2000. Involvement of Sp1 and microsatellite repressor sequences in the transcriptional control of the human CD30 gene. Am J Pathology 156:1723-1731.
6. Crowe RR, Goedken R, Samuelson S, Wilson R, Nelson J, Noyes R. 2001. Genomewide survey of panic disorder. Am J Med Genet (Neuropsychiatr Genet) 105:105-109.
7. de Montigny C. 1989. Cholecystokinin tetrapeptide induces panic-like attacks in healthy volunteers: Preliminary findings. Arch Gen Psychiatry 46:511-517.
8. Fujii C, Harada S, Ohkoshi N, Hayashi A, Yoshizawa K, Ishizuka C, et al. 1999, Association between polymorphism of the cholecystokinin gene and idiopathic Parkinson's disease. Clin Genet 56:394-399.
9. Gogos JA, Karayiorgou M. 1996. Sequence-specific and length-dependent interaction of C2H2 zinc fingers and (TA)n microsatellites. Hum Genet 98:616-619.
10. Hansen TVO, Rehfeld JF, Nielsen FC. 2000. Function of the C-36 to T polymorphism in the human cholecystokinin gene promoter. Mol Psychiatry 5:443-447.
11. Hattori E, Ebihara M, Yamada K, Ohba H, Shibuya H, Yoshikawa T. 2001. Identification of a compound short tandem repeat stretch in the 5′-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia. Mol Psychiatry 6:465-470.
12. Kadonaga JT, Carner KR, Masiarz FR, Tjian R. 1987. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51:1079-1090.
13. Meloni R, Albanese V, Ravassard P, Treilhou F, Mallet J. 1998. A tetranucleotide polymorphic microsatellite, located in the first intron of the tyrosine hydroxylase gene, acts as a transcription regulatory element in vitro. Hum Mol Genet 7:423-428.
14. Mignotte V, Wall L, deBoer E, Grosveld F, Romeo PH. 1989. Two tissue-specific factors bind to the erythroid promoter of the human porphobilinogen deaminase gene. Nucleic Acids Res 17:37-54.
15. Nielsen FC, Pedersen K, Hansen TVO, Rourke IJ, Rehfeld JF. 1996. Transcriptional regulation of the human cholecystokinin gene: Composite action of upstream stimulatory factor, Sp1, and members of the CREB/ATF-AP-1 family of transcription factors. DNA Cell Biol 15:53-63.
16. Sham PC, Curtis D. 1995. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 59:97-105.
17. Shimajiri S, Arima N, Tanimoto A, Murata Y, Hamada T, Wang KY, Sasaguri Y. 1999. Shortened microsatellite d(CA)21 sequence down-regulates promoter activity of matrix metalloproteinase 9 gene. FEBS Lett 455:70-74.