Synthesis of 6-substituted imidazo[4,5-d]pyridazin-7-ones

Heterocycles

Volumn 60, Issue 6, 2003, Pages 1329-1337

  Gilligan, Paul J ^a   Bakthavatchalam, Rajagopal ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b Neurogen Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2,4 DICHLOROPHENYL) 2 ETHYL 1 (1 ETHYLPROPYL) 6 METHYLIMIDAZO[4,5 D]PYRIDAZIN 7 ONE; 4 (2,4 DICHLOROPHENYL) 2 ETHYL 1 (1 ETHYLPROPYL) 6 PROPYLIMIDAZO[4,5 D]PYRIDAZIN 7 ONE; 4 (2,4 DICHLOROPHENYL) 2 ETHYL 6 METHYL 1 (1 METHYLBUTYL)IMIDAZO[4,5 D]PYRIDAZIN 7 ONE; 4 (2,4 DICHLOROPHENYL) 2,6 DIETHYL 1 (1 ETHYLPROPYL)IMIDAZO[4,5 D]PYRIDAZIN 7 ONE; 4 (2,4 DITRIFLUOROMETHYLPHENYL) 2 ETHYL 1 (1 ETHYLPROPYL) 6 METHYLIMIDAZO[4,5 D]PYRIDAZIN 7 ONE; 4 (2,5 DIMETHYL 4 METHOXYPHENYL) 2 ETHYL 6 METHYL 1 (1 METHYLBUTYL)IMIDAZO[4,5 D]PYRIDAZIN 7 ONE; 6 (N CYCLOPROPYLMETHYL) 4 (2,4 DICHLOROPHENYL) 2 ETHYL 1 (1 ETHYLPROPYL)IMIDAZO[4,5 D]PYRIDAZIN 7 ONE; CORTICOTROPIN RELEASING FACTOR RECEPTOR; IMIDAZO[4,5 D]PYRIDAZIN 7 ONE DERIVATIVE; IMIDAZO[4,5 D]PYRIDAZINE DERIVATIVE; N,N DIMETHYLFORMAMIDE; PYRIDAZINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0037809413     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-03-9731     Document Type: Article

References (9)

1. Bristol-Myers Squibb Co., Discovery Chemistry, 5 Research Parkway, Wallingford, CT 06492.
2. Neurogen Inc., 35 N.E. Industrial Rd., Branford, CT 06405.
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5. Related studies have been presented previously. P.J. Gilligan and R. Bakthavatchalam, Book of Abstracts, 221st National Meeting of the American Chemical Society, San Diego, CA, April 1-5, 2001; American Chemical Society: Washington, DC, MEDI 101.
6. M.P. Groziak and L. Wei, J. Org. Chem., 1992, 57, 3776.
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8. E.B. Desouza, Neuroscience, 1987, 7, 88.
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