Dietary ethinyl estradiol exposure during development causes increased voluntary sodium intake and mild maternal and offspring toxicity in rats

Neurotoxicology and Teratology

Volumn 25, Issue 4, 2003, Pages 491-501

  Ferguson, Sherry A ^a   Delclos, K Barry ^a   Newbold, Retha R ^b   Flynn, Katherine M ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Endocrine disrupter; Ethinyl estradiol; Locomotor activity; Play behavior; Saccharin intake; Sodium intake

Indexed keywords

ETHINYLESTRADIOL; PHYTOESTROGEN; SACCHARIN; SODIUM CHLORIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR TERATOLOGY; BEHAVIORAL SCIENCE; BODY WEIGHT; CONTROLLED STUDY; CORRELATION ANALYSIS; DIETARY INTAKE; EMBRYOTOXICITY; FEMALE; FEMININITY; FETOTOXICITY; FOOD INTAKE; GENETIC CORRELATION; GESTATION PERIOD; GONAD FUNCTION; LOCOMOTION; MALE; MATERNAL NUTRITION; NEWBORN; NONHUMAN; NUTRIENT SOLUTION; OPEN FIELD BEHAVIOR; PERINATAL PERIOD; PLAY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RAT; RUNNING; SEX DIFFERENCE; SODIUM INTAKE; TOXICITY; WEANING;

EID: 0037869037     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(03)00015-1     Document Type: Article

References (71)

