Combination therapy with intraventricular interferon-α and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay

Brain and Development

Volumn 25, Issue 5, 2003, Pages 367-369

  Hara, Shinya ^a   Kimura, Hiroshi ^a   Hoshino, Yo ^a   Hayashi, Naomi ^a   Negoro, Tamiko ^a   Okumura, Akihisa ^a   Kajita, Yasuichi ^a   Sakuma, Takashi ^b   Nakayama, Tetsuo ^c   Hosoya, Mitsuaki ^d   Tomoda, Akemi ^e   Morisima, Tsuneo ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Sakuma Clinic   (Japan)

^c KITASATO INSTITUTE   (Japan)

^d FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^e KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Interferon ; Measles virus; Real time polymerase chain reaction assay; Ribavirin; Subacute sclerosing panencephalitis

Indexed keywords

ALPHA INTERFERON; INOSINE DERIVATIVE; MEASLES ANTIBODY; RIBAVIRIN; VIRUS RNA;

ANTIBODY TITER; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID EXAMINATION; CLINICAL FEATURE; DETERIORATION; DISEASE COURSE; DROP ATTACK; DRUG ADMINISTRATION ROUTE; DRUG EFFICACY; EDEMA; FAMILY HISTORY; HOSPITAL ADMISSION; HUMAN; LABORATORY TEST; LIP SWELLING; MALE; MEASLES VIRUS; MONITORING; NEUROLOGIC DISEASE; ONSET AGE; POLYMERASE CHAIN REACTION; PSYCHOMOTOR DEVELOPMENT; QUANTITATIVE ANALYSIS; RNA ANALYSIS; SCHOOL CHILD; SIDE EFFECT; SUBACUTE SCLEROSING PANENCEPHALITIS; SYMPTOMATOLOGY; TREATMENT OUTCOME; VIRUS LOAD; WHEELCHAIR;

EID: 0038016466     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0387-7604(03)00017-2     Document Type: Article

References (12)

1. Jones C.E., Dyken P.R., Huttenlocher P.R., Jabbour J.T., Maxwell K.W. Inosiplex therapy in subacute sclerosing panencephalitis: a multicentre, non-randomised study in 98 patients. Lancet. 1:1982;1034-1037.
2. Yalaz K., Anlar B., Oktem F., Aysun S., Ustacelebi S., Gurcay O., Gucuyener K., Renda Y. Intraventricular interferon and oral inosiplex in the treatment of subacute sclerosing panencephalitis. Neurology. 42:1992;488-491.
3. Tatter S.B., Carlos R.A., O'Donovan C.A. Intraparenchymal alpha interferon and intraventricular ribavirin for subacute sclerosing panencephlitis (SSPE). Neurology. 54:2000;A430.
4. Tomoda A., Shiraishi S., Hosoya M., Hamada A., Miike T. Combined treatment with interferon-alpha and ribavirin for subacute sclerosing panencephalitis. Pediatr. Neurol. 24:2001;54-59.
5. Dyken P.R., Swift A., DuRant R.H. Long-term follow-up of patients with subacute sclerosing panencephalitis treated with inosiplex. Ann. Neurol. 11:1982;359-364.
6. Jabbour J.T., Duenas D.A., Modlin J. SSPE; clinical staging, course and frequency. Arch. Neurol. 32:1975;493-494.
7. Nakayama T., Mori T., Yamaguchi S., Sonoda S., Asamura S., Yamashita R., Takeuchi Y., Urano T. Detection of measles virus genome directly from clinical samples by reverse transcriptase-polymerase chain reaction and genetic variability. Virus Res. 35:1995;1-16.
8. Anlar B., Yalaz K., Oktem F., Kose G. Long-term follow-up of patients with subacute sclerosing panencephalitis treated with intraventricular alpha-interferon. Neurology. 48:1997;526-528.
9. Kimura H., Morita M., Yabuta Y., Kuzushima K., Kato K., Kojima S., Matsuyama T., Morishima T. Quantitative analysis of Epstein-Barr virus load by using a real-time PCR assay. J. Clin. Microbiol. 37:1999;132-136.
10. Hosoya M., Shigeta S., Nakamura K., DeClercq E. Inhibitory effect of selected antiviral compounds on measles (SSPE) virus replication in vitro. Antiviral Res. 12:1989;87-97.
11. Takahashi T., Hosoya M., Kimura K., Ohno K., Mori S., Takahashi K., Shigeta S. The cooperative effect of interferon-alpha and ribavirin on subacute sclerosing panencephalitis (SSPE) virus infections, in vitro and in vivo. Antiviral Res. 37:1998;29-35.
12. Ishii T., Hosoya M., Mori S., Shigeta S., Suzuki H. Effective ribavirin concentration in hamster brains for antiviral chemotherapy for subacute sclerosing panencephalitis. Antimicrob. Agents Chemother. 40:1996;241-243.