An in vitro study to investigate the use of a breath-actuated, small-volume, pneumatic nebulizer for the delivery of methacholine chloride bronchoprovocation agent

Respiratory Care

Volumn 48, Issue 1, 2003, Pages 46-51

  Mitchell, Jolyon P ^a,b   Nagel, Mark W ^a   Bates, Sara Lou ^a   Doyle, Cathy C ^a  

^a TRUDELL MEDICAL INTERNATIONAL   (Canada)

^b Medical Aerosol Laboratory   (Canada)

Author keywords

AeroEclipse; Aerosol; Bronchoprovocation; Dosimeter; Methacholine chloride; Nebulizer

Indexed keywords

METHACHOLINE CHLORIDE; BRONCHOCONSTRICTING AGENT; DIAGNOSTIC AGENT;

AEROSOL; ARTICLE; BREATHING; BREATHING APPARATUS; BRONCHUS; CORRELATION ANALYSIS; DRUG DELIVERY SYSTEM; IN VITRO STUDY; LASER DIFFRACTION; NEBULIZATION; NEBULIZER; PROVOCATION TEST; ADULT; DISPOSABLE EQUIPMENT; EQUIPMENT DESIGN; HUMAN; INHALATION TEST; INSTRUMENTATION; PARTICLE SIZE;

ADULT; AEROSOLS; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; DISPOSABLE EQUIPMENT; EQUIPMENT DESIGN; HUMANS; METHACHOLINE CHLORIDE; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE;

EID: 0037844956     PISSN: 00201324     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Scott GC, Braun SR. A survey of the current use and methods of analysis of bronchoprovocational challenges. Chest 1991;100(2):322-328.
2. Sterk PJ, Fabbri LM, Quanjer PH, Cockcroft DW, O'Byrne PM, Anderson SD, et al. [Airway response. Standardized provocation tests in adults: pharmacological, physical and sensitizing stimuli. Work Group on Standardization of Respiratory Function Tests. European Community for Coal and Steel. Official position of the European Respiratory Society] Rev Mal Respir 1994;11 Suppl 3:53-83. Article in French.
3. Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000;161(1):309-329.
4. American Association for Respiratory Care. AARC Clinical Practice Guideline: Methacholine challenge testing: 2001 revision & update. Respir Care 2001;46(5):523-530.
5. Loffert DT, Ikle D, Nelson HS. A comparison of commercial jet nebulizers. Chest 1994;106(6):1788-1792.
6. Alvine GF, Rodgers P, Fitzsimmons KM, Ahrens RC. Disposable jet nebulizers: how reliable are they? Chest 1992;101(2):316-319.
7. Nieminen MM, Holli H, Lahdensuo A, Muittari A, Karvonen J. Aerosol deposition in automatic dosimeter nebulizer. Eur J Respir Dis 1987;71(3):145-152.
8. Ward RJ, Ward C, Johns DP, Skoric B, Abramson M, Walters EH. European Community Respiratory Health Survey calibration project of dosimeter driving pressures. Eur Respir J 2002;19(2):252-256.
9. Hayes RD, Beach JR, Rutherford DM, Sim MR. Stability of methacholine chloride solutions under different storage conditions over a 9 month period. Eur Respir J 1998;11(4):946-948.
10. Nagel MW, Doyle CC, Bates, SL, Mitchell JP. An in vitro investigation of common nebulizer dosing protocols, comparing a breath-actuated with conventional pneumatic small volume nebulizer (SVN). In: Dalby RN, Byron PR, Peart J, Farr SJ, editors. Respiratory drug delivery VIII. Raleigh NC: Davis Horwood International Publishing Ltd; 2002:627-629.
11. European Standard EN 13544-1. Respiratory therapy equipment. Part 1. Nebulizing systems and their components. European Committee for Standardization; Brussels, Belgium. 2001.
12. Clark AR. The use of laser diffraction for the evaluation of the aerosol clouds generated by medical nebulizers. Int J Pharm 1995;115:69-78.
13. Zanen P, Go LT, Lammers JJ. The optimal particle size for β adrenergic aerosols in mild asthmatics. Int J Pharm 1994;107:211-217.
14. Ryan G, Dolovich MB, Obminski G, Cockcroft DW, Juniper E, Hargreave FE, Newhouse MT. Standardization of inhalation provocation tests: influence of nebulizer output, particle size, and method of inhalation. J Allergy Clin Immunol 1981;67(2):156-161.
15. Boe J, Dennis JH, O'Driscoll BR, Bauer TT, Carone M, Dautzenberg B, et al. European Respiratory Society Guidelines on the use of nebulizers. Eur Respir J 2001;18(1);228-242.
16. Finlay WH. The mechanics of inhaled pharmaceutical aerosols. London: Academic Press; 2001:175-220.
17. Cockcroft DW, Marciniuk DD, Hurst TS, Cotton DJ, Laframboise KF, McNab BD, Skomro RP. Methacholine challenge: test shortening procedures. Chest 2001;120(6):1857-1860.