Progenitor cells divide symmetrically to generate new colony-forming cells and clonal heterogeneity

British Journal of Haematology

Volumn 121, Issue 4, 2003, Pages 643-648

  Marley, Stephen B ^a   Lewis, John L ^a,b   Gordon, Myrtle Y ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Clonogenic; Extinction; Self renewal; Stem cells; Stochastic

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 3;

ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CELL REGENERATION; CLONAL VARIATION; CLONOGENIC ASSAY; COLONY FORMING CELL; GENETIC HETEROGENEITY; HEMATOPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STEM CELL; STOCHASTIC MODEL;

CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; CLONE CELLS; COLONY-FORMING UNITS ASSAY; HEMATOPOIETIC STEM CELLS; HUMANS;

EID: 0038054134     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04338.x     Document Type: Article

References (24)

1. Brummendorf, T.H., Dragowska, W., Zijlmans, J.M., Thornbury, G. & Lansdorp, P.M. (1998) Asymmetric divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells. Journal of Experimental Medicine, 188, 1117-1124.
2. Cho, R.H. & Muller-Sieberg, C.E. (2000) High frequency of long-term culture initiating cells retain in vivo repopulation and self-renewal capacity. Experimental Hematology, 28, 1080-1086.
3. Ema, H., Takano, H., Sudo, K. & Nakauchi, H. (2000) In vitro self-renewal of hematopoietic stem cells. Journal of Experimental Medicine, 192, 1281-1288.
4. Enver, T., Heyworth, C.M. & Dexter, T.M. (1998) Do stem cells play dice? Blood, 92, 348-351.
5. Goff, J.P., Shields, D.S. & Greenbergen, J.S. (1998) Influence of cytokines on the growth kinetics and immunophenotype of daughter cells resulting from the first division of Cd34+Thy-1+lin- cells. Blood, 92, 4098-4107.
6. Gordon, M.Y. & Blackett, N.M. (1994) Routes to repopulation: a unification of the stochastic model and stem cell subpopulations. Leukemia, 8, 1068-1073.
7. Gordon, M.Y. & Blackett, N.M. (1995) Some factors determining the minimum number of cells required for successful clinical engraftment. Bone Marrow Transplantation, 15, 659-662.
8. Gordon, M.Y. & Blackett, N.M. (1998) Reconstruction of the hematopoietic system after stem cell transplantation. Cell Transplantation, 7, 339-344.
9. Horvitz, H.R. & Herskowitz, I. (1992) Mechanisms of asymmetric cell division: two Bs or not two Bs. that is the question. Cell, 68, 237-255.
10. Huang, S., Law, P., Francis, K., Palsson, B.O. & Ho, A.D. (1999) Symmetry of initial divisions among primitive hematopoietic progenitors is independent of ontogenic age and regulatory molecules. Blood, 94, 2595-2604.
11. Lewis, J.L., Blackett, N.M. & Gordon, M.Y. (1994) The kinetics of colony formation by CFU-GM in vitro. British Journal of Haematology, 88, 440-442.
12. Loeffler, M. & Potten, C.S. (1997) Stem cells and cellular pedigrees: a conceptual introduction. In: Stem Cells (ed. by C. Potten). pp. 1-20. Academic Press, London.
13. Metcalf, D. (1998) Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation. Blood, 92, 345-347.
14. Morrison, S.J., Shah, N.M. & Anderson, D.J. (1997) Regulatory mechanisms in stem cell biology. Cell, 88, 287-298.
15. Muller-Sieberg, C.E., Cho, R.H., Thoman, M., Adkins, B. & Sieberg, S.B. (2002) Deterministic regulation of hematopoietic stem cell self-renewal and differentiation. Blood, 100, 1302-1309.
16. Peters, S.O., Kittler, E.L., Ramshaw, H.S. & Quesenberry, P.J. (1995) Murine marrow cells expanded in culture with IL-3, IL-6, IL-11 and SCF acquire an engraftment defect in normal hosts. Experimental Hematology, 23, 461-469.
17. Peters, S.O., Kittler, E.L., Ramshaw, H.S. & Quesenberry, P.J. (1996) Ex vivo expansion of murine marrow cells with interleukin-3, interleukin-6, interleukin-11 and stem cell factor leads to impaired engraftment in irradiated hosts. Blood, 87, 30-37.
18. Potten, C.S. & Loeffler, M. (1990) Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development, 110, 1001-1120.
19. Punzel, M. & Ho, A.D. (2001) Divisional history and pluripotency of human hematopoietic stem cells. Annals of the New York Academy of Sciences., 938, 72-82.
20. Punzel, M., Zhang, T., Liu, D., Eckstein, V. & Ho, A.D. (2002) Functional analysis of initial cell divisions defines the fate of individual human CD34+CD38- cells. Experimental Hematology, 30, 464-472.
21. Quesenberry, P.J., Colvin, G.A. & Lambert, J.-F. (2002) The chiaroscuro stem cell: a unified stem cell theory. Blood, 100, 4266-4271.
22. Slayton, W.B., Mojica, M.P., Pierce, L.J. & Spangrude, G.J. (2001) Observations of residual differentiation potential during lineage commitment. Annals of the New York Academy of Sciences, 938, 157-166.
23. Solberg, L.A. (2001) Physiology of myeloproliferation. Seminars in Hematology, 38, 5-9.
24. Vogel, H., Niewisch, H. & Matioli, M. (1969) Stochastic development of stem cells. Journal of Theoretical Biology, 22, 249-270.