Adjusting for population heterogeneity: A framework for characterizing statistical information and developing efficient test statistics

Genetic Epidemiology

Volumn 24, Issue 4, 2003, Pages 284-290

  Rabinowitz, Daniel ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Admixture; Association; Confounding; Disequilibrium; Efficiency; Family based; Haplotype; Identity by state; Linkage; Stratification; Transmission

Indexed keywords

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ARTICLE; DATA ANALYSIS; FAMILY; GENETIC HETEROGENEITY; GENOTYPE; POPULATION GENETICS; STATISTICAL ANALYSIS; STATISTICS; THEORY;

DATA INTERPRETATION, STATISTICAL; GENE FREQUENCY; GENETIC HETEROGENEITY; GENETICS, POPULATION; HUMANS; PEDIGREE;

EID: 0038077490     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/gepi.10231     Document Type: Article

References (17)

1. Babron M, Martinez M, Bonaiti-Pellie C, Clerget-Darpoux F. 1993. Linkage detection by the affected-pedigree-method: what is really tested? Genet Epidemiol 10:847-51.
2. Curtis D, Sham PC. 1995. A note on the application of the transmission disequilibrium test when a parent is missing. Am J Hum Genet 56:811-12.
3. Elston RC. 1998. Linkage and association. Genet Epidemiol 15:565-76.
4. Falk CT, Rubenstein P. 1987. Haplotype relative risks: an easy way to construct a proper control sample for risk calculations. Ann Hum Genet 51:227-33.
5. Freimer NB, Sandkuijl LA, Blower SM. 1993. Incorrect specification of marker allele frequencies: effects on linkage analysis. Am J Hum Genet 52:1102-10.
6. Gu C, Miller MD, Reich T. 1995. The affected-pedigree-member method revisited under population stratification. Psychiatr Genet 15:105-6.
7. Horvath S, Laird NM. 1998. A discordant-sibship test for disequilibrium and linkage: no need for parental data. Am J Hum Genet 63:1886-97.
8. Knapp M. 1999. The Transmission/disequilibrium test and parental-genotype reconstruction: the reconstruction-combined transmission/disequilibrium test. Am J Hum Genet 64:861-70.
9. Lake SL, Blacker D, Laird NM. 2000. Family-based tests of association in the presence of linkage. Am J Hum Genet 67:1515-25.
10. Rabinowitz D. 2002. Adjusting for population heterogeneity and misspecified haplotype frequencies when testing nonparametric null hypotheses in statistical genetics. J Am Stat Assoc 97:742-58.
11. Rabinowitz D, Laird N. 2000. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered 50:211-23.
12. Schaid DJ. 1996. General score tests for associations of genetic markers with disease using cases and their parents. Genet Epidemiol 13:423-49.
13. Spielman RS, Ewens WJ. 1998. A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am J Hum Genet 54:559-60.
14. Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-13.
15. Teng J, Risch N. 1999. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping. Genome Res 9:234-41.
16. Weinberg CR, Wilcox AJ, Lie RT. 1998. A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet 62:969-78.
17. Zhao H, Zhang S, Merikangas KR, Trixler M, Wildenauer DB, Sun F, Kidd KK. 2000. Transmission/disequilibrium tests using multiple tightly linked markers. Am J Hum Genet 67:234-41.