Control of crystal habit and size of cefmatilen hydrochloride hydrate with a habit modifier

Organic Process Research and Development

Volumn 7, Issue 3, 2003, Pages 334-338

  Masui, Yoshiyuki ^a   Kitaura, Yoji ^a   Kobayashi, Tatsuya ^a   Goto, Yoshihisa ^a   Ando, Satoru ^a   Okuyama, Akira ^a   Takahashi, Hisanori ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM CHLORIDE; CEFMATILEN; CELLULOSE DERIVATIVE; FUNCTIONAL GROUP; POLYVINYL DERIVATIVE;

ADDITION REACTION; ARTICLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; MOLECULAR SIZE; SUSPENSION; TEMPERATURE;

EID: 0038046330     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0256082     Document Type: Article

References (19)

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15. Viscosity of the gelatinous slurry during the agitation under the acidic condition (1 M to 3 M HCl) was variable not only between the runs but also in the same run. The thixotropic phenomenon depended upon the concentration of acid. When the concentration of HCl was ∼0.0001 M (pH 4), no phenomenon occurred. However, a higher concentration of HCl than 1 M was necessary for crystallization.
16. HPC is classified by the viscosity of its aqueous solution depending on its degree of polymerization. Viscosity of 2% aqueous solution at 20°C (CPS): HPC-L, 6-10; HPC-M, 150-400.
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19. 2O molecule and N1-position of triazolyl group is observed. The N3-position of the triazolyl group is used for intermolecular hydrogen bonding.