A populationwide coalescent analysis of Icelandic matrilineal and patrilineal genealogies: Evidence for a faster evolutionary rate of mtDNA lineages than Y chromosomes

American Journal of Human Genetics

Volumn 72, Issue 6, 2003, Pages 1370-1388

  Helgason, Agnar ^a,b   Hrafnkelsson, Birgir ^a   Gulcher, Jeffrey R ^a   Ward, Ryk ^b   Stefánsson, Kári ^a  

^a DECODE GENETICS   (Iceland)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ALLELE; ARTICLE; DEMOGRAPHY; DNA DETERMINATION; EVOLUTION; FEMALE; GENEALOGY; GENETIC DATABASE; GEOGRAPHIC DISTRIBUTION; HAPLOTYPE; HUMAN; ICELAND; MALE; POPULATION GENETICS; PRIORITY JOURNAL; STOCHASTIC MODEL; Y CHROMOSOME;

MARTES PENNANTI;

EID: 0038015674     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/375453     Document Type: Article

References (33)

1. Austerlitz F, Heyer E (1998) Social transmission of reproductive behavior increases frequency of inherited disorders in a young-expanding population. Proc Natl Acad Sci USA 95: 15140-15144
2. Avise JC (2000) Phylogeography: the history and formation of species. Harvard University Press, Cambridge, MA
3. Barkardóttir RB, Sarantaus L, Arason A, Vehmanen P, Bendahl PO, Kainu T, Syrjakoski K, Krahe R, Huusko P, Pyrhonen S, Holli K, Kallioniemi OP, Egilson V, Kere J, Nevanlinna H (2001) Haplotype analysis in Icelandic and Finnish BRCA2 999del5 breast cancer families. Eur J Hum Genet 9:773-779
4. Brinkmann B, Klintschar M, Neuhuber F, Huhne J, Rolf B (1998) Mutation rate in human microsatellites: influence of the structure and length of the tandem repeat. Am J Hum Genet 62:1408-1415
5. Cavalli-Sforza LL, Bodmer WF (1971) The genetics of human populations. W. H. Freeman, San Francisco
6. Charlesworth B (2001) The effect of life-history and mode of inheritance on neutral genetic variability. Genet Res 77: 153-166
7. Crow JF, Kimura M (1970) An introduction to population genetics theory. Harper & Row, New York
8. Donnelly P, Marjoram P (1989) The effect on genetic sampling distributions of correlations in reproduction. Theor Popul Biol 35:22-35
9. Guomundsson H, Guobjartsson DF, Frigge M, Gulcher JR, Stefánsson K (2000) Inheritance of human longevity in Iceland. Eur J Hum Genet 8:743-749
10. Gulcher J, Stefánsson K (1998) Population genomics: laying the groundwork for genetic disease modeling and targeting. Clin Chem Lab Med 36:523-527
11. Guldberg P, Zschocke J, Dagbjartsson A, Henriksen KF, Guttler F (1997) A molecular survey of phenylketonuria in Iceland: identification of a founding mutation and evidence of predominant Norse settlement. Eur J Hum Genet 5:376-381
12. Helgason A (2001) The ancestry and genetic history of the Icelanders: an analysis of mtDNA sequences, Y-chromosome haplotypes and genealogies. DPhil thesis, University of Oxford, Oxford
13. Helgason A, Hickey E, Goodacre S, Bosnes V, Stefansson K, Ward R, Sykes B (2001) mtDNA and the islands of the North Atlantic: estimating the proportions of Norse and Gaelic ancestry. Am J Hum Genet 68:723-737
14. Helgason A, Siguroardóttir S, Gulcher JR, Ward R, Stefánsson K (2000a) mtDNA and the origin of the Icelanders: deciphering signals of recent population history. Am J Hum Genet 66:999-1016
15. Helgason A, Siguroardóttir S, Nicholson J, Sykes B, Hill EW, Bradley DG, Bosnes V, Gulcher JR, Ward R, Stefánsson K (2000b) Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland. Am J Hum Genet 67:697-717
16. Heyer E (1995) Mitochondrial and nuclear genetic contribution of female founders to a contemporary population in Northeast Quebec. Am J Hum Genet 56:1450-1455
17. Howell N (2000) Demography of the Dobe !Kung, 2nd ed. Aldine de Gruyter, New York
18. Hudson RR (1990) Gene genealogies and the coalescent process. In: Futuyma D, Antonovics J (eds) Oxford surveys in evolutionary biology. Vol 7. Oxford University Press, Oxford, pp 1-44
19. Ingman M, Kaessmann H, Paabo S, Gyllensten U (2000) Mitochondrial genome variation and the origin of modern humans. Nature 408:708-713
20. Jónsson G, Magnússon MS (1997) Hagskinna: Icelandic historical statistics. Hagstofa Íslands, Reykjavík
21. Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, Shlien A, Palsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefansson K (2002) A high-resolution recombination map of the human genome. Nat Genet 31:241-247
22. Murdock GP, White D (1969) Standard cross-cultural sample. Ethnology 8:329-369
23. Nei M, Murata M (1966) Effective population size when fertility is inherited. Genet Res 8:257-260
24. Nordborg M (2001) Coalescent theory. In: Balding DJ, Bishop M, Cannings C (eds) Handbook of statistical genetics. John Wiley and Sons, Chichester, pp 179-212
25. O'Brien E, Kerber RA, Jorde LB, Rogers AR (1994) Founder effect - assessment of variation in genetic contributions among founders. Hum Biol 66:185-204
26. Pfeiffer H, Brinkmann B, Huhne J, Rolf B, Morris AA, Steighner R, Holland MM, Forster P (1999) Expanding the forensic German mitochondrial DNA control region database: genetic diversity as a function of sample size and microgeography. Int J Legal Med 112:291-298
27. Roberts DF, Bear JC (1980) Measures of genetic change in an evolving population. Hum Biol 52:773-786
28. Seielstad MT, Minch E, Cavalli-Sforza LL (1998) Genetic evidence for a higher female migration rate in humans. Nat Genet 20:278-280
29. Siguroardóttir S, Helgason A, Gulcher JR, Stefánsson K, Donnelly P (2000) The mutation rate in the human mtDNA control region. Am J Hum Genet 66:1599-609
30. Skolnick M, Cavalli-Sforza LL, Moroni A, Siri E (1976) A preliminary analysis of the genealogy of Parma Valley, Italy. In: Ward R, Weiss K (eds) The demographic evolution of human populations. Academic Press, London
31. Thomson R, Pritchard JK, Shen P, Oefner PJ, Feldman MW (2000) Recent common ancestry of human Y chromosomes: evidence from DNA sequence data. Proc Natl Acad Sci USA 97:7360-7365
32. Tremblay M, Vézina H (2000) New estimates of intergenerational time intervals for the calculation of age and origins of mutations. Am J Hum Genet 66:651-658
33. Yu A, Zhao C, Fan Y, Jang W, Mungall AJ, Deloukas P, Olsen A, Doggett NA, Ghebranious N, Broman KW, Weber JL (2001) Comparison of human genetic and sequence-based physical maps. Nature 409:951-953