Effect of paeonol on L-type calcium channel in rat ventricular myocytes

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 25, Issue 4, 2003, Pages 281-285

  Zhang, G Q ^a   Hao, X M ^a   Zhou, P A ^a   Wu, C H ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

L type calcium current; Paeonol; Patch clamp; Ventricular myocytes

Indexed keywords

4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATE; BOVINE SERUM ALBUMIN; CALCIUM CHANNEL L TYPE; CALCIUM ION; CESIUM CHLORIDE; EGTAZIC ACID; PEONOL; TETRODOTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CARDIOVASCULAR SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC POTENTIAL; HEART MUSCLE INJURY; HEART VENTRICLE WALL; IC 50; MEMBRANE CURRENT; MUSCLE CELL; NONHUMAN; PATCH CLAMP; RAT; STEADY STATE;

EID: 0037787950     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2003.25.4.769676     Document Type: Article

References (16)

1. Papandreou, V., Magiatis, P., Chinou, I., Kalpoutzakis, E., Skaltsounis, A.L., Tsarbopoulos, A. Volatiles with antimicrobial activity from the roots of Greek Paeonia taxa. J Ethnopharmacol 2002, 81:101-4.
2. Li, F.C., Zhou, X.L., Mao, H.L. A study of paeonol injection on immune functions in rats. Zhongguo Zhong Xi Yi Jie He Za Zhi 1994, 14: 37-8.
3. Sun, F.Z., Cai, M., Lou, F.C. Analgesic effect and gastro-intestinal motility inhibitory action of 3-hydroxy-4-methoxy-acetopheuone from Cynanchum paniculatum (Bange) Kitagawa. Zhongguo Zhong Yao Za Zhi 1993, 18: 362-3.
4. Shi, L., Fan, P.S., Fang, J.X., Han, Z.X. Inhibitory effects of paeonol on experimental atherosclerosis and platetet aggregation of rabbit. Acta Pharmacologica Sinica 1988, 9: 555-8.
5. Zhang, W.G., Zhang, Z.S. Anti-ischemia reperfusion damage and anti-lipid peroxidation effects of paeonol in rat heart. Acta Pharmaceutica Sinica 1994, 29: 145-8.
6. Tang, J.R., Shi, L. Effect of paeonol on calcium uptake in the cultured neonatal rat myocardical cells. Chin J Pharmacol Toxicol 1991, 5: 108-10.
7. Tang, J.R., Shi, L. The protective effects of paeonol on cultured neonatal rat heart cells during calcium paradox. Zhongguo Zhong Yao Za Zhi 1991, 16: 557-60.
8. Tang, J.R., Shi, L. The inhibitory effects of sodium paeonol sulfate on calcium influx in the cultured neonatal rat heart cells during calcium paradox. Acta Pharmaceutica Sinica 1991, 26: 161-5.
9. 2+ currents in neuroblastoma x glioma hybrid cells by paeonol. Sheng Li Xue Bao 1994, 46: 575-80.
10. 2+ currents and human atrial fibrillation. Circ Res 1999, 85: 428-36.
11. Mukherjee, R., Spinale, EG. L-type calcium channel abundance and function with cardiac hypertrophy and failure: A review. J Mol Cell Cardiol 1998, 30: 1899-916.
12. 2+ currents in compensated hypertrophy and heart failure. Cardiovasc Res 1998, 37: 300-11.
13. Aggarwal, R., Boyden, P.A. Diminished calcium and barium currents in myocytes surviving in the epicardial border zone of the 5-day infarcted canine heart. Circ Res 1995, 77: 1180-91.
14. Tytgat, J. How to isolate cardiac myocytes. Cardiovasc Res 1994, 28: 280-3.
15. Zhang, G.Q., Yu, Z.L., Zhao, H.C. Inhibition of paeonol on arrhythmias induced by ischemia-reperfusion in rats. J Chin Pharm Univ 1997, 28: 225-7.
16. Chen, J.B., Tang, Q.H., Huang, C.X. Effects of paeonal on automaticity and delayed after depolarization of gainea pig papillary muscles. Chin J Appl Physiol 1999, 15: 332-4.