Characterization of the antigen specificity and TCR repertoire, and TCR-based DNA vaccine therapy in myelin basic protein-induced autoimmune encephalomyelitis in DA rats

Journal of Immunology

Volumn 170, Issue 12, 2003, Pages 6371-6378

  Miyakoshi, Akira ^a   Yoon, Won Kee ^a   Jee, Youngheun ^a   Matsumoto, Yoh ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; ENCEPHALITOGENIC PROTEIN; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; GENETIC CODE; IMMUNIZATION; LYMPH NODE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; RAT; RAT STRAIN; SEQUENCE ANALYSIS; SPINAL CORD; T LYMPHOCYTE;

EID: 0037942682     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.12.6371     Document Type: Article

References (35)

1. Burns, F. R., X. Li, N. Shen, H. Offner, Y. K. Chou, A. A. Vandenbark, and E. Heber-Katz. 1989. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J. Exp. Med. 169:27.
2. Gold, D. P., H. Offner, D. Sun, S. Wiley, A. A. Vandenbark, and D. B. Wilson. 1991. Analysis of T cell receptor β chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. J. Exp. Med. 174:1467.
3. Zhang, X., and E. Heber-Katz. 1992. T cell receptor sequences from encephalitogenic T cells in adult Lewis rats suggest an early ontogenic origin. J. Immunol. 148:746.
4. Kim, G., N. Tanuma, T. Kojima, K. Kohyama, Y. Suzuki, Y. Kawazoe, and Y. Matsumoto. 1998. CDR3 size spectratyping and sequencing of spectratype-derived T cell receptor of spinal cord T cells in autoimmune encephalomyelitis. J. Immunol. 160:509.
5. Kim, G., K. Kohyama, N. Tanuma, H. Arimoto, and Y. Matsumoto. 1998. Persistent expression of autoimmune encephalomyelitis (EAE)-specific Vβ8.2 TCR spectratype in the central nervous system of rats with chronic relapsing EAE. J. Immunol. 161:6993.
6. Stepaniak, J. A., N. A. Wolf, D. Sun, and R. H. Swanborg. 1997. Interstrain variability of autoimmune encephalomyelitis in rats: multiple encephalitogenic myelin basic protein epitopes for DA rats. J. Neuroimmunol. 78:79.
7. Lenz, D. C., N. A. Wolf, and R. H. Swanborg. 1999. Strain variation in autoimmunity: attempted tolerization of DA rats results in the induction of experimental autoimmune encephalomyelitis. J. Immunol. 163:1763.
8. Sercarz, E. E., P. L. Lehmann, A. Ametani, G. Benichou, A. Miller, and K. Moudgil. 1993. Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol. 11:729.
9. Deibler, G. E., R. E. Martenson, and M. W. Kies. 1972. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Prep. Biochem. 2:139.
10. Matsumoto, Y., and M. Fujiwara. 1987. The immunopathology of adoptively transferred experimental allergic encephalomyelitis (EAE) in Lewis rats. I. Immunohistochemical examination of developing lesion of EAE. J. Neurol. Sci. 77:35.
11. Tsuchida, M., Y. Matsumoto, H. Hirahara, H. Hanawa, K. Tomiyama, and T. Abo. 1993. Preferential distribution of Vβ8.2-positive cells in the central nervous system of rats with myelin basic protein-induced autoimmune encephalomyelitis. Eur. J. Immunol. 23:2399.
12. Kim, G., K. Kohyama, N. Tanuma, and Y. Matsumoto. 1998. Diagnosis and assessment of preclinical and clinical autoimmune encephalomyelitis using peripheral blood TCR. Eur. J. Immunol. 28:2751.
13. Rock, E. P., P. R. Sibbald, M. M. Davis, and Y.-H. Chien. 1994. CDR3 length in antigen-specific immune receptors. J. Exp. Med. 179:323.
14. Waisman, A., P. Ruiz, D. L. Hirschberg, A. Gelman, J. R. Oksenberg, S. Brocke, F. Mor, I. R. Cohen, and L. Steinman. 1996. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat. Med. 2:899.
15. Lorentzen, J. C., S. Issazadeh, M. Storch, M. I. Mustafa, H. Lassman, C. Linington. L. Klareskog, and T. Olsson. 1995. Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant. J. Neuroimmunol. 63:193.
16. Diab, A., J. Zhu, B. G. Xiao, M. Mustafa, and H. Link. 1997. High IL-6 and low IL-10 in the central nervous system are associated with protracted relapsing EAE in DA rats. J. Neuropathol. Exp. Neurol. 56:541.