1. Adkins-Regan E. Testosterone increases singing and aggression but not male-typical sexual partner preference in early estrogen treated female zebra finches. Horm. Behav. 35:1999;65-70.
2. Adkins-Regan E., Orgeur P., Signoret J.P. Sexual differentiation of reproductive behavior in pigs: defeminizing effects of prepubertal estradiol. Horm. Behav. 23:1989;290-303.
3. Akiyama T., Ishida J., Nakagawa S., Ogawa H., Watanabe S., Itoh N.M., Shibuya M., Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262:1987;5592-5595.
4. Ansbacher R. Low-dose oral contraceptives: health consequences of discontinuation. Contraception. 62:2000;285-288.
5. Betrabet S.S., Shikary Z.K., Toddywalla V.A., Patel D., Vaidya P., Saxena B.N. ICMR Task Force Study on hormonal contraception. Biological activity of ethinyl estradiol present in breast milk. Contraception. 34:1986;169-175.
6. Blair R.M., Fang H., Branham W.S., Hass B.S., Dial S.L., Moland C.L., Tong W., Shi L., Perkins R., Sheehan D.M. The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands. Toxicol. Sci. 54:2000;138-153.
7. Bronson F.H., Desjardins C. Aggression in adult mice: modification by neonatal injections of gonadal hormones. Science. 161:1968;705-706.
8. Casanova M., You L., Gaido K.W., Archibeque-Engle S., Janszen D.B., Heck H.d'A. Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors α and β in vitro. Toxicol. Sci. 51:1999;236-244.
9. Chow S.Y., Sakai R.R., Witcher J.A., Adler N.T., Epstein A.N. Sex and sodium intake in the rat. Behav. Neurosci. 106:1992;172-180.
10. Clarke S.N.D.A., Bernstein H.L. NaCl preference increases during pregnancy and lactation: assessment using brief access tests. Pharmacol. Biochem. Behav. 68:2001;555-563.
11. Collaer M.L., Hines M. Human behavioral sex differences: a role for gonadal hormones during early development? Psychol. Bull. 118:1995;55-107.
12. Cooper R.L., Kavlock R.J. Endocrine disruptors and reproductive development: a weight-of-evidence overview. J. Endocrinol. 152:1997;159-166.
13. Covelli M.D., Denton D.A., Nelson J.F., Shulkes A.A. Hormonal factors influencing salt appetite in pregnancy. Endocrinology. 93:1973;423-429.
14. Csaba G., Dobozy O., Dallo J. Influence of neonatal steroid (diethylstilbestrol, allylestrenol) treatment on the sexual behavior of the adult rat. Med. Biol. 64:1986;193-195.
15. Darney P.D. OC practice guidelines: minimizing the side effects. Int. J. Fertil. Womens Med. (Suppl. 1):1997;158-169.
16. Dawson J.L., Cheung Y.M., Lau R.T. Developmental effects of neonatal sex hormones on spatial and activity skills in the white rat. Biol. Psychol. 3:1975;213-229.
17. Denton D.A., Nelson J.F. Effects of pregnancy and lactation on the mineral appetites of wild rabbits (Oryctolagus cuniculus). Endocrinology. 88:1971;31-40.
18. Denton D.A., Nelson J.F. The control of salt appetite in wild rabbits during lactation. Endocrinology. 103:1978;1880-1887.
19. Denton D.A., Nelson J.F. The influence of reproductive processes on salt appetite. Kare M.R., Fregley M.J., Bernard R.A. Biological and Behavioral Aspects of Salt Intake. 1980;229-246 Academic Press, New York.
20. Dugard M.L., Tremblay-Leveau H., Mellier D., Caston J. Prenatal exposure to ethinylestradiol elicits behavioral abnormalities in the rat. Dev. Brain Res. 129:2001;189-199.
21. Edwards D.A., Herndon J. Neonatal estrogen stimulation and aggressive behavior in female mice. Physiol. Behav. 5:1970;993-995.
22. Ehrhardt A.A., Meyer-Bahlburg H.F., Rosen L.R., Feldman J.F., Veridiano N.P., Elkin E.J., McEwen B.S. The development of gender-related behavior in females following prenatal exposure to diethylstilbestrol (DES). Horm. Behav. 23:1989;526-541.
23. Ehrhardt A.A., Meyer-Bahlburg H.F., Rosen L.R., Feldman J.F., Veridiano N.P., Zimmerman I., McEwen B.S. Sexual orientation after prenatal exposure to exogenous estrogen. Arch. Sex. Behav. 14:1985;57-77.
24. Fadem B.H. Perinatal exposure to estradiol masculinizes aspects of sexually dimorphic behavior and morphology in gray short-tailed opossums (Monodelphis domestica). Horm. Behav. 37:2000;79-85.
25. Ferguson S.A., Flynn K.M., Delclos K.B., Newbold R.R. Maternal and offspring toxicity but few sexually dimorphic behavioral alterations result from nonylphenol exposure. Neurotoxicol. Teratol. 22:2000;583-591.
26. Ferguson S.A., Flynn K.M., Newbold R.R. Chronic developmental methoxychlor (MET) treatment results in decreased body weight, but few behavioral alterations in rats. Neurotoxicol. Teratol. 21:1999;331-332.
27. Ferguson S.A., Racey F.D., Paule M.G., Holson R.R. Behavioral effects of methylazoxymethanol-induced micrencephaly. Behav. Neurosci. 107:1993;1067-1076.
28. Flynn F.W., Schulkin J., Havens M. Sex differences in salt preference and taste reactivity in rats. Brain Res. Bull. 32:1993;91-95.
29. Flynn K.M., Delclos K.B., Newbold R.R., Ferguson S.A. Behavioral responses of rats exposed to long term dietary vinclozolin. J. Agric. Food Chem. 49:2001;1658-1665.
30. Flynn K.M., Ferguson S.A., Delclos K.B., Newbold R.R. Effects of genistein exposure on sexually dimorphic behaviors in rats. Toxicol. Sci. 55:2000;311-319.
31. Fregly M.J., Newson D.G. Spontaneous NaCl appetite induced by administration of an oral contraceptive and its components to rats. Kare M.R., Fregley M.J., Bernard R.A. Biological and Behavioral Aspects of Salt Intake. 1980;247-272 Academic Press, New York.
32. Goldzieher J.W. Are low-dose oral contraceptives safer and better? Am. J. Obstet. Gynecol. 171:1994;587-590.
33. Golub M.S., Hayes L., Prahalada S., Hendrickx A.G. Behavioral tests in monkey infants exposed embryonically to an oral contraceptive. Neurobehav. Toxicol. Teratol. 5:1983;301-304.
34. Goy R.W., Deputte B.L. The effects of diethylstilbestrol (DES) before birth on the development of masculine behavior in juvenile female rhesus monkeys. Horm. Behav. 30:1996;379-386.
35. Gray J.A., Levine S., Broadhurst P.L. Gonadal hormone injections in infancy and adult emotional behavior. Anim. Behav. 13:1965;33-45.
