-
1
-
-
0030983708
-
Mortalitiy by cause for eight regions of the world; global burden of disease study
-
MURRAY CJ, LOPEZ AD: Mortalitiy by cause for eight regions of the world; global burden of disease study. Lancet (1997) 349:1269-1276.
-
(1997)
Lancet
, vol.349
, pp. 1269-1276
-
-
Murray, C.J.1
Lopez, A.D.2
-
2
-
-
0037065502
-
Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
-
ANTITHROMBOTIC TRIALISTS' COLLABORATION
-
ANTITHROMBOTIC TRIALISTS' COLLABORATION: Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Br. Med. J. (2002) 324:71-86.
-
(2002)
Br. Med. J.
, vol.324
, pp. 71-86
-
-
-
3
-
-
0034268673
-
Oral platelet glycoprotein IIb/IIIa inhibition
-
NEWBY LK, MCGUIRE DK: Oral platelet glycoprotein IIb/IIIa inhibition. Curr. Cardiol. Rep. (2000) 2:372-377.
-
(2000)
Curr. Cardiol. Rep.
, vol.2
, pp. 372-377
-
-
Newby, L.K.1
McGuire, D.K.2
-
4
-
-
0036286524
-
Optimizing prophylaxis of venous thromboembolism
-
TURPIE AG: Optimizing prophylaxis of venous thromboembolism. Semin. Thromb. Hemost. (2002) 28(Suppl. 2):25-32.
-
(2002)
Semin. Thromb. Hemost.
, vol.28
, Issue.SUPPL. 2
, pp. 25-32
-
-
Turpie, A.G.1
-
5
-
-
0026337077
-
The coagulation cascade: Initiation, maintenance, and regulation
-
DAVIE EW, FUJIKAWA K, KISIEL W: The coagulation cascade: initiation, maintenance, and regulation. Biochemistry (1991) 30:10363-10370.
-
(1991)
Biochemistry
, vol.30
, pp. 10363-10370
-
-
Davie, E.W.1
Fujikawa, K.2
Kisiel, W.3
-
6
-
-
0034759373
-
Human thrombi contain an abundance of active thrombin
-
MUTCH NJ, ROBBIE LA, BOOTH NA: Human thrombi contain an abundance of active thrombin. Thromb. Haemost. (2001) 86:1028-1034.
-
(2001)
Thromb. Haemost.
, vol.86
, pp. 1028-1034
-
-
Mutch, N.J.1
Robbie, L.A.2
Booth, N.A.3
-
7
-
-
0037235550
-
Anticoagulation in management of atrial fibrillation
-
EZEKOWITZ MD, NETREBKO PI: Anticoagulation in management of atrial fibrillation. Curr. Opin. Cardiol. (2003) 18:26-31.
-
(2003)
Curr. Opin. Cardiol.
, vol.18
, pp. 26-31
-
-
Ezekowitz, M.D.1
Netrebko, P.I.2
-
8
-
-
0027216868
-
Structural and functional characterization of tick anticoagulant peptide (TAP): A potent and selective inhibitor of blood coagulation Factor Xa
-
VLASUK GP: Structural and functional characterization of tick anticoagulant peptide (TAP): a potent and selective inhibitor of blood coagulation Factor Xa. Thromb. Haemost. (1993) 70:212-216.
-
(1993)
Thromb. Haemost.
, vol.70
, pp. 212-216
-
-
Vlasuk, G.P.1
-
10
-
-
85044705869
-
Oral delivery of heparin in combination with sodium N-(8[2-hydroxybenzoyl]amino)caprylate: Pharmacologic considerations
-
RIVERA TM: Oral delivery of heparin in combination with sodium N-(8[2-hydroxybenzoyl]amino)caprylate: pharmacologic considerations. Pharm. Res. (1997) 14:1830-1834.
-
(1997)
Pharm. Res.
, vol.14
, pp. 1830-1834
-
-
Rivera, T.M.1
-
11
-
-
0036690723
-
Pathway of oral absorption of heparin with sodium N-[8-(2-hydroxybenzoyl)amino] caprylate
-
MALKOV D, WANG HZ, DINH S, GOMEZ-ORELLANA I: Pathway of oral absorption of heparin with sodium N-[8-(2-hydroxybenzoyl)amino] caprylate. Pharm. Res. (2002) 19:1180-1184.
-
(2002)
Pharm. Res.
, vol.19
, pp. 1180-1184
-
-
Malkov, D.1
Wang, H.Z.2
Dinh, S.3
Gomez-Orellana, I.4
-
13
-
-
0034612268
-
Orally administered unfractionated heparin with carrier agent is therapeutic for deep venous thrombosis
-
GONZE MD, SALARTASH K, STERNBERGH WC 3rd, BAUGHMAN RA, LEONE-BAY A, MONEY SR: Orally administered unfractionated heparin with carrier agent is therapeutic for deep venous thrombosis. Circulation (2000) 101:2658-2661.
-
(2000)
Circulation
, vol.101
, pp. 2658-2661
-
-
Gonze, M.D.1
Salartash, K.2
Sternbergh W.C. III3
Baughman, R.A.4
Leone-Bay, A.5
Money, S.R.6
-
14
-
-
0035971113
-
Hypersulfated low molecular weight heparin with reduced affinity for antithrombin acts as an anticoagulant by inhibiting intrinsic tenase and prothrombinase
-
ANDERSON JA, FREDENBURGH JC, STAFFORD AR et al.: Hypersulfated low molecular weight heparin with reduced affinity for antithrombin acts as an anticoagulant by inhibiting intrinsic tenase and prothrombinase. J. Biol. Chem. (2001) 276:9755-9761.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9755-9761
-
-
Anderson, J.A.1
Fredenburgh, J.C.2
Stafford, A.R.3
-
15
-
-
0036811777
-
Antithrombin-independent anticoagulation by hypersulfated low-molecular-weight heparin
-
FREDENBURGH JC, ANDERSON JA, WEITZ JI: Antithrombin-independent anticoagulation by hypersulfated low-molecular-weight heparin. Trends Cardiovasc. Med. (2002) 12:281-287.
-
(2002)
Trends Cardiovasc. Med.
, vol.12
, pp. 281-287
-
-
Fredenburgh, J.C.1
Anderson, J.A.2
Weitz, J.I.3
-
16
-
-
0037457893
-
Rational design of low-molecular-weight hepatitis with improved in vivo activity
-
SUNDARAM M, QI Y, SHRIVER Z, LIU D et al.: Rational design of low-molecular-weight hepatitis with improved in vivo activity. Proc. Natl. Acad. Sci. USA (2003) 100:651-656.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 651-656
-
-
Sundaram, M.1
Qi, Y.2
Shriver, Z.3
Liu, D.4
-
17
-
-
0021061174
-
Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity
-
CHOAY J, PETITOU M, LORMEAU JC, SINAY P, CASU B, GATTI G: Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity. Biochem. Biophys. Res. Commun. (1983) 116:492-499.
-
(1983)
Biochem. Biophys. Res. Commun.
, vol.116
, pp. 492-499
-
-
Choay, J.1
Petitou, M.2
Lormeau, J.C.3
Sinay, P.4
Casu, B.5
Gatti, G.6
-
18
-
-
0035522302
-
Fondaparinux compared with Enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery
-
ERIKSSON BI, BAUER KA, LASSEN MR et al.: Fondaparinux compared with Enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N. Engl. J. Med. (2001) 345:1298-1304.
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1298-1304
-
-
Eriksson, B.I.1
Bauer, K.A.2
Lassen, M.R.3
-
19
-
-
0037129720
-
Postoperative fondaparinux versus postoperative enoxaparin for the prevention of venous thromboembolism after elective hip-replacemetn surgery: A randomised double-blind trial
-
TURPIE AGG, BAUER KA, ERIKSSON BJ et al.: Postoperative fondaparinux versus postoperative enoxaparin for the prevention of venous thromboembolism after elective hip-replacemetn surgery: a randomised double-blind trial. Lancet (2002) 359:1721-1726.
