Low hepatotoxicity and lack of pneumotoxicity of the styrene metabolites 1-phenylethanol, 2-phenylethanol and phenylacetaldehdye in mice

Research Communications in Pharmacology and Toxicology

Volumn 7, Issue 1-2, 2002, Pages 45-52

  Carlson, Gary P ^a   Mantick, Nancy A ^a   Ramseyer, Kathleen S ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

4 vinylphenol; Bronchoalveolar fluid; Hepatotoxicity; Lactate dehydrogenase; Phenylacetaldehyde; Phenylethanols; Pneumotoxicity; Sorbitol dehydrogenase; Styrene metabolism; Styrene oxide

Indexed keywords

1 PHENYLETHANOL; 4 VINYLPHENOL; ACETALDEHYDE; IDITOL DEHYDROGENASE; PHENETHYL ALCOHOL; PHENYLACETALDEHYDE; STYRENE DERIVATIVE; STYRENE OXIDE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; LIVER TOXICITY; LUNG LAVAGE; LUNG TOXICITY; MALE; MOUSE; NONHUMAN; XENOBIOTIC METABOLISM;

ANIMALIA;

EID: 0038021375     PISSN: 10871101     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Bakke, O.M. and Scheline, R.R. (1970). Hydroxylation of aromatic hydrocarbons in the rat. Toxicol. Appl. Pharmacol. 16: 691-700.
2. Bond, J.A. (1989). Review of the toxicology of styrene. Critical Rev. Toxicol. 19: 227-249.
3. Carlson, G.P., Ullman, M., Mantick, N.A. and Snyder, P.W. 2002 4-Vinylphenol-induced pneumotoxicity and hepatotoxicity in mice. Toxicologic Pathol. In press.
4. Cruzan, G., Cushman, J.R., Andrews, L.S., Granville, G.C., Miller, R.R., Hardy, C.J., Coombs, D.W. and Mullins, P.A. (1997). Subchronic inhalation studies of styrene in CD rats and CD-1 mice. Fundam. Appl. Toxicol. 35: 152-165.
5. Gadberry, M.G., DeNicola, D.B. and Carlson, G.P. (1996). Pneumotoxicity and hepatotoxicity of styrene and styrene oxide. J. Toxicol. Environ. Health 48: 273-294.
6. Gerlach, U. (1983). Sorbitol dehydrogenase. In Methods of Enzymatic Analysis, HU Bergmeyer (ed), 3 rd. ed., Verlag Chemie,Weinheim, pp. 112-117.
7. 13C8-styrene vapors. Toxicol. Appl. Pharmacol. 168: 36-49.
8. Landseidel, R., Kaufman, W., Mellert, W., and Hoffman, H.D. (2002) Tumor formation in mice by styrene: induction of cell proliferation in the lung by styrene metabolites. Toxicological Sci. 66 (1-S), 295.
9. Morgan, D.L., Mahler, J.F., Dill, J.A., Price, H.C., O'Connor, R.W. and Adkins, B. (1993a). Styrene inhalation toxicity studies in mice. III. Strain differences in susceptibility. Fundam. Appl. Toxicol. 21: 326-333.
10. Morgan, D.L., Mahler, J.F., O'Connor, R.W., Price, H.C. and Adkins, B. (1993b). Styrene inhalation toxicity studies in mice. I. Hepatotoxicity in B6C3F1 mice. Fundam. Appl. Toxicol. 20: 325-335.
11. 1 mice. National Toxicology Report TR 369. National Toxicology Program, Research Triangle Park, NC.
12. Pfaffli, P., Hesso, A., Vainio, H. and Hyvonen, M. (1981). 4-Vinylphenol excretion suggestive of arene oxide formation in workers occupationally exposed to styrene. Toxicol. Appl. Pharmacol. 60: 85-90.
13. Registry of Toxic Effects of Chemical Substances (RTECS) (1983). National Institutes for Occupational Safety and Health, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services.
14. Redinbaugh, M.G. and Turley, R.B. (1986). Adaptation of the bicinchoninic acid protein assay for use with microtiter plates and sucrose gradient fractions. Anal. Biochem. 153: 267-271.
15. Sumner, S. J. and Fennell, T.R. (1994). Review of the metabolic fate of styrene. Crit. Rev. Toxicol. 24(S1): S11-S33.
16. Vassault, A. (1983). Lactate dehydrogenase. UV method with pyruvate and NADH. In Methods of Enzymatic Analysis, HU Bergmeyer (ed), 3 rd. ed., Verlag Chemie, Weinheim, pp. 118-125.