Congenital Hypothyroidism with Goiter in Toy Fox Terriers

Journal of Veterinary Internal Medicine

Volumn 17, Issue 1, 2003, Pages 50-57

  Fyfe, John C ^a   Kampschmidt, Kit ^b   Dang, Van ^a   Poteet, Brian A ^c   He, Qianchuan ^a   Lowrie, Charles ^a   Graham, Peter A ^a   Fetro, Virginia M ^d  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Brittmoore Animal Hospital   (United States)

^c GULF COAST VETERINARY SPECIALISTS   (United States)

^d NONE

Author keywords

Carrier test; Dyshormonogenesis; Mutation; Organification defect; Thyroid peroxidase

Indexed keywords

DODECYL SULFATE SODIUM; RADIOACTIVE IODINE; RECOMBINANT THYROTROPIN; THYROGLOBULIN; THYROID HORMONE; THYROID PEROXIDASE; IODIDE PEROXIDASE;

ANIMAL TISSUE; AUTOSOMAL RECESSIVE INHERITANCE; BODY GROWTH; CELL HYPERPLASIA; CHEMICAL ANALYSIS; COLUMNAR EPITHELIUM; CONFERENCE PAPER; CONGENITAL HYPOTHYROIDISM; CONTROLLED STUDY; DISEASE CARRIER; DOG; ENZYME DEFICIENCY; FEMALE; GENETIC PREDISPOSITION; GOITER; HISTOLOGY; HORMONE SUBSTITUTION; IODINE DEFICIENCY; ISOTOPE TRACING; MALE; NONHUMAN; NONSENSE MUTATION; TERATOMA; THYROID HORMONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; ANIMAL; ANIMAL DISEASE; ARTICLE; DOG DISEASE; GENETICS; HETEROZYGOTE; HYPOTHYROIDISM; NUCLEOTIDE SEQUENCE; PEDIGREE; STOP CODON;

ANIMALIA; CANIDAE; CANIS FAMILIARIS;

ANIMALS; CODON, NONSENSE; CONGENITAL HYPOTHYROIDISM; DNA MUTATIONAL ANALYSIS; DOG DISEASES; DOGS; FEMALE; GOITER; HETEROZYGOTE; HYPOTHYROIDISM; IODIDE PEROXIDASE; MALE; PEDIGREE;

EID: 0037797118     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1892/0891-6640(2003)017<0050:CHWGIT>2.3.CO;2     Document Type: Conference Paper

References (32)