-
(2002)
Lancet
, vol.359
, pp. 1721-1726
-
-
Turpie, A.G.G.1
Bauer, K.A.2
Eriksson, B.J.3
-
20
-
-
0034727707
-
Treatment of proximal deep vein thrombosis with a novel synthetic compound (SR90107A/ORG31540) with pure anti-factor Xa activity
-
THE REMBRANDT INVESTIGATORS
-
THE REMBRANDT INVESTIGATORS: Treatment of proximal deep vein thrombosis with a novel synthetic compound (SR90107A/ORG31540) with pure anti-factor Xa activity. Circulation (2000) 102:2726-2731.
-
(2000)
Circulation
, vol.102
, pp. 2726-2731
-
-
-
21
-
-
0034925569
-
New data in treatment of acute coronary syndromes
-
VAN DE WERF F: New data in treatment of acute coronary syndromes. Am. Heart J. (2001) 142(Suppl. 2):S16-S21.
-
(2001)
Am. Heart J.
, vol.142
, Issue.SUPPL. 2
-
-
Van De Werf, F.1
-
22
-
-
0036283477
-
Selective inhibition of coagulation factors: Advances in antithrombotic therapy
-
BAUER KA: Selective inhibition of coagulation factors: advances in antithrombotic therapy. Semin. Thromb. Hemost. (2002) 28(Suppl. 2):15-24.
-
(2002)
Semin. Thromb. Hemost.
, vol.28
, Issue.SUPPL. 2
, pp. 15-24
-
-
Bauer, K.A.1
-
23
-
-
0036195867
-
Fondaparinux: A synthetic heparin pentasaccharide as a new antithrombotic agent
-
WALENGA JM, JESKE WP, FRAPAISE FX, BICK RL, FAREED J, SAMAMA MM: Fondaparinux: a synthetic heparin pentasaccharide as a new antithrombotic agent. Expert Opin. Investig. Drugs (2002) 11:397-407.
-
(2002)
Expert Opin. Investig. Drugs
, vol.11
, pp. 397-407
-
-
Walenga, J.M.1
Jeske, W.P.2
Frapaise, F.X.3
Bick, R.L.4
Fareed, J.5
Samama, M.M.6
-
24
-
-
2642617786
-
Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting synthetic pentasaccharide
-
HERBERT JM, HERAULT JP, BERNAT A et al.: Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting synthetic pentasaccharide. Blood (1998) 91:4197-4205.
-
(1998)
Blood
, vol.91
, pp. 4197-4205
-
-
Herbert, J.M.1
Herault, J.P.2
Bernat, A.3
-
25
-
-
0037279367
-
Idraparinux and liver enzymes: Observations from the PERSIST trial
-
REITER M, BUCEK RA, KOCA N, HEGER J, MINAR E: Idraparinux and liver enzymes: observations from the PERSIST trial. Blood Coagul. Fibrinolysis (2003) 14:61-65.
-
(2003)
Blood Coagul. Fibrinolysis
, vol.14
, pp. 61-65
-
-
Reiter, M.1
Bucek, R.A.2
Koca, N.3
Heger, J.4
Minar, E.5
-
26
-
-
0036281553
-
Pharmacokinetics of new synthetic heparin mimetics
-
HERAULT JP, BERNAT A, ROYE F et al.: Pharmacokinetics of new synthetic heparin mimetics. Thromb. Haemost. (2002) 87:985-989.
-
(2002)
Thromb. Haemost.
, vol.87
, pp. 985-989
-
-
Herault, J.P.1
Bernat, A.2
Roye, F.3
-
27
-
-
0036173279
-
Effect of new synthetic heparin mimetics on whole blood thrombin generation in vivo and in vitro in rats
-
HERAULT JP, BERNAT A, GAICH C, HERBERT M: Effect of new synthetic heparin mimetics on whole blood thrombin generation in vivo and in vitro in rats. Thromb. Haemost. (2002) 87:238-244.
-
(2002)
Thromb. Haemost.
, vol.87
, pp. 238-244
-
-
Herault, J.P.1
Bernat, A.2
Gaich, C.3
Herbert, M.4
-
28
-
-
0033920237
-
Recent advances in clinical trials of the direct and indirect selective Factor Xa inhibitors
-
PORCARI AR, CHI L, LEADLEY R: Recent advances in clinical trials of the direct and indirect selective Factor Xa inhibitors. Expert Opin. Investig. Drugs (2000) 9:1595-1600.
-
(2000)
Expert Opin. Investig. Drugs
, vol.9
, pp. 1595-1600
-
-
Porcari, A.R.1
Chi, L.2
Leadley, R.3
-
29
-
-
0030097984
-
DX 9065a a novel, synthetic, selective and orally active inhibitor of Factor Xa: In vitro and in vivo studies
-
HERBERT JM, BERNAT A, DOL F, HERAULT JP, CREPON B, LORMEAU JC: DX 9065a a novel, synthetic, selective and orally active inhibitor of Factor Xa: in vitro and in vivo studies. J. Pharmacol. Exp. Ther. (1996) 276:1030-1038.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.276
, pp. 1030-1038
-
-
Herbert, J.M.1
Bernat, A.2
Dol, F.3
Herault, J.P.4
Crepon, B.5
Lormeau, J.C.6
-
30
-
-
0033623976
-
Pharmacokinetics of the anticoagulant 14C-DX-9065a in the healthy male volunteer after a single intravenous dose
-
MURAYAMA N, MCMAHON H, YOUNG CG et al.: Pharmacokinetics of the anticoagulant 14C-DX-9065a in the healthy male volunteer after a single intravenous dose. Xenobiotica (2000) 30:515-521.
-
(2000)
Xenobiotica
, vol.30
, pp. 515-521
-
-
Murayama, N.1
McMahon, H.2
Young, C.G.3
-
31
-
-
12444297069
-
DX-9065a, a novel direct Factor Xa antagonist stimulates release of tissue factor pathway inhibitor (TFPI) from human vascular endothelial cells
-
(Abstract)
-
BECKER RC, YOUFU L, ALEXANDER JH, SPENCER F, ROBERTSON TL, KUNITADA S: DX-9065a, a novel direct Factor Xa antagonist stimulates release of tissue factor pathway inhibitor (TFPI) from human vascular endothelial cells. Circulation (2002) (Suppl. II):337 (Abstract).
-
(2002)
Circulation
, Issue.SUPPL. II
, pp. 337
-
-
Becker, R.C.1
Youfu, L.2
Alexander, J.H.3
Spencer, F.4
Robertson, T.L.5
Kunitada, S.6
-
32
-
-
0036847576
-
Antithrombotic effects of DX-9065a, a direct Factor Xa inhibitor a comparative study in humans versus low molecular weight heparin
-
SHIMBO D, OSENDE J, CHEN J et al.: Antithrombotic effects of DX-9065a, a direct Factor Xa inhibitor a comparative study in humans versus low molecular weight heparin. Thromb. Haemost. (2002) 88:733-738.
-
(2002)
Thromb. Haemost.
, vol.88
, pp. 733-738
-
-
Shimbo, D.1
Osende, J.2
Chen, J.3
-
33
-
-
0037150191
-
First experience with direct Factor Xa inhibition in patients with stable coronary disease: A pharmacokinetic and pharmacodynamic evaluation
-
DYKE CK, BECKER RC, KLEIMAN NS et al.: First experience with direct Factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation. Circulation (2002) 105:2385-2391.
-
(2002)
Circulation
, vol.105
, pp. 2385-2391
-
-
Dyke, C.K.1
Becker, R.C.2
Kleiman, N.S.3
-
34
-
-
0035865785
-
Discovery of 1-[3-(aminomethyl phenyl]-N-3-fluoro-2′-(methylsulfonyl)- [1,1′biphenyl]-4-yl]-3-(trifluoromathyl)-1 pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation Factor Xa
-
PINTO DJ, ORWAT MJ, WANG S et al.: Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2′-(methylsulfonyl)- [1,1′biphenyl]-4-yl]-3-(trifluoromathyl)-1 pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation Factor Xa. J. Med. Chem. (2001) 44:566-578.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 566-578
-
-
Pinto, D.J.1
Orwat, M.J.2
Wang, S.3
-
35
-
-
0036387145
-
Nonpeptide Factor Xa inhibitors: DPC423, a highly potent an orally bioavailable pyrazole antithrombotic agent
-
WONG PC, PINTO DJ, KNABB RM: Nonpeptide Factor Xa inhibitors: DPC423, a highly potent an orally bioavailable pyrazole antithrombotic agent. Cardiovasc. Drug Rev. (2002) 20:137-152.
