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Volumn 3, Issue 2, 2003, Pages 93-109

Pegylated interferon plus ribavirin for the treatment of chronic hepatitis C

Author keywords

Chronic hepatitis C; Peginterferon alfa 2a; Peginterferon alfa 2b; Pegylated interferon; Ribavirin

Indexed keywords

AMANTADINE; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN;

EID: 0037840261     PISSN: 1533001X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (46)

References (35)
  • 1
    • 0036091729 scopus 로고    scopus 로고
    • Management issues in chronic viral hepatitis: Hepatitis C
    • Sievert W. Management issues in chronic viral hepatitis: hepatitis C. J Gastroenterol Hepatol. 2002;17:415-422.
    • (2002) J. Gastroenterol. Hepatol. , vol.17 , pp. 415-422
    • Sievert, W.1
  • 2
    • 0038366142 scopus 로고    scopus 로고
    • Consensus Development Conference Statement: Management of Hepatitis C: 2002
    • National Institutes of Health NIH Consensus Development Program; June 10-12, 2002; Bethesda, MD; 19(1). Available at Accessed November 25
    • National Institutes of Health. Consensus Development Conference Statement: Management of Hepatitis C: 2002. NIH Consensus Development Program; June 10-12, 2002; Bethesda, MD; 19(1). Available at: http://consensus.nih.gov/cons/116/116cdc_intro.htm. Accessed November 25, 2002.
    • (2002)
  • 3
    • 0036105759 scopus 로고    scopus 로고
    • Management of viral hepatitis C
    • Leung NW. Management of viral hepatitis C. J Gastroenterol Hepatol. 2002; 17(suppl):S146-S154.
    • (2002) J. Gastroenterol. Hepatol. , vol.17 , Issue.SUPPL.
    • Leung, N.W.1
  • 4
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med. 2002;347:975-982.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 5
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet. 2001;358:958-965.
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 6
    • 0037690100 scopus 로고    scopus 로고
    • Pegasys® [package insert]. Nutley, NJ: Hoffman-La Roche Inc; October
    • Pegasys® [package insert]. Nutley, NJ: Hoffman-La Roche Inc; October 2002.
    • (2002)
  • 7
    • 0038027996 scopus 로고    scopus 로고
    • PEG-Intron® [package insert]. Kenilworth, NJ: Schering-Plough Corporation; July
    • PEG-Intron® [package insert]. Kenilworth, NJ: Schering-Plough Corporation; July 2002.
    • (2002)
  • 8
    • 0037690099 scopus 로고    scopus 로고
    • Copegus™ [package insert]. Nutley, NJ: Hoffman-La Roche Inc; December
    • Copegus™ [package insert]. Nutley, NJ: Hoffman-La Roche Inc; December 2002.
    • (2002)
  • 9
    • 0026124772 scopus 로고
    • The therapeutic value of poly(ethylene glycol)-modified proteins
    • Nucci ML, Short R, Abuchowski A. The therapeutic value of poly(ethylene glycol)-modified proteins. Adv Drug Deliv Rev. 1991;6(2):133-151.
    • (1991) Adv. Drug Deliv. Rev. , vol.6 , Issue.2 , pp. 133-151
    • Nucci, M.L.1    Short, R.2    Abuchowski, A.3
  • 11
    • 0027253357 scopus 로고
    • The conjugation of proteins with polyethylene glycol and other polymers: Altering properties of proteins to enhance their therapeutic potential
    • Katre NV. The conjugation of proteins with polyethylene glycol and other polymers: altering properties of proteins to enhance their therapeutic potential. Adv Drug Deliv Rev. 1993;10(1):91-114.
    • (1993) Adv. Drug Deliv. Rev. , vol.10 , Issue.1 , pp. 91-114
    • Katre, N.V.1
  • 12
    • 0001299981 scopus 로고    scopus 로고
    • A branched methoxy 40 KDA polyethylene glycol (PEG) moiety optimizes the pharmacokinetics (PK) of pegINF a-2a (PEGASYS) and may explain its enhanced efficacy in chronic hepatitis C (CHC)
    • [abstract] 4
    • Algranati NE, Sy S, Modi M. A branched methoxy 40 KDA polyethylene glycol (PEG) moiety optimizes the pharmacokinetics (PK) of pegINF a-2a (PEGASYS) and may explain its enhanced efficacy in chronic hepatitis C (CHC) [abstract]. Hepatology. 1999;30(4 pt 2):120.
