Making medicines that children can take

Archives of Disease in Childhood

Volumn 88, Issue 5, 2003, Pages 369-371

  Nunn, A J ^a  

^a ALDER HEY CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARGININE; BENZOIC ACID; CAFFEINE CITRATE; CAPTOPRIL; CHLORAL HYDRATE; FOLIC ACID; LABETALOL; MIDAZOLAM; NIFEDIPINE; ORPHAN DRUG; PROSTAGLANDIN E2; SILDENAFIL;

CAPSULE FILLING; CHILD HEALTH CARE; CHILDHOOD; DISPERSION; DRUG CAPSULE; DRUG DISPOSITION; DRUG DOSAGE FORM; DRUG MANUFACTURE; DRUG SAFETY; DRUG STABILITY; DRUG USE; EDITORIAL; GENERAL PRACTICE; HEALTH SURVEY; HOSPITAL PHARMACY; HUMAN; LICENCE; MEDICAL PRACTICE; PEDIATRICIAN; PH; PHARMACIST; PRESCRIPTION; PRIORITY JOURNAL; QUALITY CONTROL; SYRUP; TABLET;

CHILD; DOSAGE FORMS; DRUG COMPOUNDING; DRUG STABILITY; EUROPE; GREAT BRITAIN; HUMANS; LEGISLATION, PHARMACY; LICENSURE; PHARMACEUTICAL PREPARATIONS; RARE DISEASES; RISK FACTORS;

EID: 0037995618     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.88.5.369     Document Type: Editorial

References (26)

1. DOH/ABPI. www.doh.gov.uk/discontinuedmedicines/index.htm.
2. McIntyre J, Conroy S, Avery A, et al. Unlicensed and off label prescribing of drugs in general practice. Arch Dis Child 1999;83:498-501.
3. Turner S, Nunn AJ, Fielding K, et al. Adverse drug reactions to unlicensed and off-label drugs on paediatric wards: a prospective study. Acta Paediatr 1999;88:965-8.
4. Turner S, Longworth A, Nunn AJ, et al. Unlicensed and off label drug use in paediatric wards: prospective study. BMJ 1998;316:343-5.
5. Turner S, Gill A, Nunn AJ, et al. Use of "off label" and unlicensed drugs in a paediatric intensive care unit. Lancet 1996;347:549-50.
6. Conroy S, McIntyre J, Choonara I. Unlicensed and off label drug use in neonates. Arch Dis Child Fetal Neonatal Ed 1999;80:F142-4.
7. Seyberth HW. Aktuelle probleme der klinischen pharmacologie im kindesalter. Kinderarzt 1984;15:309-14.
8. Chalumeau M, Tréluyer JM, Salanave B, et al. Off label and unlicensed drug use among French office based paediatricians. Arch Dis Child 1999;83:502-5.
9. Conroy S, Choonara I, Impicciatore P, et al. Survey of unlicensed and off label drug use in paediatric wards in European countries. BMJ 2000;320:79-82.
10. 't Jong GW, Vulto AG, de Hoog M, et al. Unapproved and off-label use of drugs in a children's hospital. N Engl J Med 2000;343:1125.
11. 't Jong GW, Vulto AG, de Hoog M, et al. A survey of the use of off-label and unlicensed drugs in a Dutch children's hospital. Pediatrics 2001;108:1089-93.
12. Bücheler R, Schwab M, Mörike K, et al. Off label prescribing to children in primary care in Germany: retrospective cohort study. BMJ 2002;324:1311-12.
13. Schirm E, Tobi H, de Jong-van den Berg LTW. Unlicensed and off-label drug use by children in the community: cross sectional study. BMJ 2002;324:1312-13.
14. 't Jong GW, Eland IA, Sturkenboom MCJM, et al. Unlicensed and off-label prescription of drugs to children: population based cohort study. BMJ 2002;324:1313-14.
15. Royal College of Paediatrics and Child Health, and Neonatal and Paediatric Pharmacists Group. www.rcpch.ac.uk/publications/formulary_medicines/Unlicensed_Medic ines.pdf.
16. Royal College of Paediatrics and Child Health, and Neonatal and Paediatric Pharmacists Group. Medicines for children. London: RCPCH Publications Ltd on behalf of the RCPCH and NPPG, 1999.
17. Sedrati M, Arnaud P, Fontan J-E, et al. Splitting tablets in half. American Journal of Healthcare Pharmacy 1994;13:205-6.
18. Horn LW, Kuhn RJ, Kanga JF. Evaluation of the reproducibility of tablet splitting to provide accurate doses for the pediatric population. J Pediatr Pharm Practice 1999;4:38-42.
19. Woods DJ. Extemporaneous formulations-problems and solutions. In: Choonara I, Nunn AJ, eds. Paediatric and perinatal drug therapy. Liverpool, UK: Royal Liverpool Children's NHS Trust, 1997.
20. Boseley S. EU loophole sends drug prices soaring. Guardian 24 June 2002.
21. Medicines Control Agency. Rules and guidance for pharmaceutical manufacturers and distributors 1997. London: HMSO, 1997.
22. Anonymous. Boots pharmacist and trainee cleared of baby's manslaughter, but fined for dispensing a defective medicine. Pharm J 2000;264:390-2.
23. Royal College of Paediatrics and Child Health and Neonatal and Paediatric Pharmacists Group. www.rcpch.ac.uk/publications/formulary_medicines.
24. European Commission. http://pharmacos.eudra.org/F2/pharmacos/docs/ Doc2002/feb/cd_pediatrics_en.pdf.
25. Anonymous. France assesses paediatric needs. SCRIP No 2738, 17 April, 2002:7.
26. Shirkey H. Therapeutic orphans. J Pediatr 1968;72:119-20.