Noma: An "infectious" disease of unknown aetiology

Lancet Infectious Diseases

Volumn 3, Issue 7, 2003, Pages 419-431

  Baratti Mayer, Denise ^a   Pittet, Brigitte ^c   Montandon, Denys ^c   Bolivar, Ignacio ^c   Bornand, Jacques Etienne ^c   Hugonnet, Stéphane ^c   Jaquinet, Alexandre ^b   Schrenzel, Jacques ^c   Pittet, Didier ^b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ASCORBIC ACID; PENICILLIN G; SULFONAMIDE;

ACUTE DISEASE; AFRICA; ANTIBIOTIC THERAPY; BACTERIUM; CLINICAL FEATURE; DEVELOPING COUNTRY; GINGIVA DISEASE; HUMAN; IMMUNE DEFICIENCY; INFECTION; MALNUTRITION; MORBIDITY; MORTALITY; MOUTH HYGIENE; PATHOPHYSIOLOGY; PLASTIC SURGERY; PRIORITY JOURNAL; REVIEW; STOMATITIS;

EID: 0037821706     PISSN: 14733099     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1473-3099(03)00670-4     Document Type: Review

References (119)

1. Bourgeois DM, Leclercq MH. The World Health Organization initiative on noma. Oral Dis 1999; 5: 172-74.
2. Adekeye EO, Ord RA. Cancrum oris: principles of management and reconstructive surgery. J Maxillofac Surg 1983; 11: 160-70.
3. Tourdes J. Du noma ou du sphacèle de la bouche chez les enfants. Strasbourg: Faculté de Médecine de Strasbourg, 1848.
4. Hicken NF, Eldredge RB. Acute myelogenous leukemia complicated by noma and acute streptococcic dermatitis. Am J Dis Child 1935; 50: 1455-64.
5. Seifert E. Zur Krankheitsauffassung der Noma und gleichartiger Formen des Gewbsbrandes. Zentralbl Chir 1938; 34.
6. Eckstein A. Noma. Am J Dis Child 1940; 59: 219-37.
7. Dawson J. Cancrum oris. Br Dent J 1945; 79: 11-17.
8. Adelsberger L. Medical observations in Auschwitz concentration camp. Lancet 1946; 1: 317-19.
9. Weinstein RA, Choukas NC, Wood WS. Cancrum oris-like lesion associated with acute myelogenous leukemia. Oral Surg Oral Med Oral Pathol 1974; 38: 10-14.
10. Limongelli WA, Clark MS, Williams AC. Nomalike lesion in a patient with chronic lymphocytic leukemia: review of the literature and report of a case. Oral Surg Oral Med Oral Pathol 1976; 41: 40-51.
11. Bendl BJ, Padmos A, Harder EJ, McArthur PD. Noma: report of three adult cases. Australas J Dermatol 1983; 24: 115-21.
12. Stassen LF, Batchelor AG, Rennie JS, Moos KF. Cancrum oris in an adult Caucasian female. Br J Oral Maxillofac Surg 1989; 27: 417-22.
13. Longo G, Vanzanelli P, Bevini M, et al. Noma in paziente con leucemia acuta allergica alla penicillina. Recenti Prog Med 1993; 84: 272-75.
14. Akula SK, Creticos CM, Weldon-Linne CM. Gangrenous stomatitis in AIDS. Lancet 1989; 1: 955.
15. Giovannini M, Zuccotti GV, Fiocchi A. Gangrenous stomatitis in a child with AIDS. Lancet 1989; 2: 1400.
16. Darie H, Cautoclaud A, Lajaunie C, Millet P. Aspects dermatologiques du SIDA en Afrique de l'Ouest: à propos de 140 observations. Bull Soc Pathol Exot 1994; 87: 176-80.
17. Barrios TJ, Aria AA, Brahney C. Cancrum oris in an HIV-positive patient. J Oral Maxillofac Surg 1995; 53: 851-55.
18. Chidzonga MM. Noma (cancrum oris) in human immunodeficiency virus/acquired immune deficiency syndrome patients: report of eight cases. J Oral Maxillofac Surg 1996; 54: 1056-60.
19. Ghosal SP, Sen Gupta PC, Mukherjee AK, Choudhury M, Dutta N, Sarkar AK. Noma neonatorum: its aetiopathogenesis. Lancet 1978; 2: 289-91.
