Of four murine, anti-Shigella dysenteriae type 1 O-polysaccharide antibodies, three employ V-genes that differ extensively from those of the fourth

Molecular Immunology

Volumn 33, Issue 16, 1996, Pages 1217-1222

  Miller, Charles E ^a   Karpas, Arthur ^b   Schneerson, Rachel ^b   Huppi, Konrad ^c   Kováĉ, Pavol ^a   Pozsgay, Vince ^b   Glaudemans, Cornelis P J ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

antibodies; carbohydrates; sequences; shigella

Indexed keywords

BACTERIUM ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; POLYSACCHARIDE;

AMINO ACID SEQUENCE; ARTICLE; DNA SEQUENCE; IMMUNOGLOBULIN GENE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SHIGELLA DYSENTERIAE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; BINDING, COMPETITIVE; CARBOHYDRATE SEQUENCE; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; O ANTIGENS; POLYSACCHARIDES, BACTERIAL; SEQUENCE HOMOLOGY, AMINO ACID; SHIGELLA DYSENTERIAE;

EID: 0037958926     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(96)00105-8     Document Type: Article

References (28)

1. Bennett L. G., Glaudemans C. P. J. (1979) The affinity of a (1→ 6) linked linear dextran for homogeneous immunoglobulin A W3129. Carbo. Res. 72, 315-319.
2. Borden P. and Kabat E. A. (1987) Nucleotide Sequence of the cDNAs encoding the variable light and heavy chains of an immunoglobulin specific for the terminus of an α-1,6 dextran. Proc. natn. Acad. Sci. U.S.A. 84, 2440-2443.
3. Chu C., Liu B., Watson D., Szu S., Bryla D., Shiloach J., Schneerson R. and Robbins J. B. (1991) Preparation, characterization and immunogenicity of conjugates composed of the O-specific polysaccharide of Shigella dysenteriae type 1 bound to tetanus toxoid. Infect. Immun. 59, 4450-4458.
4. Dmitriev B. A., Knirel N., Kotchetkov N. K. and Hofman I. L. (1976) Somatic antigens of Shigella. Structural Investigations on the O-polysaccharide chain of Shigella dysenteriae type 1 lipopolysaccharide. Eur. J. Biochem. 66, 559-566.
5. Fattom A., Schneerson R., Szu S., Vann W. F., Shiloach J., Karakawa W. W. and Robbins J. B. (1990) Synthesis and immunologic properties in mice of vaccines composed of Staphylococcus Aurus type 5 and type 8 capsular polysaccharides conjugated to Pseudomonas aeruginosa exotoxin A. Infect. Immun. 58, 2367-2374.
6. Glaudemans C. P. J. (1987) Seven structurally different galactan-specific antibodies show identity in their galactosyl-binding subsite arrangements. Mol. Immun. 24, 371-377.
7. Glaudemans C. P. J., Bennett L. G., Bhattacharjee A. K., Nashed E. M. and Ziegler T. ( 1993) Distinguishing antibodies that bind internal antigenic determinants from those that bind the antigenic chain terminus only. A. C. S. Symp. Series 519, 72-79.
8. Glaudemans C. P. J., Kovac P. and Rao A. S. (1989) The subsites of monoclonal antidextran IgA W3129. Carbo. Res. 190, 267-277.
9. Kabat E. A., Wu T. T., Perry H. M., Gottesman K. S. and Foeller C. (1991) Sequences of proteins of immunological interest, U. S. Dept. of Health and Human Services. NIH Publication 91-3242, NIH, Bethesda, Maryland.
10. Kovac P. and Edgar K. J. (1992) Synthesis of ligands related to the O-specific antigen of Type 1 Shigella dysenteriae. 3. Glycosylation of O-substituted derivatives of methyl-2-acetamido-2-deoxy-α-D-glucopyranoside with glycosyl donors derived from mono-and oligo-saccharides. J. Org. Chem. 57, 2455-2467.
11. Levine M. M., Dupont H. L., Formal S. B., Hornick R. B., Takeuchi A., Snyder M. J. and Libonati J. P. (1973) Pathogenesis of Shigella dysenteriae 1 (Shiga) dysentery. J. Infect. Dis. 127, 261-270.