36. Hart B.L. Neonatal dihydrotestosterone and estrogen stimulation: effects on sexual behavior of male rats. Horm. Behav. 8:1977;193-200.
37. Hines M. Abnormal sexual development and psychosexual issues. Ballieres Clin. Endocrinol. Metab. 12:1998;173-189.
38. Hines M., Alsum P., Roy M., Gorski R.A., Goy R.W. Estrogenic contributions to sexual differentiation in the female guinea pig: influences of diethylstilbestrol and tamoxifen on neural, behavioral, and ovarian development. Horm. Behav. 21:1987;402-417.
39. Hines M., Goy R.W. Estrogens before birth and development of sex-related reproductive traits in the female guinea pig. Horm. Behav. 19:1985;331-347.
40. Hines M., Shipley C. Prenatal exposure to diethylstilbestrol (DES) and the development of sexually dimorphic cognitive abilities and cerebral lateralization. Dev. Psychobiol. 20:1984;81-94.
41. Isgor C., Sengelaub D.R. Prenatal gonadal steroids affect adult spatial behavior, CA1 and CA3 pyramidal cell morphology in rats. Horm. Behav. 34:1998;183-198.
42. Krecek J. Sex differences in salt taste: the effect of testosterone. Physiol. Behav. 10:1973;683-688.
43. Krecek J. Effect of ovarectomy on females and oestrogen administration to males during the neonatal critical period on salt intake in adulthood in rats. Physiol. Bohemoslov. 27:1978;1-5.
44. Kuiper G.G.J.M., Lemmen J.G., Carlsson B., Corton J.C., Safe S.S., van der Saag P.T., van der Burg B., Gustafsson J. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β Endocrinology. 139:1998;4252-4263.
45. Kuiper G.G.J.M., Carlsson B., Gandien K., Enmark E., Haggblad J., Nilsson S., Gustafsson J.A. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β Endocrinology. 138:1997;863-870.
46. Levine S., Mullins R. Estrogen administered neonatally affects adult sexual behavior in male and female rats. Science. 144:1964;185-187.
47. MacLusky N.J., Naftolin F. Sexual differentiation of the central nervous system. Science. 211:1981;1294-1302.
48. McGivern R.F., Henschel D., Hutcheson M., Pangburn T. Sex difference in daily water consumption of rats: effect of housing and hormones. Physiol. Behav. 59:1996;653-658.
49. Meyer-Bahlburg H.F.L., Ehrhardt A.A., Endicott J., Veridiano N.P., Whitehead E.D., Vann F.H. Depression in adults with a history of prenatal DES exposure. Psychopharmacol. Bull. 21:1985;686-689.
50. Nilsson S., Nygren K.G., Johansson E.D. D-Norgestrel concentrations in maternal plasma, milk, and child plasma during administration of oral contraceptives to nursing women. Am. J. Obstet. Gynecol. 129:1977;178-184.
51. Palanza P., Parmigiani S., Liu H., vom Saal F.S. Prenatal exposure to low doses of the estrogenic chemicals diethylstilbestrol and o,p′-DDT alters aggressive behavior of male and female house mice. Pharmacol. Biochem. Behav. 64:1999;665-672.
52. Panksepp J. The ontogeny of play in rats. Dev. Psychobiol. 14:1981;327-332.
53. Pellis S.M., Pellis V.C., McKenna M.M. Feminine dimension of play fighting of rats (Rattus norvgegicus) and its defeminization neonatally by androgens. J. Comp. Psychol. 108:1994;68-73.
54. Roselli C.E., Klosterman S.A. Sexual differentiation of aromatase activity in the rat brain: effects of perinatal steroid exposure. Endocrinology. 139:1998;3193-3201.
55. Sanchez-Santed F., Cales J.M., Enriquez P., Guillamon A. Early postnatal estrogen organizes sex differences in the extinction of a CRF running response. Brain Res. Bull. 30:1993;649-653.
56. Santell R.C., Chang Y.C., Nair M.G., Helferich W.G. Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats. J. Nutr. 127:1997;263-269.
57. Sayag N., Robinzon B., Snapir N., Arnon E., Grimm V.E. The effects of embryonic treatments with gonadal hormones on sexually dimorphic behavior of chicks. Horm. Behav. 25:1991;137-153.
58. Schardein J.L. Studies of the components of an oral contraceptive agent in albino rats: I. Estrogenic component. J. Toxicol. Environ. Health. 6:1980;885-894.
59. Schlenker E.H., Goldman M., Walsh S. Perinatal estradiol benzoate administration affects control of ventilation in adult male rats. Physiol. Behav. 52:1992;1113-1116.
60. Schumacher M., Hendrick J.C., Balthazart J. Sexual differentiation in quail: critical period and hormonal specificity. Horm. Behav. 23:1989;130-149.
61. Simon N.G., Whalen R.E. Sexual differentiation of androgen-sensitive and estrogen-sensitive regulatory systems for aggressive behavior. Horm. Behav. 21:1987;493-500.
62. Smith L.L., Hines M. Language lateralization and handedness in women prenatally exposed to diethylstilbestrol (DES). Psychoneuroendocrinology. 25:2000;497-512.
63. Sohoni P., Sumpter J.P. Several environmental oestrogens are also anti-androgens. J. Endocrinol. 158:1998;327-339.
64. Stevens R., Goldstein R. Effects of neonatal testosterone and estrogen on open-field behaviour in rats. Physiol. Behav. 26:1981;551-553.
65. Swanson H.H. Alteration of sex-typical behaviour of hamsters in open field and emergence tests by neonatal administration of androgen or oestrogen. Anim. Behav. 15:1967;209-216.
66. Tilson H.A. Developmental neurotoxicology of endocrine disruptors and pesticides: identification of information gaps and research needs. Environ. Health Perspect. 106(Suppl. 3):1998;807-811.
67. Tilson H.A., Kavlock R.J. The workshop on endocrine disrupter research needs: a report. Neurotoxicology. 18:1997;389-392.
68. White R., Jobling S., Hoare S.A., Sumpter J.P., Parker M.G. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology. 135:1994;175-182.
69. Williams C.L., Barnett A.M., Meck W.H. Organization effects of early gonadal secretions on sexual differentiation in spatial memory. Behav. Neurosci. 104:1990;84-97.
70. Yoshimura H., Yoshida H., Ogawa N. Neonatal gonadal hormone treatments and adult open-field behavior in female rats. Jpn. J. Psychopharmacol. 2:1982;81-85.
71. Zadina J.E., Dunlap J.L., Gerall A.A. Modifications induced by neonatal steroids in reproductive organs and behavior of male rats. J. Comp. Physiol. Psychol. 93:1979;314-332.