20. Borle RM, Agrawal M. Noma neonatorum. Int J Oral Maxillofac Surg 1987; 16: 626-29.
21. Lin JY, Wang DW, Peng CT, Tsai FJ, Chiou YM, Tsai CH. Noma neonatorum: an unusual case of noma involving a full-term neonate. Acta Paediatr 1992; 81: 720-22.
22. Barmes DE, Enwonwu CO, Leclercq MH, Bourgeois D, Falkler WA. The need for action against oro-facial gangrene (noma). Trop Med Int Health 1997; 2: 1111-14.
23. Sheiham A. The epidemiology of chronic periodontal disease in Western Nigerian schoolchildren. J Periodontal Res 1968; 3: 257-67.
24. Idigbe EO, Enwonwu CO, Falkler WA, et al. Living conditions of children at risk for noma: Nigerian experience. Oral Dis 1999; 5: 156-62.
25. Bourgeois DM, Diallo B, Frieh C, Leclercq MH. Epidemiology of the incidence of oro-facial noma: a study of cases in Dakar, Senegal, 1981-1993. Am J Trop Med Hyg 1999; 61: 909-13.
26. Adolph HP, Yugueros P, Woods JE. Noma: a review. Ann Plast Surg 1996; 37: 657-68.
27. Tempest MN. Cancrum oris. Br J Surg 1966; 53: 949-69.
28. Boulnois, Rabedaoro. Le noma de Madagascar. Sém Hôp Paris 1950; 26: 517-28.
29. Jelliffe DB. Infective gangrene of the mouth (cancrum oris). Pediatrics 1952; 9: 544-50.
30. Oginni FO, Oginni AO, Ugboko VI, Otuyemi OD. A survey of cases of cancrum oris seen in Ile-Ife, Nigeria. Int J Paediatr Dent 1999; 9: 75-80.
31. Sawyer DR, Nwoku AL. Cancrum oris (noma): past and present. ASDC J Dent Child 1981; 48: 138-41.
32. Pindborg JJ, Bhat M, Devanath KR, Narayana HR, Ramachandra S. Occurrence of acute necrotizing gingivitis in South Indian children. J Periodontol 1966; 37: 14-19.
33. Emslie RD. Cancrum oris. Dent Pract 1963; 13: 481-95.
34. Enwonwu CO. Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma (cancrum oris) in Nigerian children. Arch Oral Biol 1972; 17: 1357-71.
35. Menezes DM, Orth D. The etiology and effects of cancrum oris in children. ASDC J Dent Child 1976; 43: 92-95.
36. Horning GM. Necrotizing gingivostomatitis: NUG to noma. Compend Contin Educ Dent 1996; 17: 951-54.
37. Contreras A, Falkler WA Jr, Enwonwu CO, et al. Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria. Oral Microbiol Immunol 1997; 12: 259-65.
38. Contreras A, Slots J. Active cytomegalovirus infection in human periodontitis. Oral Microbiol Immunol 1998; 13: 225-30.
39. Falkler WA Jr, Enwonwu CO, Idigbe EO. Microbiological understandings and mysteries of noma (cancrum oris). Oral Dis 1999; 5: 150-55.
40. Goldhaber P, Giddon DB. Present concepts concerning the etiology and treatment of acute necrotizing ulcerative gingivitis. Int Dent J 1964; 14: 468-96.
41. Barnes GP, Bowles WFr, Carter HG. Acute necrotizing ulcerative gingivitis: a survey of 218 cases. J Periodontol 1973; 44: 35-42.
42. Loesche WJ, Syed SA, Laughon BE, Stoll J. The bacteriology of acute necrotizing ulcerative gingivitis. J Periodontol 1982; 53: 223-30.
43. Melnick SL, Roseman JM, Engel D, Cogen RB. Epidemiology of acute necrotizing ulcerative gingivitis. Epidemiol Rev 1988; 10: 191-211.
44. Glick M, Muzyka BC, Salkin LM, Lurie D. Necrotizing ulcerative periodontitis: a marker for immune deterioration and a predictor for the diagnosis of AIDS. J Periodontol 1994; 65: 393-97.
45. Holmstrup P, Westergaard J. Necrotizing periodontal disease. In: Lindhe J, ed. Clinical periodontology and implant dentistry, 3 edn. Oxford: Blackwell, 1997: 258-78.
46. Arendorf TM, Bredekamp B, Cloete CA, Joshipura K. Seasonal variation of acute necrotising ulcerative gingivitis in South Africans. Oral Dis 2001; 7: 150-54.
