Urinary PAH metabolites influenced by genetic polymorphisms of GSTM1 in male hospital incinerator workers

Journal of Occupational Health

Volumn 45, Issue 3, 2003, Pages 168-171

  Lee, Kyoung Ho ^a,b   Cho, Soo Hun ^a,b   Hong, Yun Chul ^c   Lee, Kwan Hee ^c   Kwan, Ho Jang ^c   Choi, Inmi ^b   Kang, Daehee ^a,b  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Institute of Environmental Medicine ^*

Author keywords

1 hydroxypyrene glucuronide; Genetic polymorphism; Glutathione S transferases; Hospital incinerator workers; Polycyclic aromatic hydrocarbon

Indexed keywords

1 HYDROXYPYRENE GLUCURONIDE; GLUCURONIDE; GLUTATHIONE TRANSFERASE M1; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ADULT; ANTIBODY AFFINITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FLUORESCENCE SPECTROSCOPY; GENETIC POLYMORPHISM; GENOTYPE; HOSPITAL PERSONNEL; HOSPITAL WASTE; HUMAN; INCINERATION; MALE; METABOLISM; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; POLYMERASE CHAIN REACTION; PROTECTIVE EQUIPMENT; PYROLYSIS; QUESTIONNAIRE; RANK SUM TEST; URINARY EXCRETION; URINE LEVEL;

ADULT; DNA ADDUCTS; GENOTYPE; GLUCURONATES; GLUTATHIONE TRANSFERASE; HOSPITALS; HUMANS; INCINERATION; INHALATION EXPOSURE; KOREA; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; POLYCYCLIC HYDROCARBONS, AROMATIC; POLYMORPHISM, GENETIC; PROTECTIVE CLOTHING; PYRENES; QUESTIONNAIRES; STATISTICS, NONPARAMETRIC;

EID: 0037787808     PISSN: 13419145     EISSN: None     Source Type: Journal    
DOI: 10.1539/joh.45.168     Document Type: Article

References (23)

1. E Weir: Hospitals and the environment. Canadian Medical Association 166, 354 (2002)
2. CC Austin, D Wang, DJ Ecobichon and D Dussault: Charactrization of volatile organic compounds in smoke at experimental fires. J Toxicol Environ Health 63, 191-206 (2001)
3. FJ Jongeneelen, RB Arizon and MPT Henderson: Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in urine. J Chromatogr 413, 227-232 (1987)
4. S Zhong, AH Wyllie, D Barnes, CR Wolf and NK Spurr: Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis 14, 1821-1824 (1993)
5. PT Strickland, D Kang, ED Bowman, A Fitzwilliam, TE Downing, N Rothman, JD Groopman and A Weston: Identification of 1-hydroxypyrene glucuronide as a major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatograpy mass spectrometry. Carcinogenesis 15, 483-487 (1994)
6. R Singh, M Tucek, K Maxa, L Tenglerova and EH Weyand: A rapid and simple method for the analysis of 1-hydroxypyrene glucuronide: a potential biomarker for polycyclic aromatic hydrocarbon exposure. Carcinogenesis 16, 2909-2915 (1995)
7. M Lipniak-Gawlik: Effect of polycyclic aromatic hydrocarbons on the elimination kinetics of pyrene and the urinary excretion profile of 1-hydroxypyrene in the rat. J Toxicol Environ Health Part 55, 503-516 (1998)
8. PT Strickland and D Kang: Urinary 1-hydroxypyrene and other PAH metabolites as biomarkers of exposure to environmental PAH in air particulate matter. Toxicology Letters 108, 191-199 (1999)
9. E Clonfero, M Granella, M Marchioro, E Leopardi Barra, B Nardini, G Ferri and V Foá: Urinary excretion of mutagens in coke oven workers. Carcinogenesis 16, 547-554 (1995)
10. B Coles and B Ketterer: The role of glutathione and glutathione transferases in chemical carcinogenesis. CRC Crit Rev Biochem Mol Biol 25, 47-70 (1990)
11. B Ketterer: protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mutatation Research 202, 343-361 (1988)
12. S Pemble, KR Schroeder, SR Spencer, DJ Meyer, E Hallier, HM Bolt, B Ketterer and JB Taylor: Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J 300, 271-276 (1994)
13. DJ Meyer, B Coles, SE Pemble, KS Gilmore, GM Fraser and B Ketterer: Theta, a new class of glutathione transferases purified from rat and man. Biochem J 274, 409-414 (1991)
14. YC Hong, JH Leem, HS Park, KH Lee, SJ Lee, CK Lee and Kang D: Variations in urinary 1-hydroxypyrene glucuronide in relation to smoking and the modification effects of GSTM1 and GSTT1. Toxicology Letters 108, 217-223 (1999)
15. HS Park, EH Ha, KH Lee and YC Hong: Benzo[a]pyrene-induced DNA-protein crosslinks in cultured human lymphocytes and the role of the GSTM1 and GSTT1 genotypes. J Korean Med Sci 17, 316-321 (2002)
16. SK Park, KY Yoo, SJ Lee, SU Kim, SH Ahn, DY Noh, KJ Choe, PT Strickland, A Hirvonen and Kang D: Alcohol consumption, glutathione S-transferase M1 and T1 genetic polymorphisms and breast cancer risk. Pharmacogenetics 10, 301-309 (2000)
17. H Chen, DP Sandler, JA Talyor, DL Shore and E Liu: Bloomfield CD, Bell DA. Increased risk for myelodysplastic syndromes among those with glutathione S-transferase theta 1 (GSTT1) gene defect. Lancet 347, 195-197 (1996)
18. J Lee, D Kang, KH Lee, M Ichiba, J Zhang, K Tomokuni, ES Hwang, CG Park, M Ha, S Kim, SB Han, JW Choi, E Lee, JY Jang, PT Strickland, A Hirvonen and SH Cho: Influence of GSTM1 genotype on association between aromatic DNA adducts and urinary PAH metabolites in incineration workers. Mutation Research 514, 213-221 (2002)
19. FJ Jongeneelen, RB Anzion, PT Scheepers, RP Bos, PT Henderson, EH Nijenhuis, SJ Veenstra, RM Brouns and A Winkes: 1-Hydroxypyrene in urine as a biological indicator of exposure to polycyclic aromatic hydrocarbons in several work environments. Ann Occup Hyg 32, 35-43 (1988)
20. E Boyland and P Sims: Metabolism of polycyclic compounds: 23. The metabolism of pyrene in rats and rabbits. Biochemical J 90, 391-398 (1964)
21. C Vaury, R Laine, P Noguiez, P de Coppet, C Jaulin, F Praz, D Pompon and M Amor-Gueret: Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription. Cancer Research 55, 5520-5523 (1995)
22. G Gabbani, SM Hou, B Nardini, M Marchioro, B Lambert and E Clonfero: GSTM1 and NAT2 genotypes and urinary mutagens in coke oven workers. Carcinogenesis 17, 1677-1681 (1996)
23. F Merlo, A Andreassen, A Weston, CF Pan, A Haugen, F Valreio, G Reggiardo, V Fontana, S Garte, R Puntoni and A Abbondandolo: Urinary excretion of 1-hydroxypyrene as a marker for exposure to urban air levels of polycyclic aromatic hydrocarbons. Cancer Epidemiol Biomarkers & Prev 7, 147-155 (1998)