In-vitro crystallization of indinavir in the presence of ritonavir and as a function of pH

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 5, 2003, Pages 707-711

  Li, Lilian Y ^a   Rodríguez Hornedo, Naír ^a   Heimbach, Tycho ^a   Fleisher, David ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDINAVIR; PROTEINASE INHIBITOR; RITONAVIR;

ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG IMPURITY; DRUG SOLUBILITY; IN VITRO STUDY; INTESTINE TRANSIT TIME; PH; PRECIPITATION; STOMACH EMPTYING;

CAPSULES; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DIETARY PROTEINS; FOOD-DRUG INTERACTIONS; HYDROGEN-ION CONCENTRATION; INDINAVIR; RITONAVIR;

EID: 0038043142     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235703765344630     Document Type: Article

References (8)

1. Balani, S. K., Arison, B. H., Mathai, L., Kauffman, L. R., Miller, R. R., Stearns, R. A., Chen, I. W., Lin J. H. (1995) Metabolites of L-735,524, a potent HIV-1 protease inhibitor, in human urine. Drug Metab. Dispos. 23: 266-270
2. Balani, S. K., Woolf, E. J., Hoagland, V. L., Sturgill, M. G., Deutsch, P. J., Yeh, K. C., Lin, J. H. (1996) Disposition of indinavir, a potent HIV-1 protease inhibitor, after an oral dose in humans. Drug Metab. Dispos. 24: 1389-1394
3. Carver, P. L., Fleisher, D., Zhou, S. Y., Kaul, D., Kazanjian, P., Li, C. (1999) Meal composition effects on the oral bioavailability of indinavir in HIV-infected patients. Pharm. Res. 16: 718-724
4. Daudon, M, Estepa, L., Viard, J. P., Joly, D., Jungers, P. (1997) Urinary stones in HIV-1-positive patients treated with indinavir. Lancet 349: 1294-1295
5. Gagnon, R. F., Tsoukas, C. M., Watters, A. K. (1998) Light microscopy of indinavir urinary crystals. Ann. Intern. Med. 128: 321
6. Gagnon, R. F., Tecimer, S. N., Watters, A. K., Tsoukas, C. M. (2000) Prospective study of urinalysis abnormalities in HIV-positive individuals treated with indinavir. Am. J. Kidney Dis. 36: 507-515
7. Li, L. Y., Stewart, B. H., Fleisher, D. (2000) Oral delivery of HIV-protease inhibitors. Crit. Rev. Ther. Drug Carrier Syst. 17: 73-99.
8. Rajs, J., Blaxhult, A., Sundelin, B. (2000) Sudden unexpected death as a consequence of indinavir-induced nephropathy. A case report. APMIS 108: 581-583