-
(2002)
Cardiovasc. Drug Rev.
, vol.20
, pp. 137-152
-
-
Wong, P.C.1
Pinto, D.J.2
Knabb, R.M.3
-
36
-
-
0036897444
-
Nonpeptide Factor Xa inhibitors III: Effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits
-
WONG PC, CRAIN EJ, WATSON CA et al.: Nonpeptide Factor Xa inhibitors III: Effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits. J. Pharmacol. Exp. Ther. (2002) 303:993-1000.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 993-1000
-
-
Wong, P.C.1
Crain, E.J.2
Watson, C.A.3
-
37
-
-
0035880858
-
Pharmacological characterization of a novel Factor Xa inhibitor FXV673
-
CHU V, BROWN K, COLUSSI D et al.: Pharmacological characterization of a novel Factor Xa inhibitor FXV673. Thromb. Res. (2001) 103:309-324.
-
(2001)
Thromb. Res.
, vol.103
, pp. 309-324
-
-
Chu, V.1
Brown, K.2
Colussi, D.3
-
38
-
-
0037124202
-
Optimization of the beta-aminoester class of Factor Xa inhibitors. Identification of FXV673 as a potent and selective inhibitor with excellent in vivo anticoagulant activity
-
GUERTIN KR, GARDNER CJ, KLEIN SI et al.: Optimization of the beta-aminoester class of Factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent in vivo anticoagulant activity Bioorg. Med. Chem. Lett. (2002) 12:1671-1674.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, Issue.PART 2
, pp. 1671-1674
-
-
Guertin, K.R.1
Gardner, C.J.2
Klein, S.I.3
-
39
-
-
0034887402
-
Antithrombotic efficacy of a novel Factor Xa inhibitor, FXV6 in a canine model of coronary artery thrombolysis
-
REBELLO SS, BENTLEY RG, MORGAN SR et al.: Antithrombotic efficacy of a novel Factor Xa inhibitor, FXV6 in a canine model of coronary artery thrombolysis. Br. J. Pharmacol. (2001) 133:1190-1198.
-
(2001)
Br. J. Pharmacol.
, vol.133
, pp. 1190-1198
-
-
Rebello, S.S.1
Bentley, R.G.2
Morgan, S.R.3
-
40
-
-
12444282255
-
-
IDDB meeting report from the 17th International Society of Thrombosis and Haemostasis Congress 1999, Washington DC, USA. IDdb3 Report (338793)
-
AHMED T: IDDB meeting report from the 17th International Society of Thrombosis and Haemostasis Congress 1999, Washington DC, USA. IDdb3 Report (1999) (338793).
-
(1999)
-
-
Ahmed, T.1
-
41
-
-
0033947739
-
In vitro characterization of a novel Factor Xa inhibitor, RPR 130737
-
CHU V, BROWN K, COLUSSI D et al.: In vitro characterization of a novel Factor Xa inhibitor, RPR 130737. Thromb. Res. (2000) 99:71-82.
-
(2000)
Thromb. Res.
, vol.99
, pp. 71-82
-
-
Chu, V.1
Brown, K.2
Colussi, D.3
-
42
-
-
0035383215
-
Discovery of the Factor Xa inhibitor, ZK 807834 (CI-1031)
-
LIGHT DR, GUILFORD WJ: Discovery of the Factor Xa inhibitor, ZK 807834 (CI-1031). Curr. Top. Med. Chem. (2001) 1:121-136.
-
(2001)
Curr. Top. Med. Chem.
, vol.1
, pp. 121-136
-
-
Light, D.R.1
Guilford, W.J.2
-
43
-
-
18244397236
-
Assessment of ex vivo pharmacodynamic markers during inhibition of thrombosis by CI-1031 (ZK-807834), a novel direct Factor Xa inhibitor
-
CHI L, PEN YW, POTOCZAK R et al.: Assessment of ex vivo pharmacodynamic markers during inhibition of thrombosis by CI-1031 (ZK-807834), a novel direct Factor Xa inhibitor. Pharmacology (2002) 64:76-83.
-
(2002)
Pharmacology
, vol.64
, pp. 76-83
-
-
Chi, L.1
Pen, Y.W.2
Potoczak, R.3
-
44
-
-
0037082373
-
Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031)
-
POST JM, SULLIVAN ME, ABENDSCHEIN D, EWING J, HINCHMAN JW, LIGL DR: Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031). Thromb. Res. (2002) 105:347-352.
-
(2002)
Thromb. Res.
, vol.105
, pp. 347-352
-
-
Post, J.M.1
Sullivan, M.E.2
Abendschein, D.3
Ewing, J.4
Hinchman, J.W.5
Ligl, D.R.6
-
45
-
-
0033810831
-
Nonpeptide Factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis
-
WONG PC, CRAIN EJ, KNABB RM et al.: Nonpeptide Factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis. J. Pharmacol. Exp. Ther. (2000) 295:212-218.
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 212-218
-
-
Wong, P.C.1
Crain, E.J.2
Knabb, R.M.3
-
46
-
-
0033957888
-
Nonpeptide Factor Xa inhibitors: I. Studies with SF303 and SK549, a new class of potent antithrombotics
-
WONG PC, QUAN ML, CRAIN EJ, WATSON CA, WEXLER RR, KNABB RM: Nonpeptide Factor Xa inhibitors: I. Studies with SF303 and SK549, a new class of potent antithrombotics. J. Pharmacol. Exp. Ther. (2000) 292:351-357.
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.292
, pp. 351-357
-
-
Wong, P.C.1
Quan, M.L.2
Crain, E.J.3
Watson, C.A.4
Wexler, R.R.5
Knabb, R.M.6
-
47
-
-
18744386088
-
A novel family of anticoagulants from the saliva of Ixodes scapularis
-
NARASIMHAN S, KOSKI RA, BEAULIEU B et al.: A novel family of anticoagulants from the saliva of Ixodes scapularis. Insect Mol. Biol. (2002) 11:641-650.
-
(2002)
Insect Mol. Biol.
, vol.11
, pp. 641-650
-
-
Narasimhan, S.1
Koski, R.A.2
Beaulieu, B.3
-
48
-
-
19044367143
-
Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as a Factor Xa inhibitor II. Substituent effect on biological activities
-
NISHIDA H, MIYAZAKI Y, MUKAIHIRA T et al.: Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as a Factor Xa inhibitor II. Substituent effect on biological activities. Chem. Pharm. Bull. (2002) 50:1187-1194.
-
(2002)
Chem. Pharm. Bull.
, vol.50
, pp. 1187-1194
-
-
Nishida, H.1
Miyazaki, Y.2
Mukaihira, T.3
-
49
-
-
18344374666
-
The discovery of YM-60828: A potent, selective and orally-bioavailable Factor Xa inhibitor
-
HIRAYAMA F, KOSHIO H, KATAYAMA N et al.: The discovery of YM-60828: a potent, selective and orally-bioavailable Factor Xa inhibitor. Bioorg. Med. Chem. (2002) 10:1509-1523.
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 1509-1523
-
-
Hirayama, F.1
Koshio, H.2
Katayama, N.3
-
50
-
-
0034675818
-
Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P1-ketoamide moieties
-
SEMPLE JE, LEVY OE, MINAMI NK, OWENS TD, SIEV DV: Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P1-ketoamide moieties. Bioorg. Med. Chem. Lett. (2000) 10:2305-2309.
