Conserved cholecystokinin receptor transmembrane domain IV amino acids confer peptide affinity

Journal of Molecular Neuroscience

Volumn 20, Issue 2, 2003, Pages 115-123

  Ren, Yong ^a   Bläker, Michael ^a,b   Seshadri, Lakshmi ^a   McBride, Edward W ^a   Beinborn, Martin ^a   Kopin, Alan S ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Affinity determinant; Cholecystokinin; Cholecystokinin receptor; G protein coupled receptor; Peptide affinity; Transmembrane domain

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; ALANINE; AMINO ACID; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; CHOLECYSTOKININ RECEPTOR; G PROTEIN COUPLED RECEPTOR; INOSITOL PHOSPHATE; L 364714; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; LIGAND BINDING; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL MEMBRANE; COS CELLS; EUKARYOTIC CELLS; EVOLUTION, MOLECULAR; HUMANS; MUTATION; PROTEIN STRUCTURE, TERTIARY; RADIOLIGAND ASSAY; RECEPTOR, CHOLECYSTOKININ A; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ; SINCALIDE; TRITIUM;

ANIMALIA;

EID: 0037783327     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:20:2:115     Document Type: Article

References (32)

1. Anders J., Bluggel M., Meyer H. E., Kuhne R., ter Laak A. M., Kojro E., and Fahrenholz F. (1999) Direct identification of the agonist binding site in the human brain cholecystokinin B receptor. Biochemistry 38, 6043-6055.
2. Baldwin J. M. (1993) The probable arrangement of the helices in G protein-coupled receptors. EMBO J. 12, 1693-1703.
3. Baldwin J. M., Schertler G. F., and Unger V. M. (1997) An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors. J. Mol. Biol. 272, 144-164.
4. Beinborn M., Lee Y. M., McBride E. W., Quinn S. M., and Kopin A. S. (1993) A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists. Nature 362, 348-350.
5. Bläker M., Ren Y., Gordon M. C., Hsu J. E., Beinborn M., and Kopin A. S. (1998) Mutations within the cholecystokinin-B/gastrin receptor ligand "pocket" interconvert the functions of nonpeptide agonists and antagonists. Mol. Pharmacol. 54, 857-863.
6. Bläker M., Ren Y., Seshadri L., McBride E. W., Beinborn M., and Kopin A. S. (2000) CCK-B/gastrin receptor transmembrane domain mutations selectively alter synthetic agonist efficacy without affecting the activity of endogenous peptides. Mol. Pharmacol. 58, 399-406.
7. Blandizzi C., Song I., and Yamada T. (1994) Molecular cloning and structural analysis of the rabbit gastrin/CCKB receptor gene. Biochem. Biophys. Res. Commun. 202, 947-953.
8. Corp E. S., Curcio M., Gibbs J., and Smith G. P. (1997) The effect of centrally administered CCK-receptor antagonists on food intake in rats. Physiol. Behav. 61, 823-827.
9. Crawley J. N. and Corwin R. L. (1994) Biological actions of cholecystokinin. Peptides 15, 731-755.
10. de Weerth A., Pisegna J. R., Huppi K., and Wank S. A. (1993) Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor. Biochem. Biophys. Res. Commun. 194, 811-818.
11. Dufresne M., Escrieut C., Clerc P., Le Huerou-Luron I., Prats H., Bertrand V., et al. (1996) Molecular cloning, developmental expression and pharmacological characterization of the CCKB/gastrin receptor in the calf pancreas. Eur. J. Pharmacol. 297, 165-179.
12. Gether U. (2000) Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr. Rev. 21, 90-113.
13. Gibbs J., Young R. C., and Smith G. P. (1973) Cholecystokinin decreases food intake in rats. J. Comp. Physiol. Psychol. 84, 488-495.
