Effects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivo

Breast

Volumn 12, Issue 2, 2003, Pages 142-149

  Desreux, Joelle ^a   Kebers, F ^a   Noel A ^a   Francart, D ^a   Van Cauwenberge, H ^a   Heinen, V ^a   Peyrollier, K ^a   Thomas, J L ^b   Bernard, A M ^b   Paris, J ^b   Delansorne, R ^b   Foidart, J M ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b NONE

Author keywords

Apoptosis; Breast cancer; Fibroadenoma; Nomegestrol acetate; Normal breast; Progestogen

Indexed keywords

GESTAGEN; NOMEGESTROL ACETATE; PLACEBO;

ADOLESCENT; ADULT; APOPTOSIS; BREAST CANCER; BREAST CELL; BREAST FIBROADENOMA; BREAST HYPERPLASIA; CANCER SURGERY; CELL PROLIFERATION; CELL SPECIFICITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; DRUG RESPONSE; DRUG WITHDRAWAL; EPITHELIUM CELL; FEMALE; FOLLICULAR PHASE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; LUTEAL PHASE; MENSTRUAL CYCLE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REVIEW; TUMOR CELL LINE;

EID: 0038070600     PISSN: 09609776     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9776(03)00003-1     Document Type: Article

References (41)

1. Dixit V M, Green D R, Reed J C et al. Apoptosis (special section). Science 1998; 281: 1301-1325.
2. Carson D A, Ribeiro J M. Apoptosis and disease. Lancet 1993; 341: 1251-1254.
3. Vogel P M, Georgiade N G, Fetter B F, Vogel F S, McCarty K S. The correlation of histologic changes in the human breast with the menstrual cycle. Am J Pathol 1981; 104: 23-34.
4. Mauvais-Jarvis P, Kuttenn F, Malet C, Gompel A. Antiestrogen action of progesterone in breast tissue. Breast Cancer Res Treat 1986; 8: 179-188.
5. Ferguson D J P, Anderson T J. Morphological evaluation of cell turnover in relation to the menstrual cycle in the "resting" human breast. Br J Cancer 1981; 44: 177-187.
6. Haslam S Z. Progesterone effects on deoxyribonucleic acid synthesis in normal mouse mammary glands. Endocrinology 1988; 122: 464-470.
7. Mark Cline J, Soderqvist G, Von Schoultz E, Lambert S, Von Schoultz B. Effect of hormone replacement therapy on the mammary gland of surgically postmenopausal cynomolgus macaques. Am J Obstet Gynecol 1996; 174: 93-100.
8. Masters R W, Drife J O, Scaribrick J J. Cyclic variation of DNA synthesis in human breast epithelium. J Natl Cancer Inst 1977; 58: 1263-1265.
9. Adams J M, Cory S. The Bcl-2 protein family: arbiters of cell survival. Apoptosis (special section). Science 1998; 281: 1322-1325.
10. Sabourin J, Martin A, Baruch J et al. Bcl-2 expression in normal human breast tissue during the menstrual cycle. Int J Cancer 1994; 59: 1-6.
11. Thompson E B. Apoptosis, steroid hormones. Mol Endocrinol 1994; 8: 665-673.
12. Tenniswood M P, Guenette R S, Lakins J, Mooibroek M, Wong P, Welsh J-E. Active cell death in hormone-dependent tissues. Cancer Metastasis Rev 1992; 11: 197-200.
13. Spencer S J, Cataldo N A, Jaffe R B. Apoptosis in the human female reproductive tract. Obstet Gynecol Surv 1996; 51: 314-323.
14. Catherino W H, Jordan V C. 1Nomegestrol acetate, a clinically useful 19-norprogesterone derivative which lacks estrogenic activity. J Steroid Biochem Mol Biol 1995; 55: 239-246.
15. Botella J, Duranti E, Duc I, Cognet A M, Delansorne R, Paris J. Inhibition of nomegestrol acetate and other synthetic progestins on proliferation and progesterone receptor content of T47-D human breast cancer cells. J Steroid Biochem Biol 1994; 30: 41-47.
16. Soule H D, Mc Grath C M. A simplified method for passage and long term growth of human mammary epithelial cells. In Vitro Cell Dev Biol 1986; 22: 6-12.
17. Gavrieli Y, Sherman Y, Ben-Sasson S A. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
18. Chang K J, Lee T Y, Linares-Cruz G, Fournier S, de Lignières B. Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo. Fertil Steril 1995; 663: 785-791.