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 2305-2309
-
-
Semple, J.E.1
Levy, O.E.2
Minami, N.K.3
Owens, T.D.4
Siev, D.V.5
-
51
-
-
0035910359
-
Antithrombotic effects of a synthetic inhibitor of activated Factor X, JTV-803, in animals
-
HAYASHI M, MATSUO A, NAKAMOTO H, AISAKA K: Antithrombotic effects of a synthetic inhibitor of activated Factor X, JTV-803, in animals. Eur. J. Pharmacol. (2001) 412:61-66.
-
(2001)
Eur. J. Pharmacol.
, vol.412
, pp. 61-66
-
-
Hayashi, M.1
Matsuo, A.2
Nakamoto, H.3
Aisaka, K.4
-
52
-
-
12444308887
-
-
IDDB meeting report from the XIVth Annual World Congress of Pharmacology; July 2002, San Francisco, USA. IDdb3 Report (457377)
-
WATERWORTH C: IDDB meeting report from the XIVth Annual World Congress of Pharmacology; July 2002, San Francisco, USA. IDdb3 Report (2002) (457377).
-
(2002)
-
-
Waterworth, C.1
-
53
-
-
0003190426
-
New drugs in the R&D pipeline
-
The IDdb reference report (460177) 1806
-
The IDdb reference report (460177): New drugs in the R&D pipeline. Pharma Japan (2002) 1806:1-20.
-
(2002)
Pharma. Japan
, pp. 1-20
-
-
-
54
-
-
0037212871
-
Design and synthesis of Factor Xa inhibitors and their prodrugs
-
SONG Y, CLIZBE L, BHAKTA C et al.: Design and synthesis of Factor Xa inhibitors and their prodrugs. Bioorg. Med Chem. Lett. (2003) 13:297-300.
-
(2003)
Bioorg. Med Chem. Lett.
, vol.13
, pp. 297-300
-
-
Song, Y.1
Clizbe, L.2
Bhakta, C.3
-
56
-
-
0026773026
-
Clinical application of the synthetic thrombin inhibitor, argatroban (MD-805)
-
MATSUO T, KARIO K, KODAMA K, OKAMOTO S: Clinical application of the synthetic thrombin inhibitor, argatroban (MD-805). Sem. Thromb. Hemost. (1992) 18:155-160.
-
(1992)
Sem. Thromb. Hemost.
, vol.18
, pp. 155-160
-
-
Matsuo, T.1
Kario, K.2
Kodama, K.3
Okamoto, S.4
-
57
-
-
0035712804
-
Pharmacokinetics of an emerging new class of anticoagulant-antithrombotic drugs. A review of small-molecule thrombin inhibitors
-
HAUPTMANN J: Pharmacokinetics of an emerging new class of anticoagulant-antithrombotic drugs. A review of small-molecule thrombin inhibitors. Eur. J. Clin. Pharmacol. (2002) 57:751-758.
-
(2002)
Eur. J. Clin. Pharmacol.
, vol.57
, pp. 751-758
-
-
Hauptmann, J.1
-
58
-
-
12244263507
-
The express study: Preliminary results
-
GLYNN O: The express study: preliminary results. Int. J. Clin. Pract. (2003) 57:57-59.
-
(2003)
Int. J. Clin. Pract.
, vol.57
, pp. 57-59
-
-
Glynn, O.1
-
59
-
-
0037048939
-
Ximelagatran and melagartan compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: The METHRO II randomised trial
-
ERIKSSON BI, BERGQVIST D, KALEBO P et al.: Ximelagatran and melagartan compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial. Lancet (2002) 360:1441-1447.
-
(2002)
Lancet
, vol.360
, pp. 1441-1447
-
-
Eriksson, B.I.1
Bergqvist, D.2
Kalebo, P.3
-
60
-
-
0037104691
-
Pharmacokinetics, pharmacodynamics and clinical effects of the oral direct thrombin inhibitor ximelagatran in acute treatment of patients with pulmonary embolism and deep vein thrombosis
-
WAHLANDER K, LAPIDUS L, OLSSON CC et al.: Pharmacokinetics, pharmacodynamics and clinical effects of the oral direct thrombin inhibitor ximelagatran in acute treatment of patients with pulmonary embolism and deep vein thrombosis. Thromb. Res. (2002) 107:93-99.
-
(2002)
Thromb. Res.
, vol.107
, pp. 93-99
-
-
Wahlander, K.1
Lapidus, L.2
Olsson, C.C.3
-
61
-
-
0041424038
-
New proline mimetics: Synthesis of thrombin inhibitors incorporating cyclopentane- and cyclopentenedicarboxylic acid templates in the P2 position
-
NOTEBERG D, BRANALT J, KVARNSTROM I et al.: New proline mimetics: synthesis of thrombin inhibitors incorporating cyclopentane- and cyclopentenedicarboxylic acid templates in the P2 position. J. Med. Chem. (2000) 43:1705-1713.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 1705-1713
-
-
Noteberg, D.1
Branalt, J.2
Kvarnstrom, I.3
-
62
-
-
0037171819
-
Structure-based design of novel potent nonpeptide thrombin inhibitors
-
HAUEL NH, NAR H, PRIEPKE H, RIES U, STASSEN JM, WIENEN W: Structure-based design of novel potent nonpeptide thrombin inhibitors. J. Med. Chem. (2002) 45:1757-1766.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1757-1766
-
-
Hauel, N.H.1
Nar, H.2
Priepke, H.3
Ries, U.4
Stassen, J.M.5
Wienen, W.6
-
63
-
-
0036628436
-
BIBR-1048 Boehringer Ingelheim
-
MUNGALL D: BIBR-1048 Boehringer Ingelheim. Curr. Opin. Investig. Drugs (2002) 3:905-907.
-
(2002)
Curr. Opin. Investig. Drugs
, vol.3
, pp. 905-907
-
-
Mungall, D.1
-
64
-
-
12444289078
-
-
IDdb meeting report from the IXth RSC-SCI Medicinal Chemistry Symposium 1997, Cambridge, UK. IDdb3 Report (263572)
-
BUCKLE DR: IDdb meeting report from the IXth RSC-SCI Medicinal Chemistry Symposium 1997, Cambridge, UK. IDdb3 Report (1997) (263572).
-
(1997)
-
-
Buckle, D.R.1
-
65
-
-
12444315571
-
New advances in a rapidly expanding blockbuster market
-
SMI Conference - Advances in Hypertension and Cardiovascular Therapeutics. IDdb3 Report (453507)
-
KAKKAR S: New advances in a rapidly expanding blockbuster market. SMI Conference - Advances in Hypertension and Cardiovascular Therapeutics. IDdb3 Report (2002) (453507).
-
(2002)
-
-
Kakkar, S.1
-
66
-
-
12444317162
-
-
3-Dimensional Pharmaceuticals, Inc. IDdb3 Report (Press release, 399111)
-
3-Dimensional Pharmaceuticals, Inc. IDdb3 Report (2001) (Press release, 399111).
-
(2001)
-
-
-
67
-
-
0035061634
-
Antithrombotic effect of LB-30057 (CI-1029), a new synthetic thrombin inhibitor, in a rabbit model of thrombosis: Comparison with inogatran
-
CHI L, MERTZ TE, ROGERS KL et al.: Antithrombotic effect of LB-30057 (CI-1029), a new synthetic thrombin inhibitor, in a rabbit model of thrombosis: comparison with inogatran. J. Thromb. Thrombolysis (2001) 11:19-31.
-
(2001)
J. Thromb. Thrombolysis
, vol.11
, pp. 19-31
-
-
Chi, L.1
Mertz, T.E.2
Rogers, K.L.3
-
68
-
-
0034526532
-
The antithrombotic effects of CI-1028, an orally bioavailable direct thrombin inhibitor, in a canine model of venous and arterial thrombosis
-
McCLANAHAN TB, HICKS GW, IGNASIAK DP et al.: The antithrombotic effects of CI-1028, an orally bioavailable direct thrombin inhibitor, in a canine model of venous and arterial thrombosis. J. Thromb. Thrombolysis (2000) 10:277-284.
