What is known about St John's wort? Phytochemistry and pharmacology;Was ist bekannt über Johanniskraut? Phytochemie und pharmakologie

Pharmazie in Unserer Zeit

Volumn 32, Issue 3, 2003, Pages 212-219

  Butterweck, Veronika ^a   Nahrstedt, Adolf ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FLAVONOID; HYPERFORIN; HYPERICIN; HYPERICUM PERFORATUM EXTRACT; HYPERIN; ISOQUERCITRIN; PSEUDOHYPERICIN; RUTOSIDE;

ARTICLE; DEPRESSION; DRUG ACTIVITY; DRUG INDICATION; HUMAN; PHYTOCHEMISTRY;

ANIMALS; BRAIN CHEMISTRY; FLAVONOIDS; HUMANS; HYPERICUM; PLANT EXTRACTS; XANTHINES;

EID: 0037958505     PISSN: 00483664     EISSN: None     Source Type: Journal    
DOI: 10.1002/pauz.200390067     Document Type: Article

References (14)

1. Nahrstedt, A., Butterweck, V.: Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry 30 (1997) (Supplement 2) 129-134.
2. Baureithel, K.H., Bueter, K.B., Engesser, A., Burkard, W., Schaffner, W.: Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum. Pharm. Acta Helv. 72 (1997) 153-157.
3. Butterweck, V. et al.: In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs. Psychopharmacology 162 (2002) 193-202.
4. Butterweck,V., Jürgenliemk, G., Nahrstedt, A., Winterhoff, H.: Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test. Planta Med. 66 (2000) 3-6.
5. Nöldner, M., Schotz, K.: Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test. Planta Med. 68 (2002) 577-580.
6. Falk, H., Schmitzberger, W.: On the nature of "soluble" hypericin in Hypericum species. Monatshefte Chem. 123 (1992) 731-739.
7. Brockmöller, J., Reum, T., Bauer, S., Kerb, R., Hübner, W.D., Roots, I.: Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans. Pharmacopsychiatry 30 (1997) (Supplement 2) 94-101.
8. Butterweck, V., Petereit, F., Winterhoff, H., Nahrstedt, A.: Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Med. 64 (1998) 291-294.
9. Butterweck, V., Lieflaender-Wulf, U., Winterhoff, H., Nahrstedt, A.: Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: A pharmacokinetic study in rats. Planta Med. 69 (2003) 189-192.
10. Delbende, C. et al.: Glucocorticoids, Transmitters and Stress. Brit. J. Psychiat. 160 (Suppl. 15) (1992) 24-34.
11. Nemeroff, C.B. et al.: Elevated concentrations of corticotropin releasing-factor-like immunoreactivity in depressed patients. Science 226 (1984) 1342-1344.
12. Müller, W.E., Singer, A., Wonnemann, M.: Hyperforin - Antidepressant activity by a novel mechanism of action. Pharmacopsychiatry 34 (2001) S98-S102.
13. Laakmann, G., Schule, C., Baghai, T., Kieser, M.: St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry 31 (1998) (Supplement 1) 54-59.
14. Brattström, A.: Der Johanniskrautextrakt Ze 117. Dtsch. Apoth. Ztg. 142 (2002) 3695-3699.