Comparison between morphometry and immunostaining of malignant cells in non-small cell lung cancer

Analytical and Quantitative Cytology and Histology

Volumn 25, Issue 3, 2003, Pages 169-176

  Politi, Ekaterini N ^b   Lazaris, Andreas C ^a   Kavantzas, Nikolaos ^a   Koutselini, Helen ^b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b NONE

Author keywords

Immunochemistry; Lung cancer; Morphometry; Non small cell lung cancer

Indexed keywords

FAS LIGAND; KI 67 ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER SURVIVAL; CELL STRUCTURE; CLINICAL FEATURE; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; STATISTICAL ANALYSIS;

BIOMETRY; CARCINOMA, NON-SMALL-CELL LUNG; CELL NUCLEUS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 0038043486     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Sallinen P, Haapasalo H, Kerttula T, Rantala I, Kalimo H, Collan Y, Isola J, Helin H: Sources of variation in the assessment of cell proliferation using proliferating cell nuclear antigen immunohistochemistry. Analyt Quant Cytol Histol 1994;16:261-268
2. Stenback F, Makinen M, Jussila T: p53 Expression in skin carcinogenesis and its relationship to cell proliferation and tumour growth. Eur J Cancer 1998;34:1415-1424
3. Siitonen SM, Kallioniemi OP, Isola JJ: Proliferating cell nuclear antigen immunohistochemistry using monoclonal antibody 19A2 and a new antigen retrieval technique has prognostic impact in archival paraffin-embedded node-negative breast cancer. Am J Pathol 1993;142:1081-1089
4. Hofmann HS, Knolle J, Bahn H, Klapperstuck T, Lautenschlager C, Neef H: Flow cytometric analysis of DNA content and proliferation and immunohistochemical staining of Ki-67 in non-small cell lung cancer. J Cardiovasc Surg (Turin) 2001;42:555-560
5. Shiba MKK, Kohno H, Shibuya K, Yamakawa H, Hiroshima K, Fujisawa T: Prognostic implication of Ki-67 immunostaining in treating subclinical pleural cancer found at thoracotomy in lung cancer patients. Ann Thorac Surg 2001;71:1765-1771
6. Laitakari J, Harrison D, Stenback F: Morphometric characteristics of cell proliferation and p53 expression in development of experimentally induced respiratory tumors. Analyt Quant Cytol Histol 2001;23:273-286
7. Mandziuk S, Dudzisz-Sledz M, Rybacka-Chabros B, Zdunek M, Jakubowicz-Klecha A, Korobowicz E, Milanowski J, Wojcierowski J: Expression of p21 and bcl-2 proteins and p53 mRNA in surgically resected preparations of non-small cell lung cancer (stage IIIA) after etoposide and cisplatin chemotherapy. Folia Histochem Cytobiol (suppl) 2001;39: 175-176
8. Gessner C, Liebers U, Kuhn H, Stiehl P, Witt C, Schauer J, Wolff G: BAX and p16INK4A are independent positive prognostic markers for advanced tumour stage of nonsmall cell lung cancer. Eur Respir J 2002;19:134-140
9. Boldrini L, Faviana P, Gisfredi S, Di Quirico D, Lucchi M, Mussi A, Angeletti CA, Baldinotti F, Fogli A, Simi P, Basolo F, Pingitore F, Fontanini G: Identification of Fas (APO-1/CD95) and p53 gene mutations in non-small cell lung cancer. Int J Oncol 2002;20:155-159
10. Boldrini LFP, Pistolesi F, Gisfredi S, Di Quirico D, Lucchi M, Mussi A, Angeletti CA, Baldinotti F, Fogli A, Simi P, Basolo F, Fontanini G: Alterations of Fas (APO-1/CD 95) gene and its relationship with p53 in non small cell lung cancer. Oncogene 2001;4:6632-6637
11. Kitamura H, Kameda Y, Nakamura N, Inayama Y, Nakatani Y, Shibagaki T, Ito T, Hayashi H, Kimura H, Kanisawa M: Atypical adenomatous hyperplasia and bronchoalveolar lung carcinoma. Analysis by morphometry and the expressions of p53 and carcinoembryonic antigen. Am J Surg Pathol 1996;20:553-562
