Spinach makes a safer anthrax vaccine

Drug Discovery Today

Volumn 8, Issue 10, 2003, Pages 428-430

  Sussman, Hillary E ^a  

^a NONE

Author keywords

Anthrax; Drug Discovery; Edema toxin; Lethal toxin; Microbiology; Pharmaceutical Science; Plant based vaccines; Protective antigen (PA); Techniques Methods

Indexed keywords

ALUMINUM HYDROXIDE; ALUMINUM PHOSPHATE; ANTHRAX VACCINE; PROTECTIVE ANTIGEN; UNCLASSIFIED DRUG;

ANTHRAX; ANTIGEN EXPRESSION; BACILLUS ANTHRACIS; CELL FREE SYSTEM; CHRONIC FATIGUE SYNDROME; DEPRESSION; DNA MODIFICATION; DRUG COST; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG SCREENING; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNE RESPONSE; PERSIAN GULF SYNDROME; RASH; RISK FACTOR; SHORT SURVEY; SIDE EFFECT; SPINACH; VACCINATION;

ANIMALS; ANTHRAX VACCINES; BACILLUS ANTHRACIS; HUMANS; PHYTOTHERAPY; SPINACIA OLERACEA;

EID: 0037866426     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(03)02706-5     Document Type: Short Survey

References (8)

1. Karasev, A.V. et al. (2003) Production of the Bacillus anthracis Protective Antigen Fragments in Plants. American Society for Microbiology Biodefense Research Meeting, 9-12 March 2003, Baltimore, MD, USA (Abstract 73).
2. Steele L. Prevalence and patterns of Gulf War illness in Kansas veterans: association of symptoms with characteristics of person, place and time of military service. Am. J. Epidemiol. 152:2000;992-1002.
3. Future Needs. Joellenbeck L.M., et al. The Anthrax Vaccine: Is It Safe? Does It Work? 2002;198-210 National Academy Press.
4. Barnard J.P., Friedlander A.M. Vaccination against anthrax with attenuated recombinant strains of Bacillus anthracis that produce protective antigen. Infect. Immun. 67:1999;562-567.
5. Leppla S.H., et al. Development of an improved vaccine for anthrax. J. Clin. Invest. 110:2002;141-144.
6. Use of anthrax vaccine in the United States: recommendations of the Advisory Committee on Immunization Practices. MMWR Morb. Mortal. Weekly Rep. 49:2000;1-20.
7. Dixon T.C., et al. Anthrax. New Engl. J. Med. 341:1999;815-826.
8. Aziz M.A., et al. Expression of protective antigen in transgenic plants: a step towards edible vaccine against anthrax. Biochem. Biophys. Res. Commun. 299:2002;345-351.