Sample power and ExpDesign: Tools for improving design of animal experiments

Lab Animal

Volumn 32, Issue 3, 2003, Pages 39-43

  Van Wilgenburg, Henk ^a   Van Schaick Zillesen, Piet G ^b   Krulichova, Iva ^c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b VAN HALL LARENSTEIN UNIVERSITY OF APPLIED SCIENCES   (Netherlands)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PETHIDINE; PHENYLBUTAZONE; SODIUM CHLORIDE; ANALGESIC AGENT;

ACCURACY; ANALGESIC ACTIVITY; ANALYTIC METHOD; ANIMAL TESTING REDUCTION; ANIMAL TESTING REFINEMENT; ANIMAL WELFARE; ARTICLE; CALCULATION; COMPUTER ANALYSIS; COMPUTER PROGRAM; COMPUTER SIMULATION; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; EXPERIMENTAL DESIGN; EXPERIMENTAL MODEL; INFORMATION PROCESSING; LEARNING; MATHEMATICAL ANALYSIS; MAXIMUM ALLOWABLE CONCENTRATION; METHODOLOGY; NONHUMAN; PRACTICE GUIDELINE; QUALITATIVE ANALYSIS; QUALITY CONTROL; RESPONSE TIME; SAMPLE; SAMPLE SIZE; SKILL; STATISTICAL ANALYSIS; STUDENT; UNIVERSITY; ANIMAL; HEAT; MOUSE; PAIN; REVIEW; STATISTICS; TEACHING;

ANIMALIA;

ANALGESICS; ANIMAL WELFARE; ANIMALS; COMPUTER-ASSISTED INSTRUCTION; DRUG EVALUATION, PRECLINICAL; HEAT; MEPERIDINE; MICE; PAIN; RESEARCH DESIGN; SAMPLE SIZE;

EID: 0038041982     PISSN: 00937355     EISSN: None     Source Type: Journal    
DOI: 10.1038/laban0303-39     Document Type: Article

References (17)

1. Festing, M.F.W. in World Congress on Alternatives and Animal Use in the Life Sciences: Education, Research, Testing (eds. Goldberg A.M. & van Zutphen L.F.M.) 43-49 (Mary Ann Liebert, Inc., Larchmont, NY, 1995).
2. Russell, W.M.S. & Burch, R.L. The Principles of Humane Experimental Technique (Methuen and Co Ltd., London, 1959).
3. Fisher, R.A. The Design of Experiments (Oliver & Boyd, Edinburgh, 1935).
4. Clarke, G.M. & Kempson, R.E. Introduction to the Design and Analysis of Experiments (Arnold, London, 1997).
5. Cox, D.R. Planning Experiments (John Wiley & Sons, New York, NY, 1958).
6. Mead, R. The Design of Experiments: Statistical Principles for Practical Applications (Cambridge University Press, Cambridge, 1988).
7. Montgomery, D.C. Design and Analysis of Experiments 4th edn. (John Wiley & Sons, New York, NY, 1997).
8. Chapman, P.F., Crane, M., Wile, J.A., Noppert, F. & McIndoe, E.C. Asking the Right Questions: Ecotoxicology and Statistics (Workshop report. SETAC Europe, Brussels, 1996).
9. Prentice, R.L. & Gloeckler, L.A. Regression analysis of grouped survival data with application to breast cancer data. Biometrics 34, 57-67 (1978).
10. Festing, M.F. Reduction of animal use: experimental design and quality of experiments. Lab. Anim. 28, 212-221 (1994).
11. Murray, K.A. Issues to consider when phenotyping mutant mouse models. Lab. Anim. 31, 25-29 (2002).
12. Shaw, R., Festing, M.F.W., Peers, I. & Furlong L. Use of factorial designs to optimize animal experiments and reduce animal use. ILAR J. 43, 223-232 (2002).
13. Van Wilgenburg, H. in World Congress on Alternatives and Animal Use in the Life Sciences: Education, Research, Testing (eds. Goldberg, A.M. & van Zutphen, L.F.M.) 559-565 (Mary Ann Liebert, Inc., Larchmont, NY, 1995).
14. Festing, M.F.W. in Progress in the Reduction, Refinement and Replacement of Animal Experimentation (eds. Balls, M., van Zeiler, A-M. & Halder M.) 753-758 (Elsevier, Amsterdam, 2000).
15. Festing, M.F.W. in Statistics in Toxicology (ed. Morgan, B.J.T.) 3-11 (Clarendon Press, Oxford, 1996).
16. Finney, D.J. Probit Analysis 3rd edn. (Cambridge University Press, Cambridge, 1991).
17. Van Wilgenburg, H. in Animal Alternatives, Welfare and Ethic (eds. Van Zutphen, L.F.M. & Balls M.) 467-476 (Elsevier, Amsterdam, 1997).