47. Malberger E. Acute infectious oral necrosis among young children in the Gambia, West-Africa. J Periodontal Res 1967; 2: 154-62.
48. Ndiaye FC, Bourgeois D, Leclercq MH, Berthe O. Noma: public health problem in Senegal and epidemiological surveillance. Oral Dis 1999; 5: 163-66.
49. Agnew RG. Cancrum oris. J Periodont 1947; 18: 22-33.
50. Enwonwu CO. Noma: a neglected scourge of children in sub-Saharan Africa. Bull World Health Organ 1995; 73: 541-45.
51. Dijkstra R, Abate-Green C, Yoo MC. Noma. Eur J Plast Surg 1986; 9: 46-51.
52. Montandon D, Lehmann C, Chami N. The surgical treatment of noma. Plast Reconstr Surg 1991; 87: 76-86.
53. Adams-Ray WE, James JH. Cancrum oris: functional and cosmetic reconstruction in patients with ankylosis of the jaws. Br J Plast Surg 1992; 45: 193-98.
54. Ginisty D, Piral T, Adamsbaum C, Camara A, Rak-Merkin H. Les constrictions permanentes des mâchoires de l'enfant: trois cas d'étiologie extra-articulaire. Rev Stomatol Chir Maxillofac 1996; 97: 47-52.
55. Marck KW, de Bruijn HP. Surgical treatment of noma. Oral Dis 1999; 5: 167-71.
56. Pittet B, Jaquinet A, Montandon D. Clinical experience in the treatment of noma sequelae. J Craniofac Surg 2001; 12: 273-83.
57. Enwonwu CO, Falkler WA Jr, Idigbe EO, Savage KO. Noma (cancrum oris): questions and answers. Oral Dis 1999; 5: 144-49.
58. Chandra RK. Inducer and suppressor T cell subsets in protein-energy malnutrition: analysis by monoclonal antibodies. Nutr Res 1982; 2: 21-26.
59. Beisel WR. Nutrition in pediatric HIV infection: setting the research agenda. J Nutr 1996; 126 (suppl): 2611-15.
60. Chandra RK. Numerical and functional deficiency in T helper cells in protein energy malnutrition. Clin Exp Immunol 1983; 51: 126-32.
61. Chandra RK. Nutrition and immunity: lessons from the past and new insights into the future. Am J Clin Nutr 1991; 53: 1087-101.
62. Seymour GJ, Crouch MS, Powell RN, et al. The identification of lymphoid cell subpopulations in sections of human lymphoid tissue and gingivitis in children using monoclonal antibodies. J Periodontal Res 1982; 17: 247-56.
63. Alleyne GAO, Hay RW, Picou DI, Stanfield JP, Whitehead RG. Protein-energy malnutrition. London: Edward Arnold, 1977: 54-103.
64. Cogen RB, Stevens AW Jr, Cohen-Cole S, Kirk K, Freeman A. Leukocyte function in the etiology of acute necrotizing ulcerative gingivitis. J Periodontol 1983; 54: 402-07.
65. Beisel WR. Historical overview of nutrition and immunity, with emphasis on vitamin A. J Nutr Immunol 1996; 4: 1-16.
66. Doulas NL, Constantopoulos A, Litsios B. Effect of ascorbic acid on guinea pig adrenal adenylate cyclase activity and plasma cortisol. J Nutr 1987; 117: 1108-14.
67. Enwonwu CO, Sawiris P, Chanaud N. Effect of marginal ascorbic acid deficiency on saliva level of cortisol in the guinea pig. Arch Oral Biol 1995; 40: 737-42.
68. Chandra RK, Au B. Single nutrient deficiency and cell-mediated immune responses: I, zinc. Am J Clin Nutr 1980; 33: 736-38.
69. Mason JB, Rosenberg IH. Protein-energy malnutrition. In: Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL, eds. Harrison's principles of internal medicine. New York: McGraw-Hill, 1994: 440-46.
70. Gould BS. Biology of collagen. In: Ramachandran GN, ed. Treatise on collagen. London: Academic Press, 1968: 139-88.
71. Bowness JM, Harding G. Increase in serum hyaluronidase levels in rats given hydrocortisone or prednisolone. Can J Biochem 1968; 46: 489-95.
72. Irving JT. Factors concerning bone loss associated with periodontal disease. J Dent Res 1970; 49: 262-67.
73. Selye H. Effects of cortisone and somatotrophic hormone upon the development of a noma-like condition in the rat. Oral Surg 1953; 6: 557-61.