-
(2000)
J. Thromb. Thrombolysis
, vol.10
, pp. 277-284
-
-
McClanahan, T.B.1
Hicks, G.W.2
Ignasiak, D.P.3
-
69
-
-
0036896159
-
SSR182289A, a novel, orally active thrombin inhibitor in vitro profile and ex vivo anticoagulant activity
-
BERRY CN, LASSALLE G, LUNVEN C et al.: SSR182289A, a novel, orally active thrombin inhibitor in vitro profile and ex vivo anticoagulant activity. J. Pharmacol. Exp. Ther. (2002) 303:1189-1198.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 1189-1198
-
-
Berry, C.N.1
Lassalle, G.2
Lunven, C.3
-
70
-
-
0034003115
-
Antithrombotic properties of RWJ-50353, a potent and novel thrombin inhibitor
-
GIARDINO EC, COSTANZO MJ, KAUFFMAN JA, LI QS, MARYANOFF BE, ANDRADE-GODRON P: Antithrombotic properties of RWJ-50353, a potent and novel thrombin inhibitor. Thromb. Res. (2000) 98:83-93.
-
(2000)
Thromb. Res.
, vol.98
, pp. 83-93
-
-
Giardino, E.C.1
Costanzo, M.J.2
Kauffman, J.A.3
Li, Q.S.4
Maryanoff, B.E.5
Andrade-Godron, P.6
-
71
-
-
0037179611
-
Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics
-
ADANG AE, DE MAN AP, VOGEL GM et al.: Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics. J. Med. Chem. (2002) 45:4419-4432.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 4419-4432
-
-
Adang, A.E.1
De Man, A.P.2
Vogel, G.M.3
-
72
-
-
12444321515
-
-
IDDB meeting report from the Cutting Edge Approaches to Drug Design - RSC's Second Meeting, London, UK, 2002. IDdb3 Report (444796)
-
NORMAN P: IDDB meeting report from the Cutting Edge Approaches to Drug Design - RSC's Second Meeting, London, UK, 2002. IDdb3 Report (2002) (444796).
-
(2002)
-
-
Norman, P.1
-
73
-
-
19244378454
-
Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl-trans-4-aminocyclohexylmethyl amide (L-372, 460: Coapplication of structure-based design and rapid multiple analogue synthesis on solid support
-
BRADY SF, STAUFFER KJ, LUMMA WC et al.: Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl-trans-4-aminocyclohexylmethyl amide (L-372, 460: coapplication of structure-based design and rapid multiple analogue synthesis on solid support. J. Med. Chem. (1998) 41:401-406.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 401-406
-
-
Brady, S.F.1
Stauffer, K.J.2
Lumma, W.C.3
-
74
-
-
0033523897
-
Design and synthesis of thrombin inhibitors: Analogues of MD 805 with reduced stereogenicity and improved potency
-
BRUNDISH D, BULL A. DONOVAN V et al: Design and synthesis of thrombin inhibitors: analogues of MD 805 with reduced stereogenicity and improved potency. J. Med. Chem. (1999) 42:4584-4603.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4584-4603
-
-
Brundish, D.1
Bull, A.2
Donovan, V.3
-
75
-
-
18644380683
-
Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bycyclic arginine surrogates
-
CUI JJ, ARALDI GL, REINER JE et al: Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bycyclic arginine surrogates. Bioorg. Med. Chem. Lett. (2002) 12:2925-2930.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 2925-2930
-
-
Cui, J.J.1
Araldi, G.L.2
Reiner, J.E.3
-
76
-
-
12444338423
-
-
Servier, following the XVIIIth ISTH meeting 2001, Paris, France. IDdb3 Report (Press release, 415369)
-
Servier, following the XVIIIth ISTH meeting 2001, Paris, France. IDdb3 Report (2001) (Press release, 415369).
-
(2001)
-
-
-
77
-
-
12444318172
-
-
VitaResc Biotech AG. IDdb3 Report (Press release, 417532)
-
VitaResc Biotech AG. IDdb3 Report (2001) (Press release, 417532).
-
(2001)
-
-
-
78
-
-
0033678017
-
Successful attenuation of venous thrombus growth in rabbits after the administration of a novel oral thrombin inhibitor
-
FRIEDERICH PW, KELLER TT, BIEMOND BJ et al.: Successful attenuation of venous thrombus growth in rabbits after the administration of a novel oral thrombin inhibitor. Thromb. Haemost. (2000) 84:858-864.
-
(2000)
Thromb. Haemost.
, vol.84
, pp. 858-864
-
-
Friederich, P.W.1
Keller, T.T.2
Biemond, B.J.3
-
79
-
-
12444334136
-
-
Groupe Fournier. IDdb3 Report (Company comm., 347216)
-
Groupe Fournier. IDdb3 Report (1999) (Company comm., 347216).
-
(1999)
-
-
-
80
-
-
0035321911
-
The role of tissue factor/factor VIIa in the pathophysiology of acute thrombotic formation
-
GIRARD TJ, NICHOLSON NS: The role of tissue factor/factor VIIa in the pathophysiology of acute thrombotic formation. Curr. Opin. Pharmacol. (2001) 1:159-163.
-
(2001)
Curr. Opin. Pharmacol.
, vol.1
, pp. 159-163
-
-
Girard, T.J.1
Nicholson, N.S.2
-
81
-
-
0030745177
-
Tissue factor pathway inhibitor: Potential therapeutic applications
-
BAJAJ MS, BAJAJ SP: Tissue factor pathway inhibitor: potential therapeutic applications. Thromb. Haemost. (1997) 78:471-477.
-
(1997)
Thromb. Haemost.
, vol.78
, pp. 471-477
-
-
Bajaj, M.S.1
Bajaj, S.P.2
-
82
-
-
0025149085
-
Recombinant human extrinsic pathway inhibitor. Production, isolation, and characterization of its inhibitory activity on tissue factor initiated coagulation reactions
-
PEDERSON AH, NORDFANG O, NORRIS F et al.: Recombinant human extrinsic pathway inhibitor. Production, isolation, and characterization of its inhibitory activity on tissue factor initiated coagulation reactions. J. Biol. Chem. (1990) 265:16786-16793.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 16786-16793
-
-
Pederson, A.H.1
Nordfang, O.2
Norris, F.3
-
83
-
-
0029806188
-
Antithrombotic effect of human recombinant tissue factor pathway inhibitor on endotoxin-induced intravascular coagulation in rats: Concerted effect with antithrombin
-
KAMIKUBO Y, HAMURO T, MATSUDA J et al: Antithrombotic effect of human recombinant tissue factor pathway inhibitor on endotoxin-induced intravascular coagulation in rats: concerted effect with antithrombin. Thromb. Haemost. (1996) 76:621-626.
-
(1996)
Thromb. Haemost.
, vol.76
, pp. 621-626
-
-
Kamikubo, Y.1
Hamuro, T.2
Matsuda, J.3
-
84
-
-
0033666309
-
Inhibition of tissue factor reduces thrombus formation and intimal hyperplasia after porcine coronary angioplasty
-
ROQUE M, REIS ED, FUSTER V et al.: Inhibition of tissue factor reduces thrombus formation and intimal hyperplasia after porcine coronary angioplasty. J. Am. Coll. Cardiol. (2000) 36:2303-2310.
-
(2000)
J. Am. Coll. Cardiol.
, vol.36
, pp. 2303-2310
-
-
Roque, M.1
Reis, E.D.2
Fuster, V.3
-
85
-
-
0036123295
-
Enhancing the antionagulant potency of soluble tissue factor mutants by increasing their affinity to Factor VIIa
-
YANG J, LEE GF, RIEDERER MA, KELLEY RF: Enhancing the antionagulant potency of soluble tissue factor mutants by increasing their affinity to Factor VIIa. Thromb. Haemost. (2002) 87:450-458.
-
(2002)
Thromb. Haemost.
