Total coenzyme Q10 concentrations in asian men following multiple oral 50-mg doses administered as coenzyme Q10 sustained release tablets or regular tablets

Biological and Pharmaceutical Bulletin

Volumn 26, Issue 1, 2003, Pages 52-55

  Lu, Wan Liang ^a,b,c   Zhang, Qiang ^a   Lee, How Sung ^b   Zhou, Tian Yan ^a   Sun, Hua Dong ^a   Zhang, Da Wei ^a   Zheng, Li ^a   Lee, Michael ^d   Wong, Sai Ming ^d  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^d AlphaRX Inc   (Canada)

Author keywords

Asian human healthy volunteer; Coenzyme Q10; HPLC UV; Plasma concentration; Sustained release tablets

Indexed keywords

UBIDECARENONE; DRUG DERIVATIVE; UBIQUINONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; ASIAN; COMPARATIVE STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EXPOSURE; GENDER; HEALTH STATUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; STANDARDIZATION; SUSTAINED RELEASE PREPARATION; TABLET; TIME; ULTRAVIOLET RADIATION; VOLUNTEER; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED RELEASE FORMULATION; GENETICS; RANDOMIZED CONTROLLED TRIAL;

ADULT; AREA UNDER CURVE; ASIAN CONTINENTAL ANCESTRY GROUP; DELAYED-ACTION PREPARATIONS; HUMANS; MALE; TABLETS; UBIQUINONE;

EID: 0038044626     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.26.52     Document Type: Article

References (10)

1. Ernster L., "Biomedical and Clinical Aspects of Coenzyme Q," Vol. 1, Amsterdam, Elsevier/North-Holland, 1977, p. 15.
2. Kaikkonen J., Nyyssonen K., Salonen J. T., Scand J Clin Lab. Invest , 59, 457-466 (1999).
3. Hodges S , Hertz N , Lockwood K., Lister R., Biofactors, 9, 365-370 (1999).
4. Greenberg S., Frishman W. H., J. Clin. Pharmacol., 30, 596-608 (1990)
5. Anderson S , J. Chromatogr A, 606, 272-276 (1992).
6. Grossi G , Bargossi A. M., Fiorella P. L , Piazzi S., Battino M., Bianchi G P., J Chromatogr A. 593, 217-226 (1992).
7. Kommuru T. R., Khan M. A., Ashraf M., Kattenacker R. and Reddy I K., J. Pharm. Biomed Anal , 16, 1037-1040 (1998).
8. Kaikkonen J., Nyyssonen K , Tuomamen T. P., Ristonmaa U , Salonen J. T , FEBS Lett , 443, 163-166 (1999).
9. Weis M., Mortensen S. A., Rassing M. R , Moller-Sonnergaard J., Poulsen G., Rasmussen S. N., Mol. Aspects Med , 15 (Suppl.), s273-s280 (1994)
10. Sustry P. S , Jayaraman J., Ramasama T , Nature (London), 189, 577 (1961)