74. Kornman KS, Loesche WJ. Effects of estradiol and progesterone on Bacteroides melaninogenicus and Bacteroides gingivalis. Infect Immun 1982; 35: 256-63.
75. Enwonwu CO, Falkler WA Jr, Idigbe EO, et al. Pathogenesis of cancrum oris (noma): confounding interactions of malnutrition with infection. Am J Trop Med Hyg 1999; 60: 223-32.
76. Sawyer DR, Nwoku AL, Rotimi VO, Hagen JC. Comparison of oral microflora between well-nourished and malnourished Nigerian children. ASDC J Dent Child 1986; 53: 439-43.
77. Costini B, Larroque G, Duboscq JC, Montandon D. Noma ou cancrum oris: aspects étiopathogéniques et nosologiques. Med Trop (Mars) 1995; 55: 263-73.
78. Pindborg JJ, Bhat M, Roed-Petersen B. Oral changes in South Indian children with severe protein deficiency. J Periodontol 1967; 38: 218-21.
79. Sawyer DR, Nwoku AL. Malnutrition and the oral health of children in Ogbomosho, Nigeria. ASDC J Dent Child 1985; 52: 141-45.
80. Osuji OO. Necrotizing ulcerative gingivitis and cancrum oris (noma) in Ibadan, Nigeria. J Periodontol 1990; 61: 769-72.
81. Taiwo JO. Oral hygiene status and necrotizing ulcerative gingivitis in Nigerian children. J Periodontol 1993; 64: 1071-74.
82. Weaver GH. Noma. J Infect Dis 1907; 4: 8-36.
83. Salmi AA. Suppression of T-cell immunity after measles infection: is the puzzle solved? Trends Microbiol 1997; 5: 85-86.
84. Bhaskaram P. Measles and malnutrition. Indian J Med Res 1995; 102: 195-99.
85. Kozminska-Kubarska A, Talleyrand D, Bakatubia M. Cutaneous complications during measles in Zairian children: noma-like postmeasles ulcerations. Int J Dermatol 1982; 21: 465-69.
86. Neumann J, Ranke MB. Noma. Monatsschr Kinderheilkd 1983; 131: 528-31.
87. Abramson JS, Wheeler JG. Virus-induced neutrophil dysfunction: role in the pathogenesis of bacterial infections. Pediatr Infect Dis J 1994; 13: 643-52.
88. Salonen R, Ilonen J, Salmi AA. Measles virus inhibits lymphocyte proliferation in vitro by two different mechanisms. Clin Exp Immunol 1989; 75: 376-80.
89. Karp CL, Wysocka M, Wahl LM, et al. Mechanism of suppression of cell-mediated immunity by measles virus. Science 1996; 273: 228-31.
90. Laine D, Valentin H, Servet-Delprat C, Vidalain P-O, Zaffran Y, Rabourdin-Combe C. Infection par le virus de la rougeole: modèle d'une immunosuppression généralisée viro-induite. Virologie 2002; 6: 353-61.
91. Mamadou S, Kaka M, Montavon C, et al. A propos d'une association VIH et noma au Niger. Bull Soc Pathol Exot 2002; 95: 76-77.
92. Reynaud J, Garand G, Ployet MJ, Robier A. Du noma au syndrome de Silvermann: une pathogénie à discuter. Ann Chir Plast 1978; 23: 227-30.
93. Ellouz M, Adouani A, Seghir M. A propos d'une maladie africaine: le noma. Ann Chir Plast Esthet 1989; 34: 334-38.
94. Falkler WA Jr, Enwonwu CO, Idigbe EO. Isolation of Fusobacterium necrophorum from cancrum oris (noma). Am J Trop Med Hyg 1999; 60: 150-56.
95. Enwonwu CO, Falkler WA, Idigbe EO. Oro-facial gangrene (noma/cancrum oris): pathogenetic mechanisms. Crit Rev Oral Biol Med 2000; 11: 159-71.
96. Falkler WA, Enwonwu CO, Ewell AJ, Idigbe EO. Isolation of fusobacteria from the oral cavities of malnourished Nigerian children living in agricultural and herding villages. Oral Dis 2000; 6: 103-05.
97. Langendijk PS, Schut F, Jansen GJ, et al. Quantitative fluorescence in situ hybridization of Bifidobacterium spp with genus-specific 16S rRNA-targeted probes and its application in fecal samples. Appl Environ Microbiol 1995; 61: 3069-75.