    • (1999) Hepatology , vol.30 , Issue.PART 2 , pp. 120
    • Algranati, N.E.1    Sy, S.2    Modi, M.3
  • 13
    • 0035858379 scopus 로고    scopus 로고
    • Improvements in protein PEGylation: Pegylated interferons for treatment of hepatitis C
    • Kozlowski A, Harris JM. Improvements in protein PEGylation: pegylated interferons for treatment of hepatitis C. J Control Release. 2001;72:217-224.
    • (2001) J. Control Release , vol.72 , pp. 217-224
    • Kozlowski, A.1    Harris, J.M.2
  • 14
    • 0036750664 scopus 로고    scopus 로고
    • Pegylated interferons for the treatment of chronic hepatitis C infection
    • Luxon BA, Grace M, Brassard D, Bordens R. Pegylated interferons for the treatment of chronic hepatitis C infection. Clin Ther. 2002;24:1363-1383.
    • (2002) Clin. Ther. , vol.24 , pp. 1363-1383
    • Luxon, B.A.1    Grace, M.2    Brassard, D.3    Bordens, R.4
  • 15
    • 0038704421 scopus 로고    scopus 로고
    • Immunomodulatory properties of pegylated interferons: The 40KD pegylated IFN alfa 2a has greater TH1 stimulatory activity than the 12KD pegylated IFN alfa 2b
    • Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, Madrid, Spain. Abstract 136
    • Platis D, Germain C, Lombardi G, Foster G. Immunomodulatory properties of pegylated interferons: the 40KD pegylated IFN alfa 2a has greater TH1 stimulatory activity than the 12KD pegylated IFN alfa 2b. Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, 2002; Madrid, Spain. Abstract 136.
    • (2002)
    • Platis, D.1    Germain, C.2    Lombardi, G.3    Foster, G.4
  • 16
    • 0037690104 scopus 로고    scopus 로고
    • Rebetol® [package insert]. Kenilworth, NJ: Schering-Plough Corporation; September
    • Rebetol® [package insert]. Kenilworth, NJ: Schering-Plough Corporation; September 2002.
    • (2002)
  • 17
    • 0034324083 scopus 로고    scopus 로고
    • Pegylated interferon-alpha-2b: Pharmacokinetics, pharmacodynamics, safety, and preliminary efficacy data
    • Glue P, Fang JW, Rouzier-Panis R, et al. Pegylated interferon-alpha-2b: pharmacokinetics, pharmacodynamics, safety, and preliminary efficacy data. Clin Pharmacol Ther. 2000;68:556-567.
    • (2000) Clin. Pharmacol. Ther. , vol.68 , pp. 556-567
    • Glue, P.1    Fang, J.W.2    Rouzier-Panis, R.3
  • 18
    • 0033844251 scopus 로고    scopus 로고
    • A dose-ranging study of pegylated interferon alfa-2b and ribavirin in chronic hepatitis C
    • The Hepatitis C Intervention Therapy Group
    • Glue P, Rouzier-Panis R, Raffanel C, et al. A dose-ranging study of pegylated interferon alfa-2b and ribavirin in chronic hepatitis C. The Hepatitis C Intervention Therapy Group. Hepatology. 2000;32:647-653.
