Pulmonary perfusion quantified by electron-beam computed tomography: Effects of hypoxia and inhaled NO

European Respiratory Journal

Volumn 21, Issue 5, 2003, Pages 855-861

  Jones, A T ^a   Hansell, D M ^a   Evans, T W ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Computed tomography; Hypoxia; Pulmonary perfusion

Indexed keywords

NITRIC OXIDE;

ARTICLE; CLINICAL TRIAL; CONTRAST ENHANCEMENT; ELECTRON BEAM TOMOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYPOXIA; INHALATION; INTERMETHOD COMPARISON; LUNG PERFUSION; MEDICAL DOCUMENTATION; NORMAL HUMAN; OPTICAL RESOLUTION; OXYGEN CONCENTRATION; PRIORITY JOURNAL; SUPINE POSITION; TISSUE DISTRIBUTION;

ADMINISTRATION, INHALATION; ANOXIA; HUMANS; LUNG; NITRIC OXIDE; PULMONARY CIRCULATION; TOMOGRAPHY, X-RAY COMPUTED; VASODILATOR AGENTS;

EID: 0038056181     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.03.00085002     Document Type: Article

References (40)

1. Fishman AP. Hypoxia on the pulmonary circulation. How and where it acts. Circ Res 1976; 38: 221-231.
2. Von Euler US, Liljestrand G. Observations on the pulmonary arterial pressure in the cat. Acta Physiol Scand 1946; 12: 301-306.
3. Dantzker DR, Brook CJ, Dehart P, Lynch JP, Weg JG. Ventilation perfusion distributions in the adult respiratory distress syndrome. Am Rev Respir Dis 1979; 20: 1039-1052.
4. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide; physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 43: 109-142.
5. Frostell CG, Fratacci M, Wain JC, Zapol WM. Inhaled nitric oxide: A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 1991; 83: 2038-2047.
6. Pison U, Lopez FA, Heidelmeyer CF, Rossaint R, Falke KJ. Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction without impairing gas exchange. Anesthesiology 1993; 74: 1287-1292.
7. Frostell CG, Blomqvist H, Lundberg J, Zapol WM. Inhaled nitric oxide reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology 1993; 78: 427-435.
8. Hughes JMB, Glazier JE, Maloney JE, West JB. Effect of lung Volume on the distribution of pulmonary blood flow in man. Respir Med 1968; 4: 58-72.
9. West JB, Dollery CT, Naimark A. Distribution of blood flow in isolated lung; relation to vascular and alveolar pressures. J Appl Physiol 1964; 19: 713-724.
10. Glenny RW, Bernard S, Robertson HT, Hlastala MP. Gravity is an important but secondary determinant of regional pulmonary perfusion in upright primates. J Appl Physiol 1999; 86: 623-632.
11. Glenny RW, Lamm WJE, Albert RK, Robertson HT. Gravity is a minor determinant of pulmonary blood flow distribution. J Appl Physiol 1991; 71: 620-629.
12. Jones AT, Hansell DM, Evans TW. Pulmonary perfusion in supine and prone positions: an electron-beam computed tomography study. J Appl Physiol 2001; 90: 1342-1348.
13. Fishman AP, Fritts HW, Cournand A. Effects of acute hypoxia and exercise on the pulmonary circulation. Circulation 1960; 22: 204-215.
14. Naeije RL, Melot C, Mols P, Hallemans R. Effects of vasodilators on hypoxic vasoconstriction in normal man. Chest 1982; 82: 404-410.
15. Wolfkiel CJ, Fergusson JL, Chomka EV, et al. Measurement of myocardial blood flow by ultrafast computed tomography. Circulation 1987; 76: 1262-1273.
16. Wolfkiel CJ, Rich SA. Analysis of regional pulmonary enhancement in dogs using ultrafast computed tomography. Invest Radiol 1992; 27: 211-216.
17. Tajik JK, Kugelmass SD, Hoffman EA. An automated method for relating regional pulmonary structure and function: integration of dynamic multislice CT and thin slice high-resolution CT. SPIE Proceed 1993; 1905: 339-350.