98. Paster BJ, Boches SK, Galvin JL, et al. Bacterial diversity in human subgingival plaque. J Bacteriol 2001; 183: 3770-83.
99. Kroes I, Lepp PW, Relman DA. Bacterial diversity within the human subgingival crevice. Proc Natl Acad Sci USA 1999; 96: 14547-52.
100. Paster BJ, Falkler WAJ, Enwonwu CO, et al. Prevalent bacterial species and novel phylotypes in advanced noma lesions. J Clin Microbiol 2002; 40: 2187-91.
101. Paster BJ, Bartoszyk IM, Dewhirst FE. Identification of oral streptococci using PCR-based, reverse-capture, checkerboard hybridization. Methods Cell Sci 1998; 20: 223-31.
102. Anthony RM, Brown TJ, French GL. Rapid diagnosis of bacteremia by universal amplification of 23S ribosomal DNA followed by hybridization to an oligonucleotide array. J Clin Microbiol 2000; 38: 781-88.
103. Small J, Call DR, Brockman FJ, Straub TM, Chandler DP. Direct detection of 16S rRNA in soil extracts by using oligonucleotide microarrays. Appl Environ Microbiol 2001; 67: 4708-16.
104. Wang RF, Beggs ML, Robertson LH, Cerniglia CE. Design and evaluation of oligonucleotide-microarray method for the detection of human intestinal bacteria in fecal samples. FEMS Microbiol Lett 2002; 213: 175-82.
105. Sabiston CB Jr. A review and proposal for the etiology of acute necrotizing gingivitis. J Clin Periodontol 1986; 13: 727-34.
106. Contreras A, Slots J. Herpesviruses in human periodontal disease. J Periodontal Res 2000; 35: 3-16.
107. Slots J, Contreras A. Herpesviruses: a unifying causative factor in periodontitis? Oral Microbiol Immunol 2000; 15: 277-80.
108. Rubin RH, Cosimi AB, Tolkoff-Rubin NE, Russell PS, Hirsch MS. Infectious disease syndromes attributable to cytomegalovirus and their significance among renal transplant recipients. Transplantation 1977; 24: 458-64.
109. Ten Napel CHH. Acute cytomegalovirus infection and the host immune response: I, development and maintenance of cytomegalovirus (CMV) induced in vitro lymphocyte reactivity and its relationship to the production of CMV antibodies. Clin Exp Immunol 1980; 39: 263-71.
110. Ten Napel CHH, The TH. Acute cytomegalovirus infection and the host immune response: II, relationship of suppressed in vitro lymphocyte reactivity to bacterial recall antigens and mitogens with the development of cytomegalovirus-induced lymphocyte reactivity. Clin Exp Immunol 1980; 39: 272-78.
111. Iwamoto GK, Monick MM, Clark BD, Auron PE, Stinski MF, Hunninghake GW. Modulation of interleukin 1 beta gene expression by the immediate early genes of human cytomegalovirus. J Clin Invest 1990; 85: 1853-57.
112. Stashenko P, Fujiyoshi P, Obernesser MS, Prostak L, Haffajee AD, Socransky SS. Levels of interleukin 1 beta in tissue from sites of active periodontal disease. J Clin Periodontol 1991; 18: 548-54.
113. Ting M, Contreras A, Slots I. Herpesvirus in localized juvenile periodontitis. J Periodontal Res 2000; 35: 17-25.
114. Wouters SLJ, Van Campen GJ, Mikx FHM, Van der Hoeven JS. Experimental induced ANUG in Beagle dogs. J Dental Res 1977; 56 (suppl A): 46 (abstr 13).
115. WHO. Le noma, une maladie qui ne devrait pas exister. Noma contact 1997; October: 1-8.
116. Tassonyi E, Lehmann C, Gunning K, Coquoz E, Montandon D. Fiberoptically guided intubation in children with gangrenous stomatitis (noma). Anesthesiology 1990; 73: 348-49.
117. Pittet B, Montandon D. Nasal reconstruction in children: a review of 29 patients. J Craniofac Surg 1998; 9: 522-28.
118. Montandon D, Pittet B. Reconstruction labiale dans les séquelles de noma. Ann Chir Plast Esthet 2002; 47: 520-35.
119. Oluwasanmi JO, Lagundoye SB, Akinyemi OO. Ankylosis of the mandible from cancrum oris. Plast Reconstr Surg 1976; 57: 342-50.