, vol.87
, pp. 450-458
-
-
Yang, J.1
Lee, G.F.2
Riederer, M.A.3
Kelley, R.F.4
-
86
-
-
0035077129
-
Inhibition of arterial thrombosis by a soluble tissue factor mutant and active site-blocked factors IXa and Xa in the guinea pig
-
HIMBER J, REFINO CJ, BURCKLEN L, ROUX S, KIRCHHOFER D: Inhibition of arterial thrombosis by a soluble tissue factor mutant and active site-blocked factors IXa and Xa in the guinea pig. Thromb. Haemost. (2001) 85:475-481.
-
(2001)
Thromb. Haemost.
, vol.85
, pp. 475-481
-
-
Himber, J.1
Refino, C.J.2
Burcklen, L.3
Roux, S.4
Kirchhofer, D.5
-
87
-
-
12444275183
-
Humanized anti-human tissue factor antibody prevents both arterial and venous thrombosis in non-human primates
-
(Abstract)
-
KITAZAWA T, ASADA Y, KUMAGAI E et al.: Humanized anti-human tissue factor antibody prevents both arterial and venous thrombosis in non-human primates. Circulation (2002) (Suppl. II):596 (Abstract).
-
(2002)
Circulation
, Issue.SUPPL. II
, pp. 596
-
-
Kitazawa, T.1
Asada, Y.2
Kumagai, E.3
-
88
-
-
0034732235
-
Peptide exosite inhibitors of Factor VIIa as anticoagulants
-
DENNIS MS, EIGENBROT C, SKELTON NJ et al.: Peptide exosite inhibitors of Factor VIIa as anticoagulants Nature (2000) 404:465-470.
-
(2000)
Nature
, vol.404
, pp. 465-470
-
-
Dennis, M.S.1
Eigenbrot, C.2
Skelton, N.J.3
-
89
-
-
0035859911
-
Selection and characterization of a new class of peptide exosite inhibitors of coagulation Factor VIIa
-
DENNIS MS, ROBERGE M, QUAN C, LAZARUS RA: Selection and characterization of a new class of peptide exosite inhibitors of coagulation Factor VIIa. Biochemistry (2001) 40:9513-9521.
-
(2001)
Biochemistry
, vol.40
, pp. 9513-9521
-
-
Dennis, M.S.1
Roberge, M.2
Quan, C.3
Lazarus, R.A.4
-
90
-
-
0033569932
-
Inherent flexibility in a potent inhibitor of blood coagulation, recombinant nematode anticoagulant protein c2
-
DUGGAN BM, DYSON HJ, WRIGHT PE: Inherent flexibility in a potent inhibitor of blood coagulation, recombinant nematode anticoagulant protein c2. Eur. J. Biochem. (1999) 265:539-548.
-
(1999)
Eur. J. Biochem.
, vol.265
, pp. 539-548
-
-
Duggan, B.M.1
Dyson, H.J.2
Wright, P.E.3
-
91
-
-
0037135531
-
Nematode anticoagulant protein c2 reveals a site on Factor Xa that is important for macromolecular substrate binding to human prothrombinase
-
BUDDAI SK, TOULOKHONOVA L, BERGUM PW, VLASUK GP, KRISHNASWAMY S: Nematode anticoagulant protein c2 reveals a site on Factor Xa that is important for macromolecular substrate binding to human prothrombinase. J. Biol. Chem. (2002) 277:26689-26698.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26689-26698
-
-
Buddai, S.K.1
Toulokhonova, L.2
Bergum, P.W.3
Vlasuk, G.P.4
Krishnaswamy, S.5
-
92
-
-
0035800075
-
Dose-response study of recombinant Factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement
-
LEE A, AGNELLI G, BULLER H et al.: Dose-response study of recombinant Factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement. Circulation (2001) 3:74-78.
-
(2001)
Circulation
, vol.3
, pp. 74-78
-
-
Lee, A.1
Agnelli, G.2
Buller, H.3
-
93
-
-
12444276244
-
NAPc2 safe and well tolerated in a Phase IIa PTCA trial
-
CORVAS INTERNATIONAL CORP IDdb3 Report (Press release, 432360)
-
CORVAS INTERNATIONAL CORP: NAPc2 safe and well tolerated in a Phase IIa PTCA trial. IDdb3 Report (2001) (Press release, 432360).
-
(2001)
-
-
-
94
-
-
12444283271
-
Synthesis and pharmacokinetics of novel anticoagulants
-
224th American Chemical Society Conference, Boston, MA, USA
-
RAI R, KOLESNIKOV A, YOUNG WB, SHRADER WD, LIU L, ENRIQUEZ P: Synthesis and pharmacokinetics of novel anticoagulants. 224th American Chemical Society Conference, Boston, MA, USA (2000).
-
(2000)
-
-
Rai, R.1
Kolesnikov, A.2
Young, W.B.3
Shrader, W.D.4
Liu, L.5
Enriquez, P.6
-
95
-
-
12444274258
-
Antithrombotic effects of AXC4845, a newly synthezised and selective Factor VIIa inhibitor, in the rat thrombosis models
-
(Abstract)
-
TAKEHANA S, KAYAHARA T, TASHIRO K etal.: Antithrombotic effects of AXC4845, a newly synthezised and selective Factor VIIa inhibitor, in the rat thrombosis models. Thromb. Haemost. (2001) 86(Suppl.):P1393 (Abstract).
-
(2001)
Thromb. Haemost.
, vol.86
, Issue.SUPPL.
-
-
Takehana, S.1
Kayahara, T.2
Tashiro, K.3
-
96
-
-
12444291714
-
-
IDDB meeting report from the XVIIIth ISTH meeting 2001, Paris, France. IDdb Report (415130)
-
SO L: IDDB meeting report from the XVIIIth ISTH meeting 2001, Paris, France. IDdb Report (2001) (415130).
-
(2001)
-
-
So, L.1
-
97
-
-
0035169759
-
Plasminogen activator inhibitor type-1 (part one): Basic mechanisms, regulation, and role for thromboembolic disease
-
HUBER K: Plasminogen activator inhibitor type-1 (part one): basic mechanisms, regulation, and role for thromboembolic disease. J. Thromb. Thombolysis (2001) 11:183-193.
-
(2001)
J. Thromb. Thombolysis
, vol.11
, pp. 183-193
-
-
Huber, K.1
-
98
-
-
0037069779
-
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes
-
YAMADA Y, IZAWA H, ICHIHARA S et al.: Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N. Engl. J. Med. (2002) 347:1916-1923.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 1916-1923
-
-
Yamada, Y.1
Izawa, H.2
Ichihara, S.3
-
99
-
-
0029894647
-
Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity
-
CHARLTON PA, FAINT RW, BENT F et al.: Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. Thromb. Haemost. (1996) 75:808-815.
-
(1996)
Thromb. Haemost.
, vol.75
, pp. 808-815
-
-
Charlton, P.A.1
Faint, R.W.2
Bent, F.3
-
100
-
-
0035657712
-
Inactivation of plasminogen activator inhibitor-1 accelerates thrombolysis of platelet-rich thrombus in rat mesenteric arterioles
-
RUPIN A, MARTIN F, VALLEZ MO, BONHOMME E, VERBEUREN TJ: Inactivation of plasminogen activator inhibitor-1 accelerates thrombolysis of platelet-rich thrombus in rat mesenteric arterioles. Thromb. Haemost. (2001) 86:1528-1531.
-
(2001)
Thromb. Haemost.
, vol.86
, pp. 1528-1531
-
-
Rupin, A.1
Martin, F.2
Vallez, M.O.3
Bonhomme, E.4
Verbeuren, T.J.5
-
101
-
-
0032746547
-
The inhibitory effect of recombinant human soluble thrombomodulin on initiation and extension of coagulation - A comparison with other anticoagulants
-
MOHRI M, SUGIMOTO E, SATA M, ASANO T: The inhibitory effect of recombinant human soluble thrombomodulin on initiation and extension of coagulation - a comparison with other anticoagulants. Thromb. Haemost. (1999) 82:1687-1693.
-
(1999)
Thromb. Haemost.
