A new mutation, ataxia and male sterility (ams), of autoimmune-prone MRL/Ipr mouse is not linked to Ipr gene but associated with reduction of spleen size and alteration of lymphocyte subpopulations

Pathology International

Volumn 53, Issue 6, 2003, Pages 390-395

  Pineda, Liliam L ^a   Nakano, Akinobu ^a   Iijima, Masaaki ^a   Wada, Masahiro ^a   Yamasaki, Yoji ^a   Harada, Takayuki ^a  

^a SHIMANE UNIVERSITY   (Japan)

Author keywords

Ataxia and male sterility mouse; Genetic variant; Ipr gene; Lymphoid subpopulation; Spleen

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CONCANAVALIN A;

AMS MOUSE; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; BODY WEIGHT; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENE; GENE MUTATION; GENETIC LINKAGE; GENETIC VARIABILITY; GENETICS; HETEROZYGOSITY; HOMOZYGOSITY; IMMUNE RESPONSE; IMMUNE SYSTEM; IN VITRO STUDY; IPR GENE; LYMPH NODE; LYMPHOCYTE SUBPOPULATION; MALE; MALE INFERTILITY; MALE STERILITY; MONOCYTE; MOUSE; MOUSE MUTANT; MOUSE STRAIN; MRL IPR MOUSE; NONHUMAN; ORGAN WEIGHT; PATHOLOGY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SPLEEN; SPLEEN CELL; SPLEEN SIZE; SPLEEN WEIGHT;

ANIMALS; ATAXIA; AUTOIMMUNITY; BODY WEIGHT; CONCANAVALIN A; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INFERTILITY, MALE; LINKAGE (GENETICS); LYMPHOCYTE SUBSETS; MALE; MICE; MICE, INBRED MRL LPR; MICE, NEUROLOGIC MUTANTS; ORGAN SIZE; SPLEEN;

EID: 0037924417     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1827.2003.01486.x     Document Type: Article

References (13)

1. Harada T, Omura K, Wada M, Nakano A. A new mutant arising in MRL/Ipr mouse that manifests ataxia and male sterility. Acta Histochem Cytochem 1996; 29: 1002-3.
2. Harada T, Pineda LL, Nakano A et al. Ataxia and male sterility (AMS) mouse. A new genetic variant exhibiting degeneration and loss of Purkinje cells and spermatic cells. Pathol Int 2003; 53: 382-9.
3. Murphy ED, Roths JB. Autoimmunity and lymphoproliferation; Induction by mutant gene Ipr, and acceleration by a male-associated factor in strain BXSB mice. In: Rose NR, Bigazzi PE, Warner NL, eds. Genetic Control of Autoimmune Disease. North Holland: Elsevier, 1973; 207-21.
4. Cohen PL, Eisenberg RA. LPR and GLD: single gene models of systemic autoimmunity and lymphoproliferative disease. Ann Rev Immunol 1991; 9: 243-69.
5. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediate apoptosis. Nature 1992; 356: 314-7.
6. Wu J, Zhou T, He J, Mountz JD. Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene. J Exp Med 1993; 178: 461-8.
7. Guidelines for Animal Experimentation, Shimane Medical University. Guide for the Use of Institute and Experimental Animals. Izumo, Japan: Shimane Medical University, 1999.
8. Murphy ED, Roths JB. A single gene model for massive lymphoproliferation with immune complex disease in new mouse strain MRL. In: Proceeding of the 16th International Congress of Hematology. Amsterdam: Excerpta Medica, 1976; 69.
9. Mishell BB, Shiigi SM, eds. Selected Methods in Cellular Immunology. San Francisco: WH Freeman, 1980; 23.
10. Zhang W, Ghetti B, Yang X-L, Lee W-H. Alteration of IGF system gene expression during the postnatal development of pcd mice. J Endocrinol 1999; 163: 191-8.
11. Agou A, Gotou H, Suzuki S. [Feed for experimental animals. III. Difference of intake among five mouse strains of non-treated and autoclave-sterilized pellets.] J Exp Anim Technol 1989; 24: 22-7. (In Japanese.)
12. Clea Japan. Inbred animais. Clea Japan, Osaka, 2002. Available at URL: http://www.clea-japan.co.jp/animals/b6-3.htm.
13. Roths JB. Differential expression of murine autoimmunity and lymphoid hyperplasia determined by single genes. In: Kyougou M, Wigzell H, eds. New Horizons in Animal Models for Autoimmune Disease. Tokyo: Academic Press, 1987; 21-33.