19. Krajewska M, Wang H-G, Krajewski S et al. Immunohistochemical analysis of in vivo patterns expression of CPP32 (caspase-3), a cell death protease. Cancer Res 1997; 57: 1605-1613.
20. Hasegawa T I, Kamada S, Kamiike W et al. Involvement of CPP32/Yama (-like) proteases in Fas-mediated apoptosis. In Vitro Cell Dev Biol 1996; 56: 1713-1718.
21. Humblet C, Deman J, Franzen R, Greimers R, Boniver J, Defresne M P. Spontaneous and induced apoptosis after whole body radiation exposure: experimental approaches. Observations in radio-induced thymic lymphomagenesis. Stem Cells 1995; 13: 129-135.
22. Maquoi E, Nöel A, Frankenne F, Angliker H, Murphy G, Foidart J M. Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor. FEBS Lett 1998; 424: 262-266.
23. Glinsky G V, Glinsky V V, Ivanova A B, Hueser C J. Apoptosis and metastasis: increased apoptosis resistance of metastatic cancer cells is associated with the profound deficiency of apoptosis execution mechanisms. Cancer Lett 1997; 115: 185-193.
24. Sheets E E, Yeh J. The role of apoptosis in gynaecological malignancies. Ann Med 1997; 29: 121-126.
25. Allan D J, Howell A, Roberts S A et al. Reduction in apoptosis relative to mitosis in histologically normal epithelium accompanies fibrocystic damage and carcinoma in the premenopausal human breast. J Pathol 1992; 167: 25-32.
26. Meredith J E, Fazeli J B, Schwartz M A. The extracellular matrix as a cell survival factor. Mol Biol Cell 1993; 4: 953-961.
27. Ferguson J E, Schor A M, Howell A, Ferguson M J W. Changes in the extracellular matrix of the normal human breast during the menstrual cycle. Cell Tissue Res 1992; 268: 167-177.
28. Cunha G R. Role of mesenchymal-epithelial interactions in normal, abnormal development of the mammary gland and prostate. Cancer 1994; 74 [Suppl]: 1030-1044.
29. Xie J, Haslam S Z. Extracellular matrix regulates ovarian hormone-dependent proliferation of mouse mammary epithelial cells. Endocrinology 1997; 138: 2466-2473.
30. Boudreau N, Sympson C J, Werb Z, Bissel M J. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 1995; 267: 891-893.
31. Kandouz M, Lombet A, Perrot J-Y et al. Proapoptotic effects of antiestrogens, progestins and androgen in breast cancer cells. J Steroid Biochem Mol Biol 1999; 69: 463-471.
32. Formby B, Wiley T S. Progesterone inhibits growth and induces apoptosis in breast cancer cells: inverse effects on Bcl-2 and p53. Ann Clin Sci 1998; 28: 360-369.
33. Sutherland R L, Hall R E, Pang G Y N, Musgrove E A, Clarke C L. Effect of medroxyprogesterone acetate on proliferation and cell cycle kinetics of human mammary carcinoma cells. Cancer Res 1988; 48: 5084-5091.
34. Musgrove E A, Lee C S, Sutherland R L. Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos and c-myc genes. Mol Cell Biol 1991; 11: 5032-5043.
35. Musgrove E A, Hamilton J A, Lee C S, Sweeney K J, Watts C K, Sutherland R L. Growth factor, steroid and steroid antagonist regulation of cyclin gene expression associated with changes in T47-D human breast cancer cell cycle progression. Mol Cell Biol 1993; 13: 3577-3587.
36. Kipl. Mol Endocrinol 1997; 11: 1593-1607.
37. Lange C A, Richer J K, Horwitz K B. Hypothesis: progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals. Mol Endocrinol 1999; 13: 829-836.
38. Marti A, Feng Z, Jehn B et al. Expression and activity of cell cycle regulators during proliferation and programmed cell death in the mammary gland. Cell Death Differ 1995; 2: 277-283.
39. Pasqualini J R, Paris J, Sitruk-Ware R, Chetrite G, Botella J. Progestins and breast cancer. J Steroid Biochem Mol Biol 1998; 65: 225-235.
40. Hesch R D, Kenemans P. Hormonal prevention of breast cancer: proposal for a change in paradigm. Br J Obstet Gynaecol 1999; 106: 1006-1018.
41. Gompel A, Somaï S, Chaouat M et al. Hormonal regulation of apoptosis in breast cells and tissues. Steroids 2000; 65: 593-598.