, vol.82
, pp. 1687-1693
-
-
Mohri, M.1
Sugimoto, E.2
Sata, M.3
Asano, T.4
-
102
-
-
0035992710
-
Activated protein C: Potential therapy for severe sepsis, thrombosis, and stroke
-
GRIFFIN JH, ZLOKOVIC B, FERNANDEZ JA: Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. (2002) 39:197-205.
-
(2002)
Semin. Hematol.
, vol.39
, pp. 197-205
-
-
Griffin, J.H.1
Zlokovic, B.2
Fernandez, J.A.3
-
103
-
-
0033712641
-
Pharmacological profile of recombinant, human activated protein C (LY203638) in a canine model of coronary artery thrombosis
-
JACKSON CV, BAILEY BD, SHETLER TJ: Pharmacological profile of recombinant, human activated protein C (LY203638) in a canine model of coronary artery thrombosis. J. Pharmacol. Exp. Ther. (2000) 295:967-971.
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 967-971
-
-
Jackson, C.V.1
Bailey, B.D.2
Shetler, T.J.3
-
104
-
-
12444284584
-
Effects of human plasma-derived activated protein C on thrombolytic therapy in patients with acute myocardial infarction; comparison with unfractionated heparin
-
(Abstract)
-
SAKAMOTO T, OGAWA H, TAKAZOE K et al.: Effects of human plasma-derived activated protein C on thrombolytic therapy in patients with acute myocardial infarction; comparison with unfractionated heparin. Circulation (2002) (Suppl. II):3104 (Abstract).
-
(2002)
Circulation
, Issue.SUPPL. II
, pp. 3104
-
-
Sakamoto, T.1
Ogawa, H.2
Takazoe, K.3
-
105
-
-
0036565867
-
Antithrombotic effects of controlled inhibition of Factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model
-
SINGH I, SMITH A, VANZIELEGHEM B et al: Antithrombotic effects of controlled inhibition of Factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model. Blood (2002) 99:3235-3240.
-
(2002)
Blood
, vol.99
, pp. 3235-3240
-
-
Singh, I.1
Smith, A.2
Vanzieleghem, B.3
-
106
-
-
12444313558
-
-
IDdb3 Report (Press release, 458876)
-
CURACYTE AG. IDdb3 Report (Press release, 458876).
-
-
-
Curacyte, A.G.1
-
107
-
-
0035880995
-
Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides
-
WALL D, DOUGLAS S, FERROV, COWDEN W, PARISH C: Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides. Thromb. Res. (2001) 103:325-335.
-
(2001)
Thromb. Res.
, vol.103
, pp. 325-335
-
-
Wall, D.1
Douglas, S.2
Ferrov, A.3
Cowden, W.4
Parish, C.5
-
108
-
-
0035081904
-
Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88)
-
DEMIR M, IQBAL O, HOPPENSTEADT PA et al.: Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88). Clin. Appl. Thromb. Hemost. (2001) 7:131-140.
-
(2001)
Clin. Appl. Thromb. Hemost.
, vol.7
, pp. 131-140
-
-
Demir, M.1
Iqbal, O.2
Hoppensteadt, P.A.3
-
109
-
-
0033389110
-
Oxidative stress and atherosclerosis: Its relationship to growth factors, thrombus formation and therapeutic approaches
-
RUEF J, PETER K, NORDT TK, RUNGE MS, KUBLER W, BODE C: Oxidative stress and atherosclerosis: its relationship to growth factors, thrombus formation and therapeutic approaches. thromb. Haemost. (1999) 82(Suppl. 1):32-37.
-
(1999)
Thromb Haemost.
, vol.82
, Issue.SUPPL. 1
, pp. 32-37
-
-
Ruef, J.1
Peter, K.2
Nordt, T.K.3
Runge, M.S.4
Kubler, W.5
Bode, C.6
-
110
-
-
0036268510
-
Nitric oxide-releasing drugs: A novel class of effective and safe therapeutic agents
-
BURGAUD JL, ONGINI E, DEL SOLDATO P: Nitric oxide-releasing drugs: a novel class of effective and safe therapeutic agents. Ann. NY Acad. Sci. (2002) 962:360-371.
-
(2002)
Ann. NY Acad. Sci.
, vol.962
, pp. 360-371
-
-
Burgaud, J.L.1
Ongini, E.2
Del Soldato, P.3
-
111
-
-
12444307849
-
-
NicOx SA, on drug development pipeline (NCX-5022). IDdb3 Report (Company Comm., 453178)
-
NicOx SA, on drug development pipeline (NCX-5022). IDdb3 Report (2002) (Company Comm., 453178).
-
(2002)
-
-
-
112
-
-
0036786274
-
Aspirin resistance
-
HOWARD PA: Aspirin resistance. Ann. Pharmacother. (2002) 36:1620-1624.
-
(2002)
Ann. Pharmacother.
, vol.36
, pp. 1620-1624
-
-
Howard, P.A.1
-
113
-
-
0035998752
-
Safety, tolerability, pharmacokinetics, and time course of pharmacologic response of the active metabolite of roxifiban, XV459, a glycoprotein IIb/IIIa antagonist, following oral administration in healthy volunteers
-
PIENIASZEK HJ Jr, SY SK, EBLING W et al.: Safety, tolerability, pharmacokinetics, and time course of pharmacologic response of the active metabolite of roxifiban, XV459, a glycoprotein IIb/IIIa antagonist, following oral administration in healthy volunteers. J. Clin. Pharmacol. (2002) 42:738-753.
-
(2002)
J. Clin. Pharmacol.
, vol.42
, pp. 738-753
-
-
Pieniaszek H.J., Jr.1
Sy, S.K.2
Ebling, W.3
-
114
-
-
12444301318
-
Effects of roxifiban on platelet aggregation and major receptor expression in patients with coronary artery disease
-
(Abstract)
-
SEREBRUANY VL, MALININ AI, O'CONNOR CM, GURBEL PA: Effects of roxifiban on platelet aggregation and major receptor expression in patients with coronary artery disease. Circulation (2002) (Suppl. II):2436 (Abstract).
-
(2002)
Circulation
, Issue.SUPPL. II
, pp. 2436
-
-
Serebruany, V.L.1
Malinin, A.I.2
O'Connor, C.M.3
Gurbel, P.A.4
-
115
-
-
0035887114
-
Antiplatelet and antithrombotic activity of RWJ-53308, a novel orally active glycoprotein IIb/IIIa antagonist
-
DAMIANO BP, MITCHELL JA, GIARDINO E et al: Antiplatelet and antithrombotic activity of RWJ-53308, a novel orally active glycoprotein IIb/IIIa antagonist. Thromb. Res. (2001) 104:113-126.
-
(2001)
Thromb. Res.
, vol.104
, pp. 113-126
-
-
Damiano, B.P.1
Mitchell, J.A.2
Giardino, E.3
-
116
-
-
12444251651
-
Generation of human, activation-specific single chain antibodies directed against platelet integrin receptor GPIIb/IIIa
-
(Abstract)
-
SCHWARZ M, ROETTGEN P, LITTLE M et al.: Generation of human, activation-specific single chain antibodies directed against platelet integrin receptor GPIIb/IIIa. Circulation (2002) (Suppl. II):390 (Abstract).
-
(2002)
Circulation
, Issue.SUPPL. II
, pp. 390
-
-
Schwarz, M.1
Roettgen, P.2
Little, M.3
-
117
-
-
0033793186
-
Anti-human von Willebrand factor monoclonal antibody AjvW-2 prevents thrombus deposition and neointima formation after balloon injury in guinea pigs
-
KAGEYAMA S, YAMAMOTO H, YOSHIMOTO R: Anti-human von Willebrand factor monoclonal antibody AjvW-2 prevents thrombus deposition and neointima formation after balloon injury in guinea pigs. Arterioscler. Thromb. Vasc. Biol. (2000) 20:2303-2308.
-
(2000)
Arterioscler. Thromb. Vasc. Biol.
