Conformationally Constrained DNA Mimics: Synthesis of a Novel Cyclopropyl-Amide Linked Dimer

Synlett

Volumn 1996, Issue 7, 1996, Pages 687-689

  Haly, Becky ^a   Bharadwaj, Ramesh ^a   Sanghvi, Yogesh S ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0037883648     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1996-5570     Document Type: Article

References (34)

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2. Sanghvi, Y.S.; Cook, P.D. In Nucleosides and Nucleotides as Antitumor and Antiviral Agents; Chu, C. K.; Baker, D.C., Eds.; Plenum Press: New York, 1993; p 311. Varma, R.S. Synlett 1993, 621. Sanghvi, Y.S.; Cook, P.D. In Carbohydrate Modifications in Antisense Research, ACS Symposium Series 580; Sanghvi, Y.S.; Cook, P.D., Eds.; American Chemical Society: Washington DC, 1995; p 1.
3. Sanghvi, Y.S.; Cook, P.D. In Nucleosides and Nucleotides as Antitumor and Antiviral Agents; Chu, C. K.; Baker, D.C., Eds.; Plenum Press: New York, 1993; p 311. Varma, R.S. Synlett 1993, 621. Sanghvi, Y.S.; Cook, P.D. In Carbohydrate Modifications in Antisense Research, ACS Symposium Series 580; Sanghvi, Y.S.; Cook, P.D., Eds.; American Chemical Society: Washington DC, 1995; p 1.
4. Morvan, F.; Sanghvi, Y.S.; Perbost, M.; Vasseur, J-J.; Bellon, L. J. Am. Chem. Soc. 1996, 118, 255; and references cited therein.
5. For a comprehensive list see: Uhlmann, E.; Peymann, A. In Protocols for Oligonucleotides and Analogs; Agrawal, S., Ed.; Humana Press: Totowa, NJ, 1993; p 355. De Mesmaeker, A.; Altmann, K-H.; Waldner, A.; Wendeborn, S. Curr. Opin. Struct. Biol. 1995, 34, 5417.
6. For a comprehensive list see: Uhlmann, E.; Peymann, A. In Protocols for Oligonucleotides and Analogs; Agrawal, S., Ed.; Humana Press: Totowa, NJ, 1993; p 355. De Mesmaeker, A.; Altmann, K-H.; Waldner, A.; Wendeborn, S. Curr. Opin. Struct. Biol. 1995, 34, 5417.
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11. De Mesmaeker, A.; Waldner, A.; Sanghvi, Y.S.; Lebreton, J. Bioorg. Med. Chem. Lett. 1994, 4, 395. Griffey, R.H.; Lesnik, E.; Freier, S.M.; Sanghvi, Y.S.; Teng, K.; Kawasaki, A.; Guinosso, C.; Wheeler, P.; Mohan, V.; Cook, P.D. In Carbohydrate Modifications in Antisense Research, ACS Symposium Series 580; Sanghvi, Y.S.; Cook, P.D., Eds.; American Chemical Society: Washington DC, 1995; p 1.
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20. Purchased from Summit Pharmaceutical, Fort Lee, NJ 07024; Tel: 201-585-9563; Fax: 201-585-9653.
21. Sanghvi, Y.S. In Antisense Research and Applications; Crooke, S.T.; Leblue, B., Eds.; CRC Press: Boca Raton, FL, 1993; p 274.
22. The epoxide 8 was prepared via the literature procedure: Bamford, M.J.; Coe, P.L.; Walker, R.T. J. Med. Chem. 1990, 33, 2494.
23. 6: C, 46.65; H, 4.63; N, 14.84. Found: C, 46.51; H 4.64; N, 14.58.
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29. We thank Dr. De Mesmaeker for sending us the procedure to prepare nucleoside analog 4. See reference 5 for details.
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33. See p 125 in reference 24.
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