12. Ishikuro A, Dosaka-Akita H, Kato M, Fujino M, Isobe H, Miyamoto H, Inoue K, Kawakami Y: Ki-67 labeling indices in non-small cell lung cancer: Comparison between image cytometry and flow cytometry. Cytometry 1997;30:186-191
13. Dworakowska D, Gozdz S, Jassem E, Badzio A, Kobierska G, Urbaniak A, Skokowski J, Damps I, Jassem J: Prognostic relevance of proliferating cell nuclear antigen and p53 expression in non-small cell lung cancer. Lung Cancer 2002;35: 35-41
14. Querzoli P, Albonico G, Ferretti S, Rinaldi R, Magri E, Indelli M, Nenci I: MIB-1 proliferative activity in invasive breast cancer measured by image analysis. J Clin Pathol 1996;49: 926-930
15. Remmele W, Schicketanz KH: Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer: Computer-assisted image analysis (QIC score) vs. subjective grading (IRS). Pathol Res Pract 1993;189:862-866
16. Asamura H, Ando M, Matsuno Y, Shimosato Y: Histopathologic prognostic factors in resected adenocarcinomas: Is nuclear DNA content prognostic? Chest 1999;115:1018-1024
17. Cagle PT, Langston C, Fraire AE, Roggli VL, Greenberg SD: Absence of correlation between nuclear morphometry and survival in stage I non-small cell lung carcinoma. Cancer 1992;69:2454-2457
18. Carvalho PEAL, Bernardi FD, Leao LE, Rodrigues OR, Capelozzi VL: Useful prognostic panel markers to express the biological tumor status in resected lung adenocarcinomas. Jpn J Clin Oncol 2000;30:478-489
19. Kavantzas N, Lazaris AC, Chatzigianni E, Davaris PS: The nuclear morphometry by image analysis in the histopathologic diagnosis of lung cancer. J Exp Clin Cancer Res 2000; 19:201-206
20. Mori M, Chiba R, Takahashi T: Atypical adenomatous hyperplasia of the lung and its differentiation from adenocarcinoma: Characterization of atypical cells by morphometry and multivariate cluster analysis. Cancer 1993;72:2331-2340
21. American Joint Committee on Cancer: Lung. In AJCC Cancer Staging Manual. Sixth edition. New York, Springer, 2002, pp 167-181
22. Rosai J: Lung cancer. In Ackermann's Surgical Pathology. Eighth edition. First volume. Edited by G Stamathis. St Louis, Mosby, 1996, pp 289-434
23. Brahmi U, Rajwanshi A, Joshi K, Dey P, Vohra H, Ganguly NK, Gupta SK: Automated nuclear image morphometry on fine needle aspiration smears of malignant round cell tumors. Analyt Quant Cytol Histol 2001;23:287-290
24. Burns TR, Underwood RD, Greenberg SD, Teasdale TA, Cartwright J Jr: Cytomorphometry of large cell carcinoma of the lung. Analyt Quant Cytol Histol 1989;11:48-52
25. Burns TR, Teasdale TA, Greenberg SD: Use of morphometry as an aid in the differential diagnosis of large cell carcinoma of the lung. Analyt Quant Cytol Histol 1993;15:101-106
26. Marchevsky AM, Gal AA, Shah S, Koss MN: Morphometry confirms the presence of considerable nuclear size overlap between "small cells" and "large cells" in high-grade pulmonary neuroendocrine neoplasms. Am J Clin Pathol 2001; 116:466-472
27. Steels E, Paesmans M, Berghmans T, Branle F, Lemaitre F, Mascaux C, Meert AP, Vallot F, Lafitte JJ, Sculier JP: Role of p53 as a prognostic factor for survival in lung cancer: A systematic review of the literature with a meta-analysis. Eur Respir J 2001;18:705-719
28. Laudanski J, Niklinska W, Burzykowski T, Chyczewski L, Niklinski J: Prognostic significance of p53 and bcl-2 abnormalities in operable nonsmall cell lung cancer. Eur Respir J 2001;17:660-666
29. DeMay MR: Lung cancer. In The Art and Science of Cytopathology. Second volume. Edited by P Rogers. Chicago, ASCP Press, 1996, pp 960-962