Trisomy 11 limited to trisomy 21 cells in a mosaic down syndrome child with acute myeloid leukemia

Medical and Pediatric Oncology

Volumn 41, Issue 1, 2003, Pages 69-70

  Punnett, Hope H ^a   Dampier, Carlton ^a  

^a ST CHRISTOPHER'S HOSPITAL FOR CHILDREN   (United States)

Author keywords

Acute myelogenous leukemia M7; Trisomy 11; Trisomy 21 mosaicism

Indexed keywords

ASPARAGINASE; CYCLOSPORIN A; CYTARABINE; ETOPOSIDE; IDARUBICIN; MITOXANTRONE; PREDNISONE; VINCRISTINE; ANTINEOPLASTIC AGENT;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW TRANSPLANTATION; DOWN SYNDROME; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; MOSAICISM; PRIORITY JOURNAL; REMISSION; TREATMENT OUTCOME; TRISOME 11; TRISOMY; TRISOMY 21; BONE MARROW; CASE REPORT; CHROMOSOME 11; GENETICS; KARYOTYPING; MALE; MYELOID LEUKEMIA; PATHOLOGY; PRESCHOOL CHILD; TUMOR RECURRENCE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 11; DOWN SYNDROME; HUMANS; KARYOTYPING; LEUKEMIA, MYELOID; MALE; MOSAICISM; NEOPLASM RECURRENCE, LOCAL; TRISOMY;

EID: 0038071677     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/mpo.10102     Document Type: Article

References (14)

1. Jadhav M, Gushing B, Özdemir Ö, et al. Clonal trisomy 11 in a child with acute leukemia: G banding vs. FISH. Med Pediatr Oncol 2001;37:475-476.
2. Ravindranath Y, Abella E, Krischer JP, et al. Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: Experience on Pediatric Oncology Group AML Study 8498. Blood 1992;2210-2214.
3. Heim S, Mitelman F. Cancer cytogenetics ed. 2; New York, NY: Wiley-Liss, Inc; 1995.
4. Taylor A. Cell selection in vivo in normal/G trisomic mosaics. Nature 1968;219:1028-1030.
5. Taysi K, Kohn G, Mellman WJ. Mosaic mongolism. II. Cytogenetic studies. J Pediatr 1970;76:880-885.
6. Iselius L, Jacobs P, Morton N. Leukaemia and transient leukaemia in Down syndrome. Hum Genet 1990;85:477-485.
7. Ferster A, Verhest A, Vamos E, et al. Leukemia in a trisomy 21 mosaic: Specific involvement of the trisomic cells. Cancer Genet Cytogenet 1986;20:109-113.
8. Teyssier JR, Behar C, Bajolle F, Potron G. Selective involvement of cells carrying extra chromosomes 21 in a child with acute non-lymphocytic leukaemia. Lancet 1984;1:290-291.
9. Čáp J, Izakovic V, Vojtaššák J. Juvenile Form der chronischen myeloischen Leukämie bei einem 3 6/12 jährigen Knaben mit Mosaikvorkommen der Trisomie 21 ohne Merkmale eines Down- Syndroms. Mschr Kinderheilk 1977;125:740-743.
10. Feingold E, Lamb NE, Sherman SL. Methods for genetic linkage analysis using trisomies. Am J Hum Genet 1995;56:475-483.
11. Abe K, Kajii T, Niikawa N. Disomic homozygosity in 21-trisomic cells; a mechanism responsible for transient myeloproliferative syndrome. Hum Genet 1989;82:313-316.
12. Shen JJ, Williams BJ, Zipursky A, et al. Cytogenetic and molecular studies of Down syndrome individuals with leukemia. Am J Hum Genet 1995;56:915-925.
13. Schnittger S, Kinkelin U, Schoch C, et al. Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML. Leukemia 2000;14:796-804.
14. Desangles F. 1997. +11 or trisomy 11 (solely). Atlas Genet Cytogenet Oncol Haematol. July. URL: 1997 http://www.infobiogen.fr/services/ chromcancer/Anomalies/tri11