The effects of diethylcarbamazine on the ultrastructure of microfilariae of Wuchereria bancrofti

Parasitology

Volumn 126, Issue 6, 2003, Pages 551-554

  Florencio M S ^b   Peixoto, C A ^a,c  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Diethylcarbamazine; Microfilariae; Mode of action; Ultrastructure; Wuchereria bancrofti

Indexed keywords

DIETHYLCARBAMAZINE;

ANIMAL CELL; ARTICLE; CELL ORGANELLE; CELL STRUCTURE; CELL ULTRASTRUCTURE; CELL VACUOLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOLYSIS; DISEASE SEVERITY; DOSE TIME EFFECT RELATION; DRUG EFFECT; ELECTRON TRANSPORT; ENDOPLASMIC RETICULUM; IN VITRO STUDY; LAMELLAR BODY; MEMBRANE DAMAGE; MICROFILARIA; MICROFILARIA SHEATH; MORPHOLOGICAL ADAPTATION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; SUBCUTANEOUS TISSUE; WUCHERERIA BANCROFTI;

ANIMALS; APOPTOSIS; DIETHYLCARBAMAZINE; FILARIASIS; FILARICIDES; HUMANS; MICROFILARIA; MICROSCOPY, ELECTRON; ORGANELLES; WUCHERERIA BANCROFTI;

ANIMALIA; HYPODERRIS; PROTOZOA; WUCHERERIA; WUCHERERIA BANCROFTI;

EID: 0038049750     PISSN: 00311820     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. BIRD, M. M. (2000). The effects of diethylcarbamazine on the morphology and ultrastructure of foetal mouse cerebellar neurons in culture. Journal of Electron Microscopy 49, 669-674.
2. DENHAM, D. A., SUSWILLO, R. R., ROGERS, R. & MCGREEVY, P. B. (1978). Studies with Brugia malayi 17. The anthelmintic effects of diethylcarbamazine. Journal of Parasitology 64, 463-468.
3. FUJIMAKI, Y., EHARA, M., KIMURA, E., SHIMIDA, M. & AOKI, Y. (1990). Diethylcarbamazine, antifilarial drug, inhibits microtubule polymerization and disrupts preformed microtubules. Biochemical Pharmacology 39, 851-856.
4. FUJIMAKI, Y., SHIMADA, S., KIMURA, E. & AOKI, Y. (1988). DEC-inhibited development of third-stage Brugia pahangi in vitro. Parasitology Research 74, 299-300.
5. FREEDMAN, D.O., ALMEDIA FILHO, P. J., BESH, S., MARIA E. SILVA, M. C., BRAGA C. & MACIEL, A. (1994). Lymphoscintigraphic analysis of lymphatic abnormalities in symptomatic and asymptomatic human filariasis. Journal of Infection and Diseases 170, 927-933.
6. GIBSON, D. W., CONNOR, D. H., BROWN, H. L., FUGLSANG, H., ANDERSON, J., DUKE, B. O. L. & BUCK, A. A. (1976). Onchocercal dermatitis: ultrastructural studies of microfilariae and host tissues, before and after treatment with diethylcarbamazine (Hetrazan). American Journal of Tropical Medicine and Hygiene 25, 74-87.
7. HAWKING, F. (1979). Diethylcarbamazine and new compounds for the treatment of filariasis. Advances in Pharmacology and Chemotherapy 16, 129-194.
8. HAWKING, F. & LAURIE, W. (1949). Action of hetrazan on filariasis and onchocerciasis. Lancet 2, 146-147.
9. HAWKING, F., SEWELL, P. & THURSTON, J. P. (1948). Mode of action of hetrazan in filariasis. Lancet 2, 730-731.
10. HAWKING, F., SEWELL, P. & THURSTON, J. P. (1950). The mode of action of hetrazan on filarial worms. British Journal of Pharmacology 5, 217-238.
11. HEWITT, R. I. S., WHITE, E., WALLACE, W. S., STEWART, W. H., KUSHNER, H. & SUBBA RAO, Y. (1947). Experimental chemotherapy of filariasis. II. Effect of piperazine derivatives against naturally acquired filarial infections in cotton rats and dogs. Journal of Laboratory and Clinical Medicine 32, 1304-1313.
12. JOHNSON, P., MACKENZIE, C. D., DENHAM, D. A. & SUSWILLO, R. R. (1988). The effect of diethylcarbamazine on the in vitro serum-mediated adherence of feline granulocytes to microfilarie of Brugia pahangi. Tropical Medicine and Parasitology 39, 291-294.
13. MAIZELS, R. M. & DENHAM, D. A. (1992). Diethylcarbamazine (DEC): Immunopharmacological interactions of anti-filarial drug. Parasitology 105, (Suppl.) S49-S60.
14. MCLAREN, D. J. (1992). Ultrastructural studies on microfilariae (Nematoda: Filaroidea). Parasitology 65, 317-332.
15. PIESSENS, W. F. & BELDEKAS, M. (1979). Diethylcarbamazine enhances antibody-mediated cellular adherence to Brugia malayi microfilariae. Nature, London 282, 845-847.
16. SANTIAGO-STEVENSON, D., OLIVER GONZALEZ, J. & HEWITT, R. J. (1947). Treatment of filariasis bancrofti with 1-diethylcarbamyl-4-methylpiperazine hydrochloride (Hetrazan). Journal of the American Medical Association 135, 708-712.
17. SCHARDEIN, J. L., LUCAS, J. & DICKERSON, C.W. (1968). Ultrastructural changes in Litomosoides carinii microfilariae in gerbils treated with diethylcarbamazine. Journal of Parasitology 54, 351-358.
18. STEVENS, R. L., PARSONS, W. G., AUSTEN, K. F., HEIN, A. & CAULFIELD, J. P. (1985). Novel inhibition of proteoglycan synthesis and exocytosis by diethylcarbamazine in the swarm rat chondrocyte. Journal of Biological Chemistry 260, 5777-5786.
19. SUBRAHMANYAM, D. (1987). Antifilarials and their mode of action. In Filariasis, Ciba Symposium 127, 246-264.