Renal effects of BG9928, an A1 adenosine receptor antagonist, in rats and nonhuman primates

Drug Development Research

Volumn 58, Issue 4, 2003, Pages 486-492

  Ticho, Barry ^a   Whalley, Eric ^a   Gill, Alan ^a   Lutterodt, Frank ^a   Jin, Xiaowei ^a   Auchampach, John ^b   Smits, Glenn ^a  

^a BIOGEN   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Adenosine receptor; Adenosine receptor antagonist; Adentri; BG9928; Congestive heart failure; Glomerular filtration rate; Natriuresis

Indexed keywords

3 [4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)BICYCLO[2.2.2]OCTAN 1 YL]PROPIONIC ACID; 3 [4 (2,6 DIOXO 1,2 DIPROPYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL)BICYCLO[2.2.2]OCT 1 YL]PROPIONIC ACID; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENTRI; FUROSEMIDE; LOOP DIURETIC AGENT; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DIURETIC ACTIVITY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG RESPONSE; GLOMERULUS FILTRATION RATE; KIDNEY FAILURE; MONKEY; NONHUMAN; PRIMATE; RAT; RECEPTOR AFFINITY;

EID: 0038049149     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10176     Document Type: Conference Paper

References (10)

1. i) and the concentration of inhibitor which causes 50 percent inhibition (IC50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
2. 1-receptor antagonists in congestive heart failure. Drugs 61:1387-1393.
3. 1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation 105:1348-1353.
4. Krumholz HM, Chen YT, Vaccarino V, Wang Y, Radford MJ, Bradford WD, Horwitz RI. 2000. Correlates and impact on outcomes of worsening renal function in patients ≥65 years of age with heart failure. Am J Cardiol 85:1110-1113.
5. Mahon NG, Blackstone EH, Francis GS, Starling RC III, Young JB, Lauer MS. 2002. The prognostic value of estimated creatinine clearance alongside functional capacity in ambulatory patients with chronic congestive heart failure. J Am Coll Cardiol 40:1106-1113.
6. Maxwell PA, Ong HY, Nicholls DP. 2002. Influence of progressive renal dysfunction in chronic heart failure. Eur J Heart Failure 4:125-130.
7. Packer M. 1996. New concepts in the pathophysiology of heart failure: beneficial and deleterious interaction of endogenous haemodynamic and neurohormonal mechanisms. J Intern Med 239:327-333.
8. 1 receptor antagonists in the kidney: effects in fluid retaining disorders. Curr Opin Pharmacol 2:165-170.
9. 1 receptor antagonist. J Am Soc Nephrol 10:714-720.
10. 1 adenosine receptor antagonist, in congestive heart failure. Drug Dev Res 45:166-171.