12. Matsuda T. and Kabat E. A. (1989) Variable region cDNA sequences and antigen binding specificity of mouse monoclonal antibodies to isomaltosyl oligosaccharides coupled to proteins. J. Immun. 142, 863-870.
13. Miller C. E., Huppi K., Siwarski D., Karpas A., Newman A., Mainhart C. and Glaudemans C. P. J. (1995) A murine antibody to Shigella dysenteriae type 1 employs V-genes that contain a rearranged codon for th λ-light chain. Mol. Immun. 32, 679-682.
14. MMWR (1991) Shigella dysenteriae in Guatemala. Morbidity and Mortality Weekly Report, 40, 421-427.
15. Nashed E. M., Perdomo G. R., Padlan E. A., Kovac P., Matsuda T., Kabat E. A. and Glaudemans C. P. J. (1990) Binding characteristics of IgA 16·4.12E, a monoclonal antibody with specificity for the terminal epitope of α-(1,6)-dextrans, Comparisons between IgAs 16·4.12E and W3129. J. Biol. Chem. 265, 20699-20707.
16. Ollier P., Rocca-Serra J., Somme G., Theze J. and Fougereau M. (1985) The idiotypic network and the internal image: possible regulation of a germ-line network by paucigene enco· ded Ab2 (anti-idiotypic) antibodies in the Gat system. EMBO J. 4, 3681-3688.
17. Pavliak V., Kovac P. and Glaudemans C. P. J. (1992) Stereoselective synthesis of a di-, tri-and tetra-saccharide fragment of Shigella dysenteriae Type 1 O-antigen using 3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-glucopyranosylchloride as a glycosyl donor. Carbo. Res. 229, 103-116.
18. Pavliak V., Nashed E., Pozsgay V., Kovac P., Karpas A., Chu C., Schneerson R., Robbins J. R. and Glaudemans C. P. J. (1993) Binding of the O-antigen of Shigella dysenteriae type 1 and 26 related synthetic fragments to a monoclonal IgM antibody. J. Biol. Chem. 268, 25797-25802.
19. Pozsgay V., Brisson J. R. and Jennings H. J. (1987) Synthetic oligosaccharides related to Group B streptococcal polysaccharides. The rhamnotriose moiety of the common antigen. Can. J. Chem. 65, 2764-2769.
20. Pozsgay V., Coxon B. and Yeh H. (1993) Syntheses of di-to penta-saccharides related to the specific polysaccharide of Shigella dysenteriae type 1, and NMR studies. Bioorg. Med. Chem. 1, 237-257.
21. Pozsgay V. and Pannell L. (1994) Convergent synthesis of an octasaccharide fragment of the O-specific polysaccharide of Shigella dysenteriae type 1. Carbo. Res. 258, 105-122.
22. Robbins J. B., Chu C. and Schneerson R. (1992) Hypothesis for vaccine development. Clin. Infect. Dis. 15, 346-361.
23. Rouse D. A., Morris S. L., Karpas A. B., Probst P. G. and Chaperas S. D. (1990) Production, characterization and species specificity of monoclonal antibodies to Mycobacterium avium complex protein antigens. Infect. Immun. 58, 1445-1449.
24. Sambrook J., Fritsch E. F. and Maniatis T. (1989) In: Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press.
25. Schiff C. and Fougereau M. (1989) Determination of the primary structure of a mouse IgG2a. Eur. J. Biochem. 59, 525-537.
26. Taylor D. N., Trofa A. C., Sadoff J., Chu C., Bryla D., Shiloach J., Cohen D., Ashkenazi S., Lerman Y., Egan W., Schneerson R. and Robbins J. B. (1993) Synthesis, characterization and clinical evaluation of conjugate vaccines composed of the O-specific polysaccharides of Shigella dysenteriae, Type 1, Shigella flexneri, Type 2a, and Shigella sonnei (Plesiomonas shigelloides) bound to bacterial toxoids. Infect. Immun. 61, 3678-3687.
27. WHO, Committee on Biological Standardization (1977) World Health Organization, Technical Report Series, Vol. 610, Geneva, Switzerland.
28. Ziegler T., Sutorius H. and Glaudemans C. P. J. (1992) Binding studies on internal immunodeterminants. Carbo. Res. 229, 271-291.