Increase in neuronal nitric oxide synthase content of the gastroduodenal tract of diabetic rats

Cellular and Molecular Life Sciences

Volumn 60, Issue 6, 2003, Pages 1172-1179

  Adeghate, E ^a   Al Ramadi, B ^a   Saleh, A M ^a   Vijayarasathy, C ^a   Ponery, A S ^a   Arafat, K ^a   Howarth, F C ^a   El Sharkawy, T ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Diabetes mellitus; Gastroduodenum; Immunohistochemistry; Neural nitric oxide synthase; Rat; Western blot

Indexed keywords

NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DIABETES MELLITUS; DUODENUM; ENZYME ASSAY; MALE; MYENTERIC PLEXUS; NERVE CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; STAINING; STOMACH; STOMACH ANTRUM; STOMACH EMPTYING; STOMACH INNERVATION; TISSUE LEVEL; WESTERN BLOTTING;

ANIMALIA;

EID: 0038047900     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-003-2298-2     Document Type: Article

References (24)

1. Rodeberg D. A., Chaet M. S., Bass R. C., Arkovitz M. S. and Garcia V. F. (1995) Nitric oxide: an overview. Am. J. Surg. 170: 292-303.
2. Whittle B. J. (1997) Nitric oxide - a mediator of inflammation or mucosal defence. Eur. J. Gastroenterol. Hepatol. 9: 1026-1032.
3. Tomita R., Kurosu Y. and Munakata K (1997) Relationship between nitric oxide and non-adrenergic non-cholinergic inhibitory nerves in human lower esophageal sphincter. J. Gastroenterol. 32: 1-5.
4. Stebbing J. F. (1998) Nitric oxide synthase neurons and neuromuscular behavior of the anorectum. Ann. R. Coll. Surg. Engl. 80: 137-145.
5. Li Z. S., Murphy S., Furness J. B., Young H. M. and Campbell G. (1993) Relationship between nitric oxide synthase, vasoactive intestinal polypeptide and substance P immunoreactivities in neurons of the amphibian intestine. J. Auton. Nerv. Syst. 44: 197-206.
6. Adeghate E., Nádas G., Donáth T. and Parvez H. (1995) Identification of NADPH-diaphorase (nitric oxide synthase-positive neurons in the gastrointestinal tract of the rat. Biogenic Amines 11: 255-260.
7. Jarvinen M. K., Wollman W. J., Powrozek T. A., Schultz J. A. and Powley T. L. (1999) Nitric oxide synthase-containing neurons in the myenteric plexus of the rat gastrointestinal tract: distribution and regional density. Anat. Embryol. 199: 99-112.
8. Sann H., Hoppe S., Baldwin L., Grundy D. and Schemann, M. (1998) Presence of putative neurotransmitters in the myenteric plexus of the gastrointestinal tract and in the musculature of the urinary bladder of the ferret. Neurogastroenterol. Motil. 10: 35-47.
9. Furness J. B., Li Z. S., Young H. M. and Forstermann U. (1994) Nitric oxide synthase in the enteric nervous system of the guinea pig: a quantitative description. Cell Tissue Res. 277: 139-149.
10. Russo A., Fraser R., Adachi K., Horowitz M. and Boeckxstaens G. (1999) Evidence that nitric oxide mechanisms regulate small intestinal motility in humans. Gut 44: 72-76.
11. Brookes S. J. (1993) Neuronal nitric oxide in the gut. J. Gastroenterol. Hepatol. 8: 590-603.
12. Adeghate E. (1999) Effect of subcutaneous pancreatic tissue transplants on streptozotocin-induced diabetes in rats. II. Endocrine and metabolic functions. Tissue Cell 31: 73-83.
13. Zamboni L. and de Martino C. (1967) Buffered picric acid-formaldehyde: a new rapid fixation for electron microscopy. J. Cell Biol. 35: 148A.
14. Adeghate E., Seker M., Ponery A. S., Ahmed I., Pallot D. J. and Parvez H. (1996) Immunohistochemical localization of vimentin, S-100 protein and neurofilament in the lacrimal gland of the camel (Camelus dromedarius). Biogenic Amines 12: 437-444.
15. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227: 680-685.
16. Towbin I., Staehelin T. and Gordon J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76: 4350-4354.
17. al-Ramadi B. K., Al-Dhaheri M. A., Mustafa N., AbouHaidar M., Xu D., Liew F. Y. et al. (2001) Influence of vector-encoded cytokines on anti-Salmonella immunity: divergent effects of IL-2 and tumor necrosis factor alpha. Infect. Immun. 69: 3980-3988.
18. De Giorgio R., Parodi J. E., Brecha N. E., Brunicardi F. C., Becker J. M., Go V. L. et al. (1994) Nitric oxide producing neurons in the monkey and human digestive system. J. Comp. Neurol. 342: 619-627.
19. Wrzos H. F., Cruz A., Polavarapu R., Shearer D. and Ouyang A. (1997) Nitric oxide synthase (NOS) expression in the myenteric plexus of streptozotocin-diabetic rats. Dig. Dis. Sci. 42: 2106-2110
20. Singh J., Adeghate E., Salido G. M., Pariente J. A. and Juma L. M. O. (1999) Interaction between pancreatic hormones with cholecystokinin-octapeptide-evoked responses in the isolated pancreas of normal and diabetic rats. Exp. Physiol. 84: 299-318
21. Anggard E. (1994) Nitric oxide: mediator, murderer and medicine. Lancet 343: 1199-1206
22. Takahashi T., Nakamura K., Itoh H., Sima A. A. and Owyang C. (1997) Impaired expression of nitric oxide synthase in the gastric myenteric plexus of spontaneously diabetic rats. Gastroenterology 113: 1535-1544.
23. Watkins C. C., Sawa A., Jaffrey S., Blackshaw S., Barrow R. K., Snyder S. H. et al. (2000) Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy. J. Clin. Invest. 106: 373-384.
24. Adeghate E. and Parvez H. (2000) Nitric oxide and pancreatic and neuronal cell death. Toxicology 153: 145-158.