14. Gigoux V., Escrieut C., Fehrentz J. A., Poirot S., Maigret B., Moroder L., et al. (1999) Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin. J. Biol. Chem. 274, 20457-20464.
15. Giragossian C. and Mierke D. F. (2001) Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor. Biochemistry 40, 3804-3809.
16. Gouldson P., Legoux P., Carillon C., Delpech B., Le Fur G., Ferrara P., and Shire D. (2000) The agonist SR 146131 and the antagonist SR 27897 occupy different sites on the human CCK(1) receptor. Eur. J. Pharmacol. 400, 185-194.
17. Ji T. H., Grossmann M., and Ji I. (1998) G protein-coupled receptors. I. Diversity of receptor-ligand interactions. J. Biol. Chem. 273, 17299-17302.
18. Kopin A. S., Lee Y. M., McBride E. W., Miller L. J., Lu M., Lin H. Y., et al. (1992) Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc. Natl. Acad. Sci. USA 89, 3605-3609.
19. Kopin A. S., Mathes W. F., McBride E. W., Nguyen M., Al-Haider W., Schmitz F., et al. (1999) The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J. Clin. Invest. 103, 383-391.
20. Kopin A. S., McBride E. W., Quinn S. M., Kolakowski L. F. Jr., and Beinborn M. (1995) The role of the cholecystokinin-B/gastrin receptor transmembrane domains in determining affinity for subtype-selective ligands. J. Biol. Chem. 270, 5019-5023.
21. Lee Y. M., Beinborn M., McBride E. W., Lu M., Kolakowski L. F. Jr., and Kopin A. S. (1993) The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. J. Biol. Chem. 268, 8164-8169.
22. Nakata H., Ito M., Taniguchi T., Naribayashi Y., Arima N., Nakamura A., et al. (1992) Cloning and characterization of gastrin receptor from ECL carcinoid tumor of Mastomys natalensis. Biochem. Biophys. Res. Commun. 187, 1151-1157.
23. Noble F., Wank S. A., Crawley J. N., Bradwejn J., Seroogy K. B., Hamon M., and Roques B. P. (1999) International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol. Rev. 51, 745-781.
24. Palczewski K., Kumasaka T., Hori T., Behnke C. A., Motoshima H., Fox B. A., et al. (2000) Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289, 739-745.
25. Reuben M., Rising L., Prinz C., Hersey S., and Sachs G. (1994) Cloning and expression of the rabbit gastric CCK-A receptor. Biochim. Biophys. Acta 1219, 321-327.
26. Saito A., Sankaran H., Goldfine I. D., and Williams J. A. (1980) Cholecystokinin receptors in the brain: characterization and distribution. Science 208, 1155-1156.
27. Schmitz F., Pratt D. S., Wu M. J., Kolakowski L. Jr., Beinborn M., and Kopin A. S. (1996) Identification of cholecystokinin-B/gastrin receptor domains that confer high gastrin affinity: utilization of a novel Xenopus laevis cholecystokinin receptor. Mol. Pharmacol. 50, 436-441.
28. Silvente-Poirot S., Escrieut C., and Wank S. A. (1998) Role of the extracellular domains of the cholecystokinin receptor in agonist binding. Mol. Pharmacol. 54, 364-371.
29. Takata Y., Takiguchi S., Kataoka K., Funakoshi A., Miyasaka K., and Kono A. (1997) Mouse cholecystokinin type-A receptor gene and its structural analysis. Gene 187, 267-271.
30. Ulrich C. D., Ferber I., Holicky E., Hadac E., Buell G., and Miller L. J. (1993) Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor. Biochem. Biophys. Res. Commun. 193, 204-211.
31. Unger V. M., Hargrave P. A., Baldwin J. M., and Schertler G. F. (1997) Arrangement of rhodopsin transmembrane alpha-helices. Nature 389, 203-206.
32. Wank S. A., Harkins R., Jensen R. T., Shapira H., de Weerth A., and Slattery T. (1992) Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas. Proc. Natl. Acad. Sci. USA 89, 3125-3129.