, vol.20
, pp. 2303-2308
-
-
Kageyama, S.1
Yamamoto, H.2
Yoshimoto, R.3
-
118
-
-
0037123856
-
Effect of a humanized monoclonal antibody to von Willebrand factor in a canine model of coronary arterial thrombosis
-
KAGEYAMA S, MATSUSHITA J, YAMAMOTO H: Effect of a humanized monoclonal antibody to von Willebrand factor in a canine model of coronary arterial thrombosis. Eur. J. Pharmacol. (2002) 443:143-149.
-
(2002)
Eur. J. Pharmacol.
, vol.443
, pp. 143-149
-
-
Kageyama, S.1
Matsushita, J.2
Yamamoto, H.3
-
119
-
-
0033710137
-
S-nitrosoderivative of a recombinant fragment of von Willebrand factor (S-nitroso-AR545C) inhibits thrombus formation in guinea pig carotid artery thrombosis model
-
GUREVITZ O, ELDAR M, SKUTELSKY E etal.: S-nitrosoderivative of a recombinant fragment of von Willebrand factor (S-nitroso-AR545C) inhibits thrombus formation in guinea pig carotid artery thrombosis model. Thromb. Haemost. (2000) 84:912-917.
-
(2000)
Thromb. Haemost.
, vol.84
, pp. 912-917
-
-
Gurevitz, O.1
Eldar, M.2
Skutelsky, E.3
-
120
-
-
0035910757
-
Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice
-
NIESWANDT B, SCHULTE V, BERGMEIER W et al.: Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J. Exp. Med. (2001) 193:459-469.
-
(2001)
J. Exp. Med.
, vol.193
, pp. 459-469
-
-
Nieswandt, B.1
Schulte, V.2
Bergmeier, W.3
-
121
-
-
0035146819
-
Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747
-
SUGIDACHI A, ASAI F, YONEDA K et al.: Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747. Br. J. Pharmacol. (2001) 132:47-54.
-
(2001)
Br. J. Pharmacol.
, vol.132
, pp. 47-54
-
-
Sugidachi, A.1
Asai, F.2
Yoneda, K.3
-
122
-
-
0037188563
-
Functional significance of adenosine 5′-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibalpha induced by conditions of high shear rate
-
GOTO S, TAMURA, N, ETO K, IKEDA Y, HANDA S: Functional significance of adenosine 5′-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibalpha induced by conditions of high shear rate. Circulation (2002) 105:2531-2536.
-
(2002)
Circulation
, vol.105
, pp. 2531-2536
-
-
Goto, S.1
Tamura, N.2
Eto, K.3
Ikeda, Y.4
Handa, S.5
-
123
-
-
0035939294
-
Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12))
-
SCARBOROUGH RM, LAIBELMAN AM, CLIZBE LA et al.: Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12)). Bioorg. Med. Chem. Lett. (2001) 11:1805-1808.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 1805-1808
-
-
Scarborough, R.M.1
Laibelman, A.M.2
Clizbe, L.A.3
-
124
-
-
0035793347
-
Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist
-
BAURAND A, RABOISSON P, FREUND M et al.: Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. Eur. J. Pharmacol. (2001) 412:213-221.
-
(2001)
Eur. J. Pharmacol.
, vol.412
, pp. 213-221
-
-
Baurand, A.1
Raboisson, P.2
Freund, M.3
-
125
-
-
13044257730
-
Design, synthesis, and biological characterization of a peptide mimetic antagonist for a tethered-ligand receptor
-
ANDRADE-GORDON P, MARYANOFF BE, DERIAN CK et al.: Design, synthesis, and biological characterization of a peptide mimetic antagonist for a tethered-ligand receptor. Proc. Natl. Acad. Sci. USA (1999) 96:12257-12262.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 12257-12262
-
-
Andrade-Gordon, P.1
Maryanoff, B.E.2
Derian, C.K.3
-
126
-
-
0036797590
-
Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation
-
COVIC L, MISRA M, BADAR J, SINGH C, KULIOPULOS A: Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation. Nat. Med. (2002) 8:1161-1165.
-
(2002)
Nat. Med.
, vol.8
, pp. 1161-1165
-
-
Covic, L.1
Misra, M.2
Badar, J.3
Singh, C.4
Kuliopulos, A.5
-
127
-
-
0036194010
-
Thrombostatin, a bradykinin metabolite, reduces platelet activation in a model of arterial wall injury
-
PRIETO AR, MA H, HUANG R et al.: Thrombostatin, a bradykinin metabolite, reduces platelet activation in a model of arterial wall injury. Cardiovasc. Res. (2002) 53:984-992.
-
(2002)
Cardiovasc. Res.
, vol.53
, pp. 984-992
-
-
Prieto, A.R.1
Ma, H.2
Huang, R.3
-
128
-
-
0034716972
-
Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin
-
MOMI S, EMERSON M, PAUL W et al.: Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin. Eur. J. Pharmacol. (2000) 397:177-185.
-
(2000)
Eur. J. Pharmacol.
, vol.397
, pp. 177-185
-
-
Momi, S.1
Emerson, M.2
Paul, W.3
-
129
-
-
0037058876
-
NCX-4016(NO-Aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo
-
FIORUCCI S, MENCARELLI A, MENEGUZZI A et al.: NCX-4016(NO-Aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo. Circulation (2002) 106:3120-3125.
-
(2002)
Circulation
, vol.106
, pp. 3120-3125
-
-
Fiorucci, S.1
Mencarelli, A.2
Meneguzzi, A.3
-
130
-
-
0030747376
-
Antithrombotic and vasorelaxant properties of a novel synthetic RGD peptide containing nitric oxide
-
GUREVICH VS, LOMINADZE DG, ADEAGBO AS et al: Antithrombotic and vasorelaxant properties of a novel synthetic RGD peptide containing nitric oxide. Pharmacology (1997) 55:1-9.
-
(1997)
Pharmacology
, vol.55
, pp. 1-9
-
-
Gurevich, V.S.1
Lominadze, D.G.2
Adeagbo, A.S.3
-
131
-
-
0036165065
-
Novel approaches to the treatment of thrombosis
-
GRESELE P, AGNELLI G: Novel approaches to the treatment of thrombosis. Trends Pharmacol. Sci. (2002) 23:25-32.
-
(2002)
Trends Pharmacol. Sci.
, vol.23
, pp. 25-32
-
-
Gresele, P.1
Agnelli, G.2
-
133
-
-
0035128439
-
New anticoagulant drugs
-
WEITZ JI, HIRSH J: New anticoagulant drugs. Chest (2001) 119(Suppl.):95S-107S.
-
(2001)
Chest
, vol.119
, Issue.SUPPL.
-
-
Weitz, J.I.1
Hirsh, J.2
-
134
-
-
0030879804
-
Platelet activation and inhibition in unstable coronary syndromes
-
PATRONO C, RENDA G: Platelet activation and inhibition in unstable coronary syndromes. Am. J. Cardiol. (1997) 80:E17-E20.
-
(1997)
Am. J. Cardiol.
, vol.80
-
-
Patrono, C.1
Renda, G.2
-
135
-
-
0037072090
-
Aspirin and coumadin after acute coronary syndromes (the ASPECT-2 study): A randomised controlled trial
-
VAN ES RF, JONKER JJ, VERHEUGT FW, DECKERS JW, GROBBEE DE: Aspirin and coumadin after acute coronary syndromes (the ASPECT-2 study): a randomised controlled trial. Lancet (2002) 360:109-113.
-
(2002)
Lancet
, vol.360
, pp. 109-113
-
-
Van Es, R.F.1
Jonker, J.J.2
Verheugt, F.W.3
Deckers, J.W.4
Grobbee, D.E.5
-
136
-
-
0033767132
-
Aggrenox: A fixed-dose combination of aspirin and dipyridamole
-
LENZ TL, HILLEMAN DE: Aggrenox: a fixed-dose combination of aspirin and dipyridamole. Ann. Pharmacother. (2000) 34:1283-1290.
-
(2000)
Ann. Pharmacother.
, vol.34
, pp. 1283-1290
-
-
Lenz, T.L.1
Hilleman, D.E.2
|