Neurotoxicity following addition of intravenous valproate to lamotrigine therapy

Neurology

Volumn 60, Issue 12, 2003, Pages 1991-1992

  Burneo, J G ^a   Limdi, N ^a   Kuzniecky, R I ^a   Knowlton, R C ^a   Mendez, M ^a   Lawn, N ^b   Faught, E ^a   Welty, T E ^b   Prasad, A ^a  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^b SAMFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; CARBAMAZEPINE; CLONAZEPAM; LAMOTRIGINE; LORAZEPAM; TOPIRAMATE; VALPROIC ACID;

ABSENCE; ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; CONFUSION; DISORIENTATION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG RESPONSE; ELECTROENCEPHALOGRAPHY; EPILEPTIC STATE; FEMALE; HUMAN; LETHARGY; NEUROTOXICITY; PRIORITY JOURNAL; SYMPTOM;

EID: 0038038031     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000065915.68602.91     Document Type: Article

References (8)

1. Karceski S, Morrell M, Carpentar D. The expert consensus guideline series: treatment of epilepsy. Epilepsy Behav 2000;2:A1-A50.
2. Mayer SA. Controversies in critical care: treatment options for refractory status epilepticus. Presented at the 52nd Annual Meeting of the American Academy of Neurology, San Diego, CA, 2000:39-43.
3. Genton P, Gelisse P. Valproic acid: adverse effects. In: Levy RH, Mattson RH, Meldrum BS, Perucca E, eds. Antiepileptic drugs. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2002:837-851.
4. Kanner AM, Frey M. Adding valproate to lamotrigine: a study of their pharmacokinetic interaction. Neurology 2000;55:588-591.
5. Yuen AW, Land G, Weatherley BC, Peak AW. Sodium valproate acutely inhibits lamotrigine metabolism. Br J Clin Pharmacol 1992;33:511-513.
6. Decerce J, McJilton JS, Nadkarni M, Ramsay RE. Lamotrigine-valproate interaction: relationship to the dose of valproate. Epilepsia 2000; 41(suppl 7):220-221.
7. Ramsey RE, Uthman B, Leppik IE, et al. The tolerability and safety of valproate injection given as an intravenous infusion. J Epilepsy 1997;10:187-193.
8. Venkatraman V, Wheless JW. Safety of rapid intravenous infusion of valproate loading doses in epilepsy patients. Epilepsy Res 1999;35:147-153.