Elimination kinetics of chlorhexidine in milk following intramammary infusion to stop lactation in mastitic mammary gland quarters of cows

Journal of the American Veterinary Medical Association

Volumn 222, Issue 12, 2003, Pages 1746-1749

  Middleton, John R ^a   Hebert, Vincent R ^b   Fox, Lawrence K ^c   Tomaszewska, Elizabeth ^b   Lakritz, Jeff ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE;

ADOLESCENT; ARTICLE; COW; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; INTRAMAMMARY DRUG ADMINISTRATION; LACTATION; MASTITIS; MILK; NONHUMAN; PRACTICE GUIDELINE; PROSPECTIVE STUDY;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CATTLE; CHLORHEXIDINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG RESIDUES; FEMALE; LACTATION; MASTITIS, BOVINE; MILK; PROSPECTIVE STUDIES;

ANIMALIA;

EID: 0037977140     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.2003.222.1746     Document Type: Article

References (6)

1. Boddie RL, Nickerson SC. Permanent drying off of chronic mastitic quarters. Louisiana Cattlemen 1993;Nov:10-11.
2. Middleton JR, Fox L.K. Therapeutic cessation of lactation of Staphylococcus aureus infected mammary quarters. J Dairy Sci 2001; 84:1976-1978.
3. Tyler JW, Cullor JS, Erskine RJ, et al. Milk antimicrobial drug residue assay results in cattle with experimental, endotoxin-induced mastitis. J Am Vet Med Assoc 1992;201:1378-1384.
4. Hebert VR, Middleton JR, Tomaszewska E, et al. Methodology for quantifying residues of chlorhexidine in raw dairy milk. J Agric Food Chem 2003;51:567-570.
5. United States Environmental Protection Agency. R.E.D. Facts. Reregistration Eligibility Decision, EPA-738-F-96-025. 1996; 1-5.
6. United States Food and Drug Administration. Tolerances for residues of new animal drugs in food: chlorhexidine. Title 21 Code of Federal Regulations. Washington, DC: Office of the Federal Register National Archives and Records Administration, 2002;556: 120.