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Volumn 42, Issue 25, 2003, Pages 2853-2857

Gold-cluster degradation by the transition of B-DNA into A-DNA and the formation of nanowires

Author keywords

Antitumor agents; DNA structures; Electron microscopy; Gold; Metal DNA interactions

Indexed keywords

DEGRADATION; DEHYDRATION; ELECTRON MICROSCOPY; GOLD; NANOSTRUCTURED MATERIALS;

EID: 0038034791     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200250235     Document Type: Article
Times cited : (97)

References (35)
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    • note
    • The samples for AFM measurement were prepared in solution by mixing DNA and cluster. A drop of solution was then placed onto a mica surface and dried in air. The measurements were performed with a Nanoscope IIIA, Multi Mode in the tapping mode.
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    • note
    • The crystal structures of dodecameric A-DNA and B-DNA were obtained from the Protein Data Bank (PDP). Two copies of each crystal structure were joined by phosphodiester bonds to form a 24-A-DNA and 24-B-DNA molecules, respectively. Both conformations of DNA in the presence and absence of gold clusters were energy minimized using the Conjugate Gradient Polak-Ribiere method. Minimization was performed to obtain configurations with the lowest possible energy before performing any molecular-dynamic simulations. The atom types and partial charges were assigned according to the PCFF force field. The PCFF force field is a second-generation force field which is appropriate for simulations performed on nucleic acids, carbohydrates, and lipids, and contains interaction parameters for many metals including Au.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.