17. Stepaniak, J. A., K. E. Gould, D. Sun, and R. H. Swanborg. 1995. A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats. J. Immunol. 155:2762.
18. Bouwer, H. G. A., and D. J. Hinrichs. 1997. Experimental allergic encephalomyelitis and vaccination-induced resistance in DA rats. Cell. Immunol. 175:92.
19. Smeltz, R. B., N. A. Wolf, and R. H. Swanborg. 1998. Delineation of two encephalitogenic myelin basic protein epitopes for DA rats. J. Neuroimmunol. 87:43.
20. Matsumoto, Y., Y. Jee, G. Kim, and N. Tanuma. 2000. Fine TCR repertoire analysis of spinal cord T cells responding to the major and minor epitopes of myelin basic protein during rat autoimmune encephalomyelitis. J. Neurosci. Res. 59:145.
21. Matsumoto, Y., Y. Jee, and M. Sugisaki. 2000. Successful TCR-based immunotherapy for autoimmune myocarditis with DNA vaccines after rapid identification of pathogenic TCR. J. Immunol. 164:2248.
22. Mor, E., and I. R. Cohen. 1995. Pathogenicity of T cells responsive to diverse cryptic epitopes of myelin basic protein in the Lewis rat. J. Immunol. 155:3693.
23. Jee, Y., and Y. Matsumoto. 2001. Two-step activation of T cells, clonal expansion and subsequent Th1 cytokine production, is essential for the development of clinical autoimmune encephalomyelitis. Eur. J. Immunol. 31:1800.
24. Matsumoto, Y., K. Kawai, and M. Fujiwara. 1990. Analysis of the T cell repertoire for myelin basic protein in thymus-grafted and other types of chimera: evidence that major histocompatibility complex molecules on accessory cells rather than T cell specificity mainly regulate susceptibility to autoimmune encephalomyelitis. Eur. J. Immunol. 20:2119.
25. Lipham, W. J., T. M. Redmond, H. Takahashi, J. A. Berzofsky, B. Wiggert, G. J. Chder, and I. Gery. 1991. Recognition of peptides that are immunopathogenic but cryptic: mechanisms that allow lymphocytes sensitized against cryptic peptides to initiate pathogenic autoimmune processes. J. Immunol. 146:3757.
26. k-restricted determinant of hen egg lysozyme: limitation of lymph node proliferation studies in defining immunodominance and crypticity. Proc. Natl. Acad. Sci. USA 92:2214.
27. Kääb, G., G. Brandl, A. Marx, H. Wekerle, and M. Brandl. 1996. The myelin basic protein-specific T cell repertoire in (transgenic) Lewis rat/SCID mouse chimeras: preferential Vβ8.2 T cell receptor usage depends on an intact Lewis thymic microenvironment. Eur. J. Immunol. 26:981.
28. Kääb, G., I. Haarmann, H. Wekerle, and M. Bradl. 1998. The myelin basic protein-specific T cell repertoire in Lewis rats: T cell receptor diversity is influenced both by intrathymic milieu and by extrathymic peptide presentation. Eur. J. Immunol. 28:1499.
29. Targoni, O. S., and P. V. Lehmann. 1998. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J. Exp. Med. 187:2055.
30. Harrington, C. J., A. Paez, T. Hunkapiller, V. Mannikko, T. Brabb, M. Ahearn, C. Beeson, and J. Goverman. 1998. Differential tolerance is induced in T cells recognizing distinct epitopes in myelin basic protein. Immunity 8:571.
31. Klein, L., M. Klugmann, K. Nave, V. K. Tuohy, and B. Kyewski. 2000. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6:56.
32. Anderson, A. C., L. B. Nicholson, K. L. Legge, V. Turchin, H. Zaghouani, and V. K. Kuchroo. 2000. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J. Exp. Med. 191:761.
33. Egwuagu, C. E., P. Charukamnoetkanok, and I. Gery. 1997. Thymic expression of autoantigens correlates with resistance to autoimmune disease. J. Immunol. 159:3109.
34. Liu, H., A. J. MacKenzie-Graham, S. Kim, and R. R. Voskuhl. 2001. Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance. J. Neuroimmunol. 115:118.
35. Asmuss, A., K. Hofmann, T. Hochgrebe, G. Giegerich, T. Huenig, and T. Herrmann. 1996. Alleles of highly homologous rat T cell receptor β-chain variable segments 8.2 and 8.4: strain-specific expression, reactivity to superantigens, and binding of the mAb R78. J. Immunol. 157:4436.