1. Braverman LE, Utiger RD. Introduction to hypothyroidism. In: Braverman LE, Utiger RD, eds. The Thyroid, a Fundamental and Clinical Text, 7th ed. Philadelphia, PA: Lippincott-Raven Co; 1996:736-737.
2. Refetoff S, Dumont J, Vassart G. Thyroid disorders. In: Scriver CR, Beaudet AL, Sly WS, et al, eds. The Metabolic & Molecular Bases of Inherited Disease, 8th ed. New York, NY: McGraw Hill, Inc; 2001:4029-4075.
3. Moreno JC, Bikker H, Kempers MJE, et al. Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. N Engl J Med 2002;347:95-102.
4. Brouwers J. Goitre et hérédité chez le chien. Ann Med Vet 1950; 94:173-174.
5. Chastain CB, McNeel SV, Graham CL, Pezzanite SC. Congenital hypothyroidism in a dog due to an iodide organification defect. Am J Vet Res 1983;44:1257-1265.
6. Arnold U, Opitz M, Grossier I, et al. Goitrous hypothyroidism and dwarfism in a kitten. J Am Anim Hosp Assoc 1984;20:753-758.
7. Medleau L, Eigenmann JE, Saunders HM, Goldschmidt MH. Congenital hypothyroidism in a dog. J Am Anim Hosp Assoc 1985; 21:341-344.
8. Robinson WF, Shaw SE, Stanley B, et al. Congenital hypothyroidism in Scottish Deerhound puppies. Aust Vet J 1988;65:386-389.
9. Greco DS, Feldman EC, Petterson ME, et al. Congenital hypothyroid dwarfism in a family of Giant Schnauzers. J Vet Intern Med 1991;5:57-65.
10. Saunders HM, Jezyk PF. The radiographic appearance of canine congenital hypothyroidism; skeletal changes with delayed treatment. Vet Radiol 1991;32:171-177.
11. Mooney CT, Anderson TJ. Congenital hypothyroidism in a Boxer dog. J Small Anim Pract 1993;34:31-35.
12. Lieb AS, Grootes AM, Tyler JW, et al. Tetraparesis due to vertebral physeal fracture in an adult dog with congenital hypothyroidism. J Small Anim Pract 1997;38:364-367.
13. Casal ML, Zerbe CA, Jezyk PF, et al. Thyroid profiles in healthy puppies from birth to 12 weeks of age. J Vet Intern Med 1994;8:158.
14. Nachreiner RF, Refsal KR, Ravis WR, et al. Pharmacokinetics of L-thyroxine after its oral administration in dogs. Am J Vet Res 1993; 54:2091-2098.
15. Panciera DL, MacEwen EG, Atkins CE, et al. Thyroid function tests in euthyroid dogs treated with L-thyroxine. Am J Vet Res 1989; 51:22-26.
16. Dixon RM, Mooney CT. Evaluation of serum free thyroxine and thyrotropin concentrations in the diagnosis of canine hypothyroidism. J Small Anim Pract 1999;40:72-78.
17. Peterson ME, Melian C, Nichols R. Measurement of serum total thyroxine, triodothyronine, free thyroxine, and thyrotropin concentrations for diagnosis of hypothyroidism in dogs. J Am Vet Med Assoc 1997;211:1396-1402.
18. Taurog A, Dorris ML, Yokoyama N, Slaughter C. Purification and characterization of a large, tryptic fragment of human thyroid peroxidase with high catalytic activity. Arch Biochem Biophys 1990; 278:333-341.
19. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
20. Nakashima T, Taurog A. Improved assay procedures for thyroid peroxidase; application to normal and adenomatous human thyroid tissue. Clin Chim Acta 1978;83:129-140.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-275.
22. Lefort A, Lecocq R, Libert F, et al. Cloning and sequencing of a calcium-binding protein regulated by cyclic AMP in the thyroid. EMBO J 1989;8:111-116.
23. - symporter mRNAs in dog thyroid. Mol Cell Endocrinol 1997;131:195-203.
24. Henthorn PS, Somberg RL, Fimiani VM, et al. IL-2R gamma gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease. Genomics 1994;23:69-74.
25. Xu D, Kozyraki R, Newman TC, Fyfe JC. Genetic evidence of an accessory protein activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption. Blood 1999;94:3604-3606.
26. Kawasaki ES. Sample preparation from blood, cells, and other fluids. In Innis MA, Gelfand DH, Sninsky JJ, White TJ, eds. PCR Protocols: Guide to Methods and Applications. San Diego, CA: Academic Press; 1990:146-152.
27. Seed RW, Goldberg IH. Iodination in relation to thyroglobulin maturation and subunit aggregation. Science 1965;149:1380-1382.
28. Edelhoch H, Robbins J. Thyroglobulin: Chemistry and biosynthesis. In: Ingbar SH, Braverman LE, eds. Werner's The Thyroid: A Fundamental and Clinical Text, 5th ed. Philadelphia, PA: JP Lippincott Co; 1986:98-115.
29. Abramowicz MJ, Targovnik HM, Varela V, et al. Identification of a mutation in the coding sequence of the human thyroid peroxidase gene causing congenital goiter. J Clin Invest 1992;90:1200-1204.
30. Fyfe JC. Molecular diagnosis of inherited neuromuscular disease. In: Shelton GD, ed. Veterinary Clinics of North America: Small Animal Practice, Neuromuscular Diseases. Philadelphia, PA: WB Saunders; 2002;32:287-300.
31. Spence MA, Hodge SE. Segregation analysis. In: Rimoin DL, Connor JM, Pyeritz RE, eds. Emery & Rimoin's Principles and Practice of Medical Genetics, 3rd ed. New York, NY: Churchill Livingston; 1996:103-109.
32. Fyfe JC. Congenital hypothyroidism with goiter in toy fox terriers. Bloodlines 2002;84:32-33.