    • (2000) Hepatology , vol.32 , pp. 647-653
    • Glue, P.1    Rouzier-Panis, R.2    Raffanel, C.3
  • 19
    • 0034619946 scopus 로고    scopus 로고
    • Peginterferon alfa-2a in patients with chronic hepatitis C
    • Zeuzem S, Feinman SV, Rasenack J, et al. Peginterferon alfa-2a in patients with chronic hepatitis C. N Engl J Med. 2000;343:1666-1672.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1666-1672
    • Zeuzem, S.1    Feinman, S.V.2    Rasenack, J.3
  • 20
    • 0034619980 scopus 로고    scopus 로고
    • Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis
    • Heathcote EJ, Shiffman ML, Cooksley WG, et al. Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis. N Engl J Med. 2000;343:1673-1680.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1673-1680
    • Heathcote, E.J.1    Shiffman, M.L.2    Cooksley, W.G.3
  • 21
    • 0242424675 scopus 로고    scopus 로고
    • Peginterferon alfa-2a (40kd) in combination with ribavirin (RBV): Efficacy and safety results from a phase III, randomized, double-blind, multicentre study examining effect of duration of treatment and the RBV dose
    • Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, Madrid, Spain. Abstract 536
    • Hadziyannis SJ, Cheinquer H, Morgan T, et al. Peginterferon alfa-2a (40kd) in combination with ribavirin (RBV): efficacy and safety results from a phase III, randomized, double-blind, multicentre study examining effect of duration of treatment and the RBV dose. Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, 2002; Madrid, Spain. Abstract 536.
    • (2002)
    • Hadziyannis, S.J.1    Cheinquer, H.2    Morgan, T.3
  • 22
    • 0038028001 scopus 로고    scopus 로고
    • Pegasys plus ribavirin produces highest sustained virological response (SVR) rate ever achieved for patients with HCV genotype 1. Hepatitis C News Stories
    • [HIV and Hepatitis.com Web site]. April 18, 2002. Available at: www.hivandhepatitis.com/hepnews/041902a.html. Accessed December 12
    • Baker R. Pegasys plus ribavirin produces highest sustained virological response (SVR) rate ever achieved for patients with HCV genotype 1. Hepatitis C News Stories. [HIV and Hepatitis.com Web site]. April 18, 2002. Available at: www.hivandhepatitis.com/hepnews/041902a.html. Accessed December 12, 2002.
    • (2002)
    • Baker, R.1
  • 23
    • 0038366143 scopus 로고    scopus 로고
    • HBeAg-positive chronic hepatitis B (CHB) patients with difficult-to-treat disease: Improved response rates with peginterferon alfa-2a (40KD) (PEGASYS®) compared with conventional interferon alfa-2a
    • Abstract presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases; November 1-5, Boston, MA Abstract 846 2002
    • Cooksley WG, Lai M, Piratvisuth T, et al. HBeAg-positive chronic hepatitis B (CHB) patients with difficult-to-treat disease: improved response rates with peginterferon alfa-2a (40KD) (PEGASYS®) compared with conventional interferon alfa-2a. Abstract presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases; November 1-5, 2002; Boston, MA. Hepatology. 2002;36(4). Abstract 846.
    • (2002) Hepatology , vol.36 , pp. 4
    • Cooksley, W.G.1    Lai, M.2    Piratvisuth, T.3
  • 24
    • 0038704426 scopus 로고    scopus 로고
    • Ditto-HCV early viral kinetics report: Novel decline patterns in gen 1 but not gen 2-3 patients treated with peg-interferon-alfa-2a and ribavirin
    • Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, Madrid, Spain. Abstract 565
    • Neumann AU, Zeuzem S, Ferrari C, et al. Ditto-HCV early viral kinetics report: novel decline patterns in gen 1 but not gen 2-3 patients treated with peg-interferon-alfa-2a and ribavirin. Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, 2002; Madrid, Spain. Abstract 565.
    • (2002)
    • Neumann, A.U.1    Zeuzem, S.2    Ferrari, C.3
  • 25
    • 0038704424 scopus 로고    scopus 로고
    • Viral kinetics of combination pegylated interferon a-2A and ribavirin in patients with hepatitis C cirrhosis
    • Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, Madrid, Spain. Abstract 5301
    • Gane E, Chapman B, Holland J, et al. Viral kinetics of combination pegylated interferon a-2A and ribavirin in patients with hepatitis C cirrhosis. Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, 2002; Madrid, Spain. Abstract 5301.
