The prognostic value of FISH as an adjunct to conventional cytogenetics for the detection of cryptic gene rearrangements on chromosome 16. A retrospective investigation of 13 patients from Northern Ireland diagnosed with M4Eo acute myeloid leukemia

Ulster Medical Journal

Volumn 72, Issue 1, 2003, Pages 16-21

  McGrattan, P ^a   Humphreys, M W ^a  

^a ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER SURVIVAL; CHROMOSOME 16Q; CHROMOSOME BANDING PATTERN; CHROMOSOME DELETION; CHROMOSOME DELETION 16; CHROMOSOME INVERSION; CHROMOSOME INVERSION 16; CHROMOSOME TRANSLOCATION 16; CLINICAL ARTICLE; CYTOGENETICS; DIAGNOSTIC ERROR; DIAGNOSTIC VALUE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HUMAN; INTERMETHOD COMPARISON; MALE; NUMERICAL CHROMOSOME ABERRATION; PROGNOSIS; RETROSPECTIVE STUDY; SEQUENCE HOMOLOGY; STRUCTURAL CHROMOSOME ABERRATION; UNITED KINGDOM;

ADULT; AGED; AGED, 80 AND OVER; CHI-SQUARE DISTRIBUTION; CHROMOSOMES, HUMAN, PAIR 16; CYTOGENETIC ANALYSIS; FEMALE; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INVERSION, CHROMOSOME; LEUKEMIA, MYELOMONOCYTIC, ACUTE; MALE; MIDDLE AGED; NORTHERN IRELAND; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; TRANSLOCATION, GENETIC;

EID: 0037897821     PISSN: 00416193     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Schiffer C A, Lee E J, Tomiyasu T, Wiernik P H, Testa J R. Prognostic impact of cytogenetic abnormalities in patients with de novo nonlymphocytic leukemia. Blood 1989; 73(1): 263-70.
2. Baer M R Bloomfield C D. Cytogenetics and oncogenes in leukemia. Curr Opin Oncol 1992; 4(1): 24-32.
3. Dastugue N, Payen C, Lafage-Pochitaloff M, Bernard P, Leroux D, Huguet-Rigal F. Prognostic significance of karyotype in de novo adult acute myeloid leukemia. The BGMT group. Leukemia 1995; 9(9): 1491-8.
4. Burnett A K, Goldstone A H, Stevens R, Hann I, Rees J K, Wheatley K. Biological characteristics of disease determine the outcome of allogeneic or autologous BMT in AML CR1. Blood 1995; 86 (Suppl 1): 2452a.
5. Le Beau M M, Larson R A, Bitter M A, Vardiman J W, Golomb H M, Rowley J D. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association. N Eng J Med 1983; 309(11): 630-6.
6. Ritter M, Thiede C, Schäkel U, Schmidt M, Alpen B, Pascheberg U. Underestimation of inversion (16) in acute myeloid leukaemia using standard cytogenetics as compared with polymerase chain reaction: results of a prospective investigation. Br J Haematol 1997; 98(4): 969-72.
7. Mitelman F (editor). ISCN 1995: International System for Human Cytogenetic Nomenclature. Basel: Karger 1995.
8. Ohyashiki K, Ohyashiki J H, Kondo M, Ito H, Toyama K. Chromosome change at 16q22 in nonlymphocytic leukemia: clinical implication on leukemia patients with inv(16) versus del(16). Leukemia 1988; 2(1): 35-40.
9. Grois N, Novotny H, Tyl E, Krieger O, Kier P, Hass O A. Is trisomy 22 in acute myeloid leukemia a primary abnormality or only a secondary change associated with inv16?. Cancer Genet Cytogenet 1989; 43(1): 119-29.
10. Marlton P, Keating M, Kantaijian H, Pierce S, O'Brien S, Freireich E J, et al. Cytogenetic and clinical correlates in AML patients with abnormalities of chromosome 16. Leukemia 1995; 9(6): 965-71.
11. Betts D R, Rohatiner A Z, Evans M L, Rassam S M, Lister T A, Gibbons B. Abnormalities of chromosome 16q in myeloid malignancy: 14 new cases and a review of the literature. Leukemia 1992; 6(12): 1250-6.
12. Larson R A, Williams S F, Le Beau M M, Bitter M A, Vardiman J W, Rowley J D. Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favourable prognosis. Blood 1986; 68(6): 1242-49.