18. Wolfkiel CJ, Fergusson JL, Chomka EV, Law WR, Brundage BH. Determination of cardiac output by ultrafast computed tomography. Am J Physiol Imaging 1986; 1: 117-123.
19. Feldman HA. Families of lines: random effects in linear regression analysis. J Appl Physiol 1988; 64: 1721-1732.
20. Peck WW, Slutsky RA, Hackney DB, Mancini GBJ, Higgins CB. Effects of contrast on pulmonary hemodynamics: comparison of ionic and non-ionic agents. Radiology 1983; 149: 371-374.
21. Slutsky RA, Hackney DB, Peek WW, Higgins CB. Extravascular lung water: effects of ionic and non-ionic contrast media. Radiology 1983; 149: 375-378.
22. Brudin LH, Rhodes SO, Valind SO, Jones T, Hughes JMB. Interrelationships between regional blood flow, blood volume, and ventilation in supine humans. J Appl Physiol 1998; 76: 1205-1210.
23. Reed JH, Wood EH. Effect of body position on vertical distribution of pulmonary blood flow. J Appl Physiol 1970; 28: 303-311.
24. Larsen RL, Bridges CR, Beck KC, Hoffman EA. Regional pulmonary blood flow via cine x-ray computed tomography (abstract). FASEB J 1990; 4: 1074.
25. Ludman PF, Darby M, Tomlinson N, Poole-Wilson PA, Rees S. Cardiac flow measurement by ultrafast CT: Validation of continuous and pulsatile flow. J Comput Assist Tomogr 1992; 16: 795-803.
26. Rumberger JA, Feiring AJ, Lipton MJ, Higgins CB, Ell SR, Marcus M. Use of ultrafast computed tomography to quantitate regional myocardial perfusion: A preliminary report. J Am Coll Cardiol 1987; 9: 59-69.
27. Hedenstierna G, White FC, Mazzone R, Wagner PD. Redistribution of pulmonary blood flow in the dog with PEEP ventilation. J Appl Physiol 1979; 46: 278-287.
28. Hedenstierna G, White FC, Wagner PD. Spatial distribution of pulmonary blood flow in the dog with PEEP ventilation. J Appl Physiol 1979; 47: 938-946.
29. Kallas HJ, Domino KB, Glenny RW, Anderson EA, Hlastala MP. Pulmonary blood flow redistribution with low levels of positive end-expiratory pressure. Anesthesiology 1998; 88: 1291-1299.
30. Theissen JL, Fischer SR, Traber LD, Traber DL. Pulmonary blood now regulation: influence of positive pressure ventilation. Respir Physiol 1995; 102: 251-260.
31. Rossaint R, Falke KJ, Lopez EA, Slama K, Pison U, Zapol WM. Inhaled nitric oxide in adult respiratory distress syndrome. N Engl J Med 1993; 328: 399-405.
32. Dawson A. Regional pulmonary blood flow in sitting and supine man during and after acute hypoxia. J Clin Invest 1969; 8: 301-310.
33. Dugard A, Naimark A. Effect of hypoxia on the distribution of pulmonary blood flow. J Appl Physiol 1967; 23: 663-671.
34. Neumann PH, Kivlen CM, Johnson A, Minnear FL, Malik AB. Effect of alveolar hypoxia on regional pulmonary perfusion. J Appl Physiol 1984; 56: 338-342.
35. Wagner WW, Latham LP. Pulmonary capillary recruitment during airway hypoxia in the dog. J Appl Physiol 1975; 39: 900-905.
36. Wagner WW, Latham LP, Capen RL. Capillary recruitment during airway hypoxia: role of pulmonary artery pressure. J Appl Physiol 1979; 47: 383-387.
37. Capen RL, Wagner WW. Intrapulmonary blood flow redistribution during hypoxia increases gas exchange surface area. J Appl Physiol 1982; 52: 1575-1581.
38. Engel LA, Prefaut C. Cranio-caudal distribution of inspired gas and pulmonary perfusion in supine man. Respir Physiol 1981; 45: 43-53.
39. Orphanidou D, Hughes JMB, Meyers MJ, Al-Suhali AR, Henderson B. Tomography of regional ventilation and perfusion using kryptonite 81m in normal subjects and asthmatic patients. Thorax 1986; 41: 542-551.
40. Fowler KT, Reed J. Effect of alveolar hypoxia on zonal distribution of pulmonary blood flow. J Appl Physiol 1963; 18: 244-250.