    • (2002)
    • Gane, E.1    Chapman, B.2    Holland, J.3
  • 26
    • 0038704425 scopus 로고    scopus 로고
    • Prospective evaluation of early virologic response associated with peginterferon alfa-2a (40KD) (PEGASYS®) and ribavirin from a phase IV, randomized study examining the effects of treatment duration in hepatitis C patients infected with genotype 1
    • Abstract presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases; November 1-5, Boston, MA. Abstract 101915
    • Brandao CE, Perez-Gomez R, Pessoa MG, et al. Prospective evaluation of early virologic response associated with peginterferon alfa-2a (40KD) (PEGASYS®) and ribavirin from a phase IV, randomized study examining the effects of treatment duration in hepatitis C patients infected with genotype 1. Abstract presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases; November 1-5, 2002; Boston, MA. Abstract 101915.
    • (2002)
    • Brandao, C.E.1    Perez-Gomez, R.2    Pessoa, M.G.3
  • 27
    • 0038027994 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) dynamics during therapy with peginterferon alfa-2a (40KD) (PEGASYS®) compared to peginterferon alfa-2b (12KD) (PEG-Intron®) in naïve patients with chronic hepatitis C (CHC)
    • Abstract presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases; November 1-5, 2002; Boston, MA. Abstract 102172 4 Abstract 159
    • Bruno R, Debiaggi M, Ciappina V, et al. Hepatitis C virus (HCV) dynamics during therapy with peginterferon alfa-2a (40KD) (PEGASYS®) compared to peginterferon alfa-2b (12KD) (PEG-Intron® in naïve patients with chronic hepatitis C (CHC). Abstract presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases; November 1-5, 2002; Boston, MA. Abstract 102172. Hepatology. 2002;36(4 pt 2). Abstract 159.
    • (2002) Hepatology , vol.36 , Issue.PART 2
    • Bruno, R.1    Debiaggi, M.2    Ciappina, V.3
  • 28
    • 0001584467 scopus 로고    scopus 로고
    • Pegylated interferon alfa-2a (Pegasys™) and ribavirin combination therapy for chronic hepatitis C: A phase II open-label study
    • [abstract] 4
    • Sulkowski MS, Reindollar R, Yu J. Pegylated interferon alfa-2a (Pegasys™) and ribavirin combination therapy for chronic hepatitis C: a phase II open-label study [abstract]. Gastroenterology. 2000;118(4 suppl 2):236.
    • (2000) Gastroenterology , vol.118 , Issue.SUPPL. 2 , pp. 236
    • Sulkowski, M.S.1    Reindollar, R.2    Yu, J.3
  • 29
    • 0000030258 scopus 로고    scopus 로고
    • Combination therapy with peginterferon alfa-2a (PEG-IFN) and ribavirin in the treatment of patients with chronic hepatitis C (CHC): A phase II open-label study
    • [abstract] 4 Abstract 145
    • Sulkowski MS, Reindollar R, Yu J. Combination therapy with peginterferon alfa-2a (PEG-IFN) and ribavirin in the treatment of patients with chronic hepatitis C (CHC): a phase II open-label study [abstract]. Hepatology. 1999;30(4 pt 2):197A. Abstract 145.
    • (1999) Hepatology , vol.30 , Issue.PART 2
    • Sulkowski, M.S.1    Reindollar, R.2    Yu, J.3
  • 30
    • 0038704423 scopus 로고    scopus 로고
    • Peginterferon alfa-2a (40KD) (PEGASYS®) plus ribavirin in chronic hepatitis C: Retreatment of patients who relapsed virologically after 24 weeks of therapy
    • Abstract presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases; November 1-5, 2002; Boston, MA. Abstract 102870 4 Abstract 794
    • Goncales F, Bernstein DE, Berg C, et al. Peginterferon alfa-2a (40KD) (PEGASYS®) plus ribavirin in chronic hepatitis C: retreatment of patients who relapsed virologically after 24 weeks of therapy. Abstract presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases; November 1-5, 2002; Boston, MA. Abstract 102870. Hepatology. 2002;36(4 pt 2). Abstract 794.
