A slow fraction of Mg2+ unblock of NMDA receptors limits their contribution to spike generation in cortical pyramidal neurons

Journal of Neurophysiology

Volumn 89, Issue 5, 2003, Pages 2778-2783

  Vargas Caballero, Mariana ^a   Robinson, Hugh P C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; CALCIUM ION; GLUTAMIC ACID; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; MAGNESIUM;

ANIMAL CELL; ARTICLE; KINETICS; MEMBRANE CONDUCTANCE; MEMBRANE ELECTROPHYSIOLOGY; MEMBRANE POTENTIAL; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; ACTION POTENTIAL; ALGORITHM; ANIMAL; BRAIN CORTEX; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; ELECTROPHYSIOLOGY; MALE; PATCH CLAMP; WISTAR RAT;

ACTION POTENTIALS; ALGORITHMS; ANIMALS; CEREBRAL CORTEX; ELECTROPHYSIOLOGY; MAGNESIUM; MALE; PATCH-CLAMP TECHNIQUES; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0037879348     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.01038.2002     Document Type: Article

References (28)

1. Ascher P and Nowak L. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurons in culture. J Physiol 399: 247-266, 1988.
2. Benveniste M and Mayer ML. Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9-aminoacridine. J Physiol 483: 367-384, 1995.
3. D'Angelo E, Rossi P, and Taglietti V. Voltage-dependent kinetics of N-methyl-D-aspartate synaptic currents in rat cerebellar granule cells. Eur J Neurosci 6: 640-645, 1994.
4. Forsythe ID and Westbrook GL. Slow excitatory postsynaptic currents mediated by N-methyl-D-aspartic acid receptors on cultured mouse central neurones. J Physiol 396: 515-533, 1988.
5. Hamill O, Marty A, Neher E, Sakmann B, and Sigworth FG. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluegers 391: 85-100, 1981.
6. Kirson ED, Schirra C, Konnerth A, and Yaari Y. Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells. J Physiol 521: 99-111, 1999.
7. Larkum ME, Zhu JJ, and Sakmann B. Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons. J Physiol 533: 447-466, 2001.
8. Lester RAJ, Clements JD, Westbrook CL, and Jahr CE. Channel kinetics determine the timecourse of NMDA receptor mediated synaptic currents. Nature 346: 565-567, 1990.
9. Lester RAJ and Jahr CE. NMDA channel behavior depends on agonist affinity. J Neurosci 12: 635-643, 1992.
10. Markram H, Lubke J, Frotscher M, and Sakmann B. Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275: 213-215, 1997.
11. 2+ of NMDA responses on spinal cord neurones. Nature 309: 261-264, 1984.
12. Mayer ML and Westbrook GL. The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture. J Physiol 361: 65-90, 1985.
13. Mayer ML and Westbrook GL. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones. J Physiol 354: 29-53, 1987.
14. Monyer H, Burnashev N, Laurie DJ, Sakmann B, and Seeburg PH. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529-540, 1994.
15. Nahum-Levy R, Lipinsky D, Shavit S, and Benveniste M. Desensitization of NMDA receptor channels is modulated by glutamate agonists. Biophys J 80: 2152-2166, 2001.
16. Neher E. Correction for liquid junction potentials in patch clamp experiments. Methods Enzymol 207: 123-131, 1992.
17. Nowak L, Brgestovsky P, Ascher P, Herbet A, and Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurons. Nature 307: 462-465, 1984.
18. Patneau D and Mayer M. Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. J Neurosci 10: 2385-2399, 1990.
19. Robinson HPC, Sahara Y, and Kawai N. Nonstationary fluctuation analysis and direct resolution of single channel currents at postsynaptic sites. Biophys J 59: 295-304, 1991.
20. Sather W, Dieudonne S, MacDonald JF, and Ascher P. Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones. J Physiol 450: 643-672, 1992.
21. Schiller J, Major G, Koester HJ, and Schiller Y. NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature 404: 285-289, 2000.
22. Schiller J and Schiller Y. NMDA receptor-mediated dendritic spikes and coincident signal amplification. Curr Opin Neurobiol 11: 343-348, 2001.
23. Sobolevsky AI and Yelshansky MV. The trapping block of NMDA receptor channels in acutely isolated rat hippocampal neurones. J Physiol 526: 493-506, 2000.
24. Spruston N, Jonas P, and Sakmann B. Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. J Physiol 482: 325-352, 1995.
25. Stern P, Edwards FA, and Sakmann B. Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex. J Physiol 449: 247-278, 1992.
26. Vargas-Caballero M and Robinson H. A millisecond timescale for unblocking of NMDA receptors after depolarisation. Biophys J 80: 105a, 2001.
27. 2+. J Physiol 506: 13-32, 1998.
28. Woodhull AM. Ionic blockage of sodium channels in nerve. J Gen Physiol 61: 687-708, 1973.