Building a better tuberculosis vaccine

Nature Medicine

Volumn 9, Issue 5, 2003, Pages 503-504

  Young, Douglas B ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE;

BACTERIAL VIRULENCE; BCG VACCINATION; DRUG EFFICACY; GENETIC ANALYSIS; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; SHORT SURVEY;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BCG VACCINE; GENE DELETION; HUMANS; TUBERCULOSIS; VACCINES, SYNTHETIC;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS;

EID: 0037902486     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm868     Document Type: Short Survey

References (9)

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3. Pym, A.S., Brodin, P., Brosch, R., Huerre, M. & Cole, S.T. Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. Mol. Microbiol. 46, 709-712 (2002).
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7. Horwitz, M.A., Harth, G., Dillon, B.J. & MaslesaGalic, S. Recombinant Bacillus Calmette-Guérin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc. Natl. Acad. Sci. USA 97, 13853-13858 (2000).
8. Cole, S.T. et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544 (1998).
9. Gey Van Pittius, N.C. et al. The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria. Genome Biol. 2, 1-18 (2001).