    • (2002) Hepatology , vol.36 , Issue.PART 2
    • Goncales, F.1    Bernstein, D.E.2    Berg, C.3
  • 31
    • 0037690102 scopus 로고    scopus 로고
    • Efficacy and safety of peginterferon alfa-2a (PEGASYS®) combination therapies in patients with chronic hepatitis C (CHC) who relapsed on interferon alfa-2b plus ribavirin (REBETRON®) therapy
    • Abstract presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases; November 1-5, Boston, MA. Abstract 100934
    • Herrine SK, Brown R, Esposito S, et al. Efficacy and safety of peginterferon alfa-2a (PEGASYS®) combination therapies in patients with chronic hepatitis C (CHC) who relapsed on interferon alfa-2b plus ribavirin (REBETRON®) therapy. Abstract presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases; November 1-5, 2002; Boston, MA. Abstract 100934.
    • (2002)
    • Herrine, S.K.1    Brown, R.2    Esposito, S.3
  • 32
    • 0001400951 scopus 로고    scopus 로고
    • Pegylated (40KDA) interferon alfa-2a (Pegasys™) in new combination therapies: A preliminary report of a randomized, multicenter efficacy and safety study
    • [abstract] 4 Abstract 1139
    • Di Bisceglie AM, Bernstein DE, Rustgi VR, et al. Pegylated (40KDA) interferon alfa-2a (Pegasys™) in new combination therapies: a preliminary report of a randomized, multicenter efficacy and safety study [abstract]. Hepatology. 2000;43(4 pt 2):444A. Abstract 1139.
    • (2000) Hepatology , vol.43 , Issue.PART 2
    • Di Bisceglie, A.M.1    Bernstein, D.E.2    Rustgi, V.R.3
  • 33
    • 0038366144 scopus 로고    scopus 로고
    • Pegylated 40KDA IFN a-2a plus amantadine (AMA) or ribavirin (RBV) in naïves with chronic hepatitis C (CHC): The HIMPCT (Hepatitis Italian Multicenter Pegasys Amantadine Cooperative trial)
    • Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, Madrid, Spain. Abstract 209
    • Ideo G, Angelico M, Chirianni A, et al. Pegylated 40KDA IFN a-2a plus amantadine (AMA) or ribavirin (RBV) in naïves with chronic hepatitis C (CHC): the HIMPCT (Hepatitis Italian Multicenter Pegasys Amantadine Cooperative trial). Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, 2002; Madrid, Spain. Abstract 209.
    • (2002)
    • Ideo, G.1    Angelico, M.2    Chirianni, A.3
  • 34
    • 0038366145 scopus 로고    scopus 로고
    • A 3-arm randomized study evaluating the efficacy of triple therapy of pegylated or recombinant interferon alpha-2a 3 MU both combined with ribavirin and amantadine versus dual therapy of recombinant interferon alpha-2a plus ribavirin in naïve patients with chronic HCV hepatitis
    • Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, Madrid, Spain. Abstract 185
    • Mangia A, Ricci G, Minerva N, et al. A 3-arm randomized study evaluating the efficacy of triple therapy of pegylated or recombinant interferon alpha-2a 3 MU both combined with ribavirin and amantadine versus dual therapy of recombinant interferon alpha-2a plus ribavirin in naïve patients with chronic HCV hepatitis. Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, 2002; Madrid, Spain. Abstract 185.
    • (2002)
    • Mangia, A.1    Ricci, G.2    Minerva, N.3
  • 35
    • 4243347541 scopus 로고    scopus 로고
    • Two doses of peg-interferon alfa 2b plus ribavirin in genotype 1 naïve patients with chronic hepatitis
    • Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, Madrid, Spain. Abstract 655
    • Buti M, Lurie Y, Sanchez F, et al. Two doses of peg-interferon alfa 2b plus ribavirin in genotype 1 naïve patients with chronic hepatitis. Abstract presented at: 37th Annual Meeting of the European Association for the Study of Liver; April 18-21, 2002; Madrid, Spain. Abstract 655.
    • (2002)
    • Buti, M.1    Lurie, Y.2    Sanchez, F.3


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