Altered balance of half-reactions in p-hydroxybenzoate hydroxylase caused by substituting the 2′-carbon of FAD with fluorine

Journal of Biological Chemistry

Volumn 278, Issue 25, 2003, Pages 22210-22216

  Palfey, Bruce A ^a   Murthy, Yerramilli V S N ^b   Massey, Vincent ^c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b IDEXX Pharmaceutics Inc   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; ENZYMES; FLUORINE; HYDROXYLATION; SOLVENTS; SUBSTRATES;

HALF-REACTIONS;

PROTEINS;

2' FLUORO 2' DEOXYARABINOFLAVINE ADENINE NUCLEOTIDE; 4 HYDROXYBENZOATE 3 MONOOXYGENASE; 4 HYDROXYBENZOIC ACID; APOENZYME; BETA RESORCYLIC ACID; CARBON; FLAVINE ADENINE NUCLEOTIDE; FLUORINE; OXYGENASE; QUERCETIN; QUERCETIN DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROL; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME RECONSTITUTION; HYDROXYLATION; LIGAND BINDING; OXIDATION; PRIORITY JOURNAL; REDUCTION; SPECTROSCOPY;

4-HYDROXYBENZOATE-3-MONOOXYGENASE; BINDING SITES; CLONING, MOLECULAR; ESCHERICHIA COLI; FLAVIN-ADENINE DINUCLEOTIDE; FLUORINE; KINETICS; LIGANDS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY;

EID: 0037929203     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301830200     Document Type: Article

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