Gab1, SHP-2 and other novel regulators of Ras: Targets for anticancer drug discovery?

Current Cancer Drug Targets

Volumn 3, Issue 3, 2003, Pages 177-192

  Yart, Armelle ^a   Mayeux, Patrick ^b   Raynal, Patrick ^a  

^a CHU PURPAN   (France)

^b Hôpital Cochin ^*  (France)

Author keywords

Cancer; EGF receptor; Gab1; Phosphoinositide 3 kinase; Ras; SHP 2; Tyrosine kinase

Indexed keywords

ADAPTOR PROTEIN; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; GRB2 ADAPTER BINDER PROTEIN 1; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; RAS PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; CANCER; CANCER CHEMOTHERAPY; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL TRIAL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; HUMAN; NONHUMAN; ONCOGENE RAS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHOPROTEINS; PROTEIN-TYROSINE-PHOSPHATASE; RAS PROTEINS; TECHNOLOGY, PHARMACEUTICAL;

EID: 0037879096